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[18F]FLT-PET/CT for Pediatric Solid Tumors

Q: Are there any age limitations for enrolment in this clinical trial?

The protocol of this clinical trial states that the minimum age requirement for participants is 8 years old, while 25 is the upper limit.

Q: How many participants are participating in this clinical research?

Yes, according to clinicaltrials.gov, the trial still seeks participants as of this time. It was first posted on August 13th 2019 and updated most recently on August 2nd 2022. The study requires 20 individuals from a single medical site for enrollment.

Q: Is this trial accepting new participants at the present time?

Per the information on clinicaltrials.gov, this medical trial is actively in search of patients to enter into its research program. The investigation's inception was logged on August 13th 2019 and an edit was made as recently as August 2nd 2022.

Q: Who meets the qualifications to participate in this scientific research?

This trial is enrolling 20 patients aged between 8 and 25 who have malignant solid tumours that need to be treated with the standard of care chemotherapy for a certain number of cycles. <a href="https://www.withpower.com/clinical-trials/all">All</a> types of tumors, including those found in the central nervous system are welcome and both newly diagnosed cases and relapsed patient may apply. Participants must have a performance status greater than 50%, provide proof that they do not engage in childbearing activities if applicable, understand written informed consent/assent documents, as well as demonstrate their ability to remain motionless during imaging without needing sedation for 20-30 minutes.

Phase < 1

Waitlist Available

Led By Laura Klesse, MD, PhD

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 24 months following treatment

Awards & highlights

Study Summary

This trial is testing a new way to image cancer using PET/CT before starting chemotherapy. Standard care treatment and follow up is 24 months.

Eligible Conditions

Solid Tumors

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 24 months following treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 24 months following treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 months following treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Correlation between change in [18F]FLT PET/CT and progression free and overall survival

Trial Design

1Treatment groups

Experimental Treatment

Group I: [18F]FLT-PET/CT ArmExperimental Treatment1 Intervention

The experimental [18F]FLT-PET/CT will be completed before initiation of chemotherapy and prior to the third cycle (or month) of chemotherapy. Laboratory analysis and correlative radiology, as directed per clinical care based on the primary diagnosis, are required within 30 days of the baseline [18F]FLT PET/CT. Follow-up will comprise 24 months of standard practice treatment and follow up.

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Who is running the clinical trial?

University of Texas Southwestern Medical CenterLead Sponsor

1,047 Previous Clinical Trials

1,053,799 Total Patients Enrolled

Laura KlesseLead Sponsor

Laura Klesse, MD, PhDPrincipal Investigator - University of Texas Southwestern Medical Center

Children's Medical Center of Dallas, UT Southwestern Medical Center-Zale Lipshy Campus

University Of Texas Southwestern Medical Ctr At Dallas (Medical School)

University Tx Southwestern Medical Sch (Residency)

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any age limitations for enrolment in this clinical trial?

"The protocol of this clinical trial states that the minimum age requirement for participants is 8 years old, while 25 is the upper limit."

Answered by AI

How many participants are participating in this clinical research?

"Yes, according to clinicaltrials.gov, the trial still seeks participants as of this time. It was first posted on August 13th 2019 and updated most recently on August 2nd 2022. The study requires 20 individuals from a single medical site for enrollment."

Answered by AI

Is this trial accepting new participants at the present time?

"Per the information on clinicaltrials.gov, this medical trial is actively in search of patients to enter into its research program. The investigation's inception was logged on August 13th 2019 and an edit was made as recently as August 2nd 2022."

Answered by AI

Who meets the qualifications to participate in this scientific research?

"This trial is enrolling 20 patients aged between 8 and 25 who have malignant solid tumours that need to be treated with the standard of care chemotherapy for a certain number of cycles. All types of tumors, including those found in the central nervous system are welcome and both newly diagnosed cases and relapsed patient may apply. Participants must have a performance status greater than 50%, provide proof that they do not engage in childbearing activities if applicable, understand written informed consent/assent documents, as well as demonstrate their ability to remain motionless during imaging without needing sedation for 20-30 minutes."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Evaluation of [18F]FLT PET/CT as an Early Predictor of Outcome in Pediatric Solid Tumors

Laura Klesse 2019. "Evaluation of [18F]FLT PET/CT as an Early Predictor of Outcome in Pediatric Solid Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03905538.