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Opioid Analgesic

Ibuprofen, acetaminophen, oxycodone for Cesarean Section Complications (ERAS Trial)

Phase < 1
Waitlist Available
Led By Pavan Parikh, MD
Research Sponsored by University of Oklahoma
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 25-72 hours post-op
Awards & highlights

ERAS Trial Summary

This trial will test whether or not scheduled medications can reduce the risk of persistent opioid use for women after cesarean delivery.

ERAS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~25-72 hours post-op
This trial's timeline: 3 weeks for screening, Varies for treatment, and 25-72 hours post-op for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Amount of morphine milligram equivalents used from 25-72 hours post-op
Patient's morphine milligram equivalent usage from day of discharge to outpatient post-operative visit
Secondary outcome measures
Amount a patient ambulates on post-operative day #2 and #3
Amount of acetaminophen used on post-operative day #2 and #3
Amount of ibuprofen used on post-operative day #2 and #3
+12 more

ERAS Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Study GroupExperimental Treatment1 Intervention
Participants will receive ibuprofen 800mg every eight hours and acetaminophen 1000mg every eight hours, given at the same time, along with oxycodone five mg every six hours PRN for breakthrough pain.
Group II: Standard GroupActive Control1 Intervention
Participants will receive current OU standard of care therapy which includes ibuprofen 800mg every eight hours as needed (PRN), acetaminophen 1000mg every eight hours PRN, and oxycodone five mg every six hours PRN.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ibuprofen, acetaminophen, oxycodone
2020
Completed Early Phase 1
~40

Find a Location

Who is running the clinical trial?

University of OklahomaLead Sponsor
455 Previous Clinical Trials
97,577 Total Patients Enrolled
Pavan Parikh, MDPrincipal InvestigatorUniversity of Oklahoma HSC
1 Previous Clinical Trials
51 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current enrollment size for this clinical trial?

"Affirmative. Clinicaltrials.gov's data confirms that this medical experiment, which was initially posted on December 12th 2020, is presently recruiting patients. Approximately 120 individuals must be enrolled from one trial site."

Answered by AI

Does this research study allow for participants who are older than 50?

"To be considered for this clinical trial, patients must fall between the ages of 18 and 50."

Answered by AI

Is this investigation still recruiting participants?

"According to the clinicaltrials.gov database, this trial is currently in search of participants. It was initially unveiled on December 12th 2020 and amended as recently as May 17th 2022."

Answered by AI

Are there any chronicles of prior experiments examining the effectiveness of ibuprofen, acetaminophen, and oxycodone?

"Currently, 122 medical studies are currently exploring the effects of Ibuprofen, acetaminophen, oxycodone. Of these trials, 35 have progressed to Phase 3 and more than a thousand locations worldwide are running experiments for this medication. The concentration of research is particularly high in Pittsburgh Pennsylvania."

Answered by AI

Could I potentially be a participant in this experiment?

"Successful applicants to this medical study must have undergone a cesarean section, and be between 18-50 years of age. The desired total enrolment is 120 individuals."

Answered by AI

To what ailments are Ibuprofen, acetaminophen, and oxycodone typically prescribed?

"Ibuprofen, acetaminophen, and oxycodone are frequently prescribed to manage catarrh. These medications can also be employed for rhinorrhoea, musculoskeletal pain relief, and muscle spasms treatment."

Answered by AI

What primary goals are this clinical trial aiming to achieve?

"The principle gauge of this trial's success is the amount of morphine milligram equivalents used from 25-72 hours post-operation. Additionally, researchers will also observe patients' ambulation on outpatient day #1-3 by recording their steps with a fitness tracker, measure their satisfaction levels with pain management upon discharge using a line scale in centimeters, and assess perceived readiness to return home through an administered questionnaire."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Towards Enhanced Recovery After Cesarean
2020. "Towards Enhanced Recovery After Cesarean". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04612920.
~8 spots leftby Apr 2025
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