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Active Remote Ischemic Conditioning for Amyotrophic Lateral Sclerosis

N/A
Waitlist Available
Led By Yu-Kuang Wu, PT, PhD
Research Sponsored by Bronx VA Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in averaged oxygen saturation between inflation and deflation phase during active/sham ric.
Awards & highlights

Study Summary

This trial will test the benefits of "Remote ischemic conditioning" (RIC) on people with spinal cord injuries and Amyotrophic lateral sclerosis (ALS). RIC involves temporarily restricting blood flow to a limb to induce the body's systemic defensive reactions. The trial will measure effects on blood pressure, motor neuron excitability, and systemic inflammatory markers before and after RIC.

Eligible Conditions
  • Amyotrophic Lateral Sclerosis
  • Spinal Cord Injury

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in mediator level between baseline measurement and immediately after completion of ric.
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in mediator level between baseline measurement and immediately after completion of ric. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes of Electromyographic responses after RIC plus hand isometric exercise
Secondary outcome measures
Changes of Electromyographic responses 15 mins after RIC plus hand isometric exercise
Changes of Electromyographic responses after RIC but before hand isometric exercise
Inflammatory mediators: the intensity of the gene expression of Toll-like receptor (TLR) signal pathway.
Other outcome measures
Blood pressure
Heart rate
Oxygen saturation

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active RIC + isometric hand exerciseExperimental Treatment2 Interventions
Subjects will receive an active remote ischemic conditioning (200mmHg cuff pressure) before an active isometric hand exercise.
Group II: Sham RIC + isometric hand exercisePlacebo Group2 Interventions
Subjects will receive an sham remote ischemic conditioning (10 mmHg below the subjects' diastolic blood pressure) before an active isometric hand exercise.

Find a Location

Who is running the clinical trial?

Bronx VA Medical CenterLead Sponsor
20 Previous Clinical Trials
1,265 Total Patients Enrolled
2 Trials studying Amyotrophic Lateral Sclerosis
39 Patients Enrolled for Amyotrophic Lateral Sclerosis
Yu-Kuang Wu, PT, PhDPrincipal InvestigatorJames J. Peters VA Medical Center
Noam Y Harel, MD, PhDPrincipal InvestigatorJames J. Peters VA Medical Center
4 Previous Clinical Trials
52 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
F1000ResearchJournal
Effects of Remote Ischemic Conditioning on Hand Engagement in Individuals with Spinal Cord Injury (RICHES): Protocol for a Pilot Crossover Study
Wu, Yu-Kuang, Noam Y. Harel, Jill M. Wecht, and Ona E. Bloom. 2022. “Effects of Remote Ischemic Conditioning on Hand Engagement in Individuals with Spinal Cord Injury (RICHES): Protocol for a Pilot Crossover Study”. F1000research. F1000 Research Ltd. doi:10.12688/f1000research.52670.2.
clinicaltrials.govStudy
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral Sclerosis
Noam Y. Harel 2019. "Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral Sclerosis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03851302.
~4 spots leftby Apr 2025
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