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Intermittent hypoxia for Intermittent Hypoxia

N/A
Waitlist Available
Led By Sophie Lalande
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Men and women aged 18 to 80 years old
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up measured before and 15 minutes after an ischemia-reperfusion injury.
Awards & highlights

Study Summary

The objective of the present study is to determine whether intermittent hypoxia protects against ischemia-reperfusion injury in young and older healthy individuals. The investigators hypothesize that intermittent hypoxia will attenuate the reduction in flow-mediated dilation following ischemia-reperfusion injury.

Eligible Conditions
  • Intermittent Hypoxia

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~measured before and 15 minutes after an ischemia-reperfusion injury.
This trial's timeline: 3 weeks for screening, Varies for treatment, and measured before and 15 minutes after an ischemia-reperfusion injury. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in endothelial-dependent vasodilation of the brachial artery will be assessed by flow-mediated dilation using an ultrasound machine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Intermittent hypoxiaExperimental Treatment1 Intervention
The intermittent hypoxia protocol will consist of three 4-minute hypoxic cycles (arterial oxygen saturation of 80%) interspersed with 4-minute normoxic cycles.
Group II: Intermittent normoxiaPlacebo Group1 Intervention
The intermittent normoxia protocol will consist of three 4-minute normoxic cycles (compressed air) interspersed with 4-minute normoxic cycles (room air).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intermittent hypoxia
2019
N/A
~100

Find a Location

Who is running the clinical trial?

University of Texas at AustinLead Sponsor
353 Previous Clinical Trials
81,203 Total Patients Enrolled
2 Trials studying Intermittent Hypoxia
57 Patients Enrolled for Intermittent Hypoxia
Sophie LalandePrincipal InvestigatorUT Austin
1 Previous Clinical Trials
30 Total Patients Enrolled

Frequently Asked Questions

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Recent research and studies
CirculationJournal
Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a K <sub>atp</sub> Channel–dependent Mechanism
Loukogeorgakis, Stavros P., Rupert Williams, Anna T. Panagiotidou, Shyamsunder K. Kolvekar, Ann Donald, Tim J. Cole, Derek M. Yellon, John E. Deanfield, and Raymond J. MacAllister. 2007. “Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a K atp Channel–dependent Mechanism”. Circulation. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/circulationaha.106.653782.
clinicaltrials.govStudy
Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals
Sophie Lalande 2019. "Effect of Intermittent Hypoxia on Ischemia-reperfusion Injury in Healthy Individuals". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05423470.
~7 spots leftby Apr 2025
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