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Brain Stimulation

active anodal tDCS to ventrolateral prefrontal cortex (VLPFC) for Borderline Personality Disorder

N/A
Waitlist Available
Led By Jeffrey M Miller, MD
Research Sponsored by New York State Psychiatric Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up administered after each (12) tdcs session over 6 days
Awards & highlights

Study Summary

This trial is testing transcranial direct current stimulation (tDCS) as a potential treatment for non-suicidal self-injury (NSSI). NSSI is the deliberate attempt to harm oneself, most often through cutting or burning, without suicidal intent. tDCS is a low-cost, portable, well-tolerated, non-invasive form of brain stimulation that delivers a low current to a specific area of the brain via electrodes. The investigators seek to recruit a sample of 22 individuals who engage in frequent NSSI to complete all study procedures. Subjects will be randomized to receive active- or sham-tDCS for

Eligible Conditions
  • Borderline Personality Disorder
  • Self-Harm
  • Depression
  • Bipolar Disorder
  • Non-Suicidal Self-Injury

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~administered after each (12) tdcs session over 6 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and administered after each (12) tdcs session over 6 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Ecological Momentary Assessment (EMA): NSSI urges and behavior
social processing fMRI task: fMRI responses
tDCS Adverse Effects Questionnaire
Secondary outcome measures
Ecological Momentary Assessment (EMA): affect ratings
social processing fMRI task: emotional responses

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: active anodal tDCS to ventrolateral prefrontal cortex (VLPFC)Active Control1 Intervention
1.5 milliamp (mA) anodal tDCS over right ventrolateral prefrontal cortex; 20-minutes, 6-sessions
Group II: sham anodal tDCS to VLPFCPlacebo Group1 Intervention
Identical electrode montage, sham tDCS over 6 sessions.

Find a Location

Who is running the clinical trial?

New York State Psychiatric InstituteLead Sponsor
475 Previous Clinical Trials
153,892 Total Patients Enrolled
2 Trials studying Borderline Personality Disorder
175 Patients Enrolled for Borderline Personality Disorder
Jeffrey M Miller, MDPrincipal InvestigatorNYSPI
2 Previous Clinical Trials
37 Total Patients Enrolled

Frequently Asked Questions

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Recent research and studies
clinicaltrials.govStudy
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
Jeffrey Miller 2019. "Treating Self Injurious Behavior: A Novel Brain Stimulation Approach". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04244786.
~3 spots leftby Apr 2025
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