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Blood Flow Restriction Therapy for Anterior Cruciate Ligament Rupture (BFR Trial)

N/A
Waitlist Available
Led By Edward Chang, MD
Research Sponsored by Inova Health Care Services
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured preoperatively, at 2-weeks post-op, 6 weeks post-op, and 12 weeks post-op
Awards & highlights

BFR Trial Summary

This trial is testing whether restricting blood flow during rehabilitation after ACL surgery can help prevent muscle atrophy and improve strength and function.

Eligible Conditions
  • Anterior Cruciate Ligament Rupture

BFR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured preoperatively, at 2-weeks post-op, 6 weeks post-op, and 12 weeks post-op
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured preoperatively, at 2-weeks post-op, 6 weeks post-op, and 12 weeks post-op for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Degrees of Knee Extension
Degrees of Knee Flexion
International Knee Documentation Committee (IKDC) Questionnaire Score
+3 more
Secondary outcome measures
Adverse Effects

BFR Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: BFR TherapyExperimental Treatment2 Interventions
This group will undergo physical therapy exercises per the standard of care, with the addition of Blood Flow Restriction (BFR) utilizing a wide pressure cuff. BFR exercises will be initiated two weeks post-op, and continued for 16 weeks.
Group II: No BFRActive Control1 Intervention
This group of patients will undergo physical therapy exercises per the current standard of care after their ACL reconstruction without BFR
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Blood Flow Restriction Therapy
2020
N/A
~150

Find a Location

Who is running the clinical trial?

Inova Health Care ServicesLead Sponsor
69 Previous Clinical Trials
22,206 Total Patients Enrolled
Edward Chang, MDPrincipal Investigator - Orthopedic Surgeon
Inova Alexandria Hospital, Inova Fairfax Hospital
Medical School - Rutgers, The State University of New Jersey, Doctor of Medicine
Thomas Jefferson University Hospital, Residency in Orthopedic Surgery

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
European Journal of Applied PhysiologyJournal
Effect of Multiple Set on Intramuscular Metabolic Stress During Low-intensity Resistance Exercise with Blood Flow Restriction
Suga, Tadashi, Koichi Okita, Shingo Takada, Masashi Omokawa, Tomoyasu Kadoguchi, Takashi Yokota, Kagami Hirabayashi, et al.. 2012. “Effect of Multiple Set on Intramuscular Metabolic Stress During Low-intensity Resistance Exercise with Blood Flow Restriction”. European Journal of Applied Physiology. Springer Science and Business Media LLC. doi:10.1007/s00421-012-2377-x.
Acta Orthopaedica ScandinavicaJournal
Low-load Resistance Muscular Training with Moderate Restriction of Blood Flow After Anterior Cruciate Ligament Reconstruction
Ohta, Haruyasu, Hisashi Kurosawa, Hiroshi Ikeda, Yoshiyuki Iwase, Naohiro Satou, and Shinji Nakamura. 2003. “Low-load Resistance Muscular Training with Moderate Restriction of Blood Flow After Anterior Cruciate Ligament Reconstruction”. Acta Orthopaedica Scandinavica. Medical Journals Sweden AB. doi:10.1080/00016470310013680.
Journal of Science and Medicine in SportJournal
Blood Flow Restricted Exercise for Athletes: A Review of Available Evidence
Scott, Brendan R., Jeremy P. Loenneke, Katie M. Slattery, and Ben J. Dascombe. 2016. “Blood Flow Restricted Exercise for Athletes: A Review of Available Evidence”. Journal of Science and Medicine in Sport. Elsevier BV. doi:10.1016/j.jsams.2015.04.014.
British Journal of Sports MedicineJournal
Blood Flow Restriction Training in Clinical Musculoskeletal Rehabilitation: A Systematic Review and Meta-analysis
Hughes, Luke, Bruce Paton, Ben Rosenblatt, Conor Gissane, and Stephen David Patterson. 2017. “Blood Flow Restriction Training in Clinical Musculoskeletal Rehabilitation: A Systematic Review and Meta-analysis”. British Journal of Sports Medicine. BMJ. doi:10.1136/bjsports-2016-097071.
~8 spots leftby Apr 2025
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