This trial is evaluating whether Active Remote Ischemic Conditioning will improve 1 primary outcome, 3 secondary outcomes, and 3 other outcomes in patients with Amyotrophic Lateral Sclerosis. Measurement will happen over the course of Change in peak-to-peak amplitude between immediately after completion of RIC plus isometric hand exercise and 15 mins after completion of RIC plus isometric hand exercise..
This trial requires 21 total participants across 2 different treatment groups
This trial involves 2 different treatments. Active Remote Ischemic Conditioning is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"SCI can be prevented by timely treatment with corticosteroids. Patients who have SCI may die by the time their SCI is treated, but patients who have a high risk of SCI may also die as a result of that risk. An alternative is to offer surgery so that the patient can receive the benefits of surgery while having a heightened chance of survival. SCI patients can die from other causes, but with appropriate treatment one has a high chance of being cured." - Anonymous Online Contributor
"The type of spinal cord injury has a great influence on the type of treatment required, and may depend on how severe the injury is. The goals of treatment should depend on the severity of the injury and the quality of life a patient may have. Treatments can vary a great deal. Common treatments include inpatient care, home care, rehabilitation, and long-term therapy. In addition this paper presents the medical and surgical treatments that patients receive, their recovery rate, and the prognosis for each case." - Anonymous Online Contributor
"The latest estimates show that there are about 4,200 new SCI cases a year in the United States. However, many individuals with SCIs may never seek health care, and a much higher number of individuals may never be investigated for SCI." - Anonymous Online Contributor
"SCIs is a condition affecting the individual's health and well-being. Spinal cord injury is a major threat to patients that may lead to an inability to walk, move or talk, which can result in a complete loss of independence. It is necessary to have a general knowledge of these conditions, especially how to prevent them in the first place. It is also important to remember that these conditions can be corrected and even alleviated by the use of [treatments] such as a surgical implant, a spinal cord stimulator or a [neural implant]] to improve the quality of life." - Anonymous Online Contributor
"More than 90% of spinal cord injuries reported in the United States are the result of falls from a great height. Of those injuries incurred with falls, 78% occurred in falls from a greater than 8-foot height. The risk of sustaining a spinal cord injury increases significantly as the height of the fall increases." - Anonymous Online Contributor
"Spinal cord injuries can be easily missed, making early diagnosis of patients with [spinal cord injury](https://www.withpower.com/clinical-trials/spinal-cord-injury) difficult, and can lead to severe disability or even death. Nontraumatic causes of spinal cord injury are rare. All patients must be routinely examined for evidence of spondylotic change, decompression, and the assessment of the extent of injury. The use of a bedside radiograph can enhance the identification of spinal canal stenosis." - Anonymous Online Contributor
"This review provides evidence for RIC use in three complementary or dual modality treatments, including multimodality, multiple system diseases, and nonperfusion situations. While it is difficult to infer treatment equivalency due to uncontrolled (unpowered) designs, RIC was shown to provide significant benefit in multiple patient-specific scenarios. Thus, RIC appears to be a promising strategy, providing a promising framework for multimodality applications in clinical practice." - Anonymous Online Contributor
"The mortality rate due to a major spinal cord injury remains high, but progress may be made in the next 10 years, particularly in the development of new clinical treatments." - Anonymous Online Contributor
"In conclusion, common side effects of this IR-pAoP are the subjective and physical discomfort of IR-PC and the objective discomfort of IR-PC+SD. A small number of patients (3/32, 10%) reported that the IR-PC+SD method was painful for them. IR-PC and IR-PC+SD showed no significant difference in the frequency of serious complications." - Anonymous Online Contributor
"None of the clinical trials that have been done has involved this intervention, though there are a few basic principles of how ischemic conditioning will help. Remote ischemic conditioning may help the body regain its ability to ischemia by decreasing the overall amount of ischemia. Ischemic preconditioning, however, has the advantage of taking place on an individual basis before an ischemic event. Remote ischemic conditioning has yet to be studied in any clinical trials." - Anonymous Online Contributor
"Results from a recent paper of this pilot study show that the active form of RIPC produces no significant improvements in walking ability or functional status in individuals with chronic spinal cord injury when compared to passive RIPC or placebo." - Anonymous Online Contributor
"Patients who received the protocol therapy had a significant decrease in SCI-related pain scores that was comparable to those in the control group. Moreover, the therapy did not have any detrimental effects on neurologic recovery. Thus ATRC is considered a safe active procedure that might be considered for future clinical trials to assess efficacy of remote ischemic conditioning as a novel therapeutic strategy for acute pain treatment post SCI." - Anonymous Online Contributor