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Antiviral

Valacyclovir for Gum Disease

Phase < 1
Recruiting
Led By Mike Sabeti, DDS
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients must be systemically healthy, Class I dental category.
Involved teeth must have periodontal disease detectible by periodontal examination.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial will test if a herpesvirus drug can help stop the progression of severe gum disease in adults.

Who is the study for?
This trial is for adults with severe gum disease, evidenced by deep periodontal pockets and specific x-ray findings. Participants must be in good overall health and not smoke heavily. Pregnant or nursing women, those allergic to valacyclovir, under 18s, individuals with kidney issues or immune-altering conditions/medications are excluded.Check my eligibility
What is being tested?
The study tests if Valacyclovir (Valtrex), an anti-herpesvirus medication, can halt the progression of severe gum disease. It's a double-blind trial where patients are randomly assigned to either the Valacyclovir group or a placebo control group.See study design
What are the potential side effects?
Potential side effects of Valacyclovir may include headache, nausea, stomach pain, vomiting and dizziness. Rarely it might cause more serious reactions like changes in mental state or kidney problems.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am generally healthy and have no major dental issues.
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My teeth have gum disease confirmed by a dental exam.
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I have deep gum disease with significant bone loss.
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I am generally healthy and have no major dental issues.
Select...
My teeth have gum disease confirmed by a dental exam.
Select...
I have deep gum disease with significant bone loss.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinical attachment level
Periodontal pocket depth
gingival bleeding on probing

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: valacyclovir groupExperimental Treatment1 Intervention
Patients (N=20) in the valacyclovir group will be received, at baseline, periodontal scaling + valacyclovir (500 mg, 3 times a day for 3 days) ("Valacyclovir" group).
Group II: Control groupActive Control1 Intervention
Patients (N=20) in the control group will receive, at baseline, periodontal scaling + placebo medication, three times a day for 3 days ("Control" group).

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,505 Previous Clinical Trials
15,237,515 Total Patients Enrolled
Mike Sabeti, DDSPrincipal InvestigatorUniversity of California, San Francisco
2 Previous Clinical Trials
250 Total Patients Enrolled

Media Library

Valacyclovir (Antiviral) Clinical Trial Eligibility Overview. Trial Name: NCT05712343 — Phase < 1
Gum Disease Research Study Groups: valacyclovir group, Control group
Gum Disease Clinical Trial 2023: Valacyclovir Highlights & Side Effects. Trial Name: NCT05712343 — Phase < 1
Valacyclovir (Antiviral) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05712343 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who can qualify to be a participant in this research study?

"To qualify for this study, prospective participants must have periodontal disease and be aged 18 to 80. A total of 40 patients are being recruited."

Answered by AI

Is it a requirement for participants to be under 40 years old in order to join this research?

"According to the study's parameters, participants eligible for enrollment must be aged 18-80. Additionally, there are 3 clinical trials available for minors and 67 separate studies that are open to individuals above 65 years of age."

Answered by AI

Are there still opportunities to enroll in this clinical experiment?

"As the information on clinicaltrials.gov reveals, this medical trial is no longer actively recruiting participants. The study was first published on February 25th 2023 and has not been updated since January of that year; however, 84 other trials are currently enrolling patients at present."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis
2023. "The Efficacy of Systemic Valacyclovir (Valtrex) on Periodontitis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05712343.
~21 spots leftby Apr 2025
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