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Maternal Hyperoxygenation for Fetal Congenital Heart Defects (MATCH Trial)
Phase 1 & 2
Waitlist Available
Led By Mike Seed, MD
Research Sponsored by The Hospital for Sick Children
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Diagnosis of fetus with a single ventricular ventricular heart
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
MATCH Trial Summary
This trial looks at whether it's safe and feasible to give oxygen to pregnant women whose fetuses have heart defects.
Who is the study for?
This trial is for pregnant women between 20-32 weeks gestation, delivering at Mount Sinai Hospital, whose fetus has been diagnosed with a single ventricle heart defect. Women must not be smokers, have a BMI over 37.0, or have serious cardiorespiratory conditions.Check my eligibility
What is being tested?
The study is testing the safety and effectiveness of giving extra oxygen to mothers during pregnancy to see if it helps babies with congenital heart defects before they're born.See study design
What are the potential side effects?
Since this is a pilot study focusing on maternal hyperoxygenation, potential side effects might include dryness of the throat or nasal passages from the oxygen mask and fatigue.
MATCH Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My unborn baby has been diagnosed with a single ventricle heart condition.
MATCH Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
The duration of oxygen therapy tolerated by the subjects
The general condition of the child and mother at the time of birth
MATCH Trial Design
1Treatment groups
Experimental Treatment
Group I: PilotExperimental Treatment1 Intervention
Maternal Hyperoxygenation (4L/min via nasal prongs)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oxygen
FDA approved
Find a Location
Who is running the clinical trial?
The Hospital for Sick ChildrenLead Sponsor
685 Previous Clinical Trials
6,944,983 Total Patients Enrolled
1 Trials studying Hypoplastic Left Heart Syndrome
Mike Seed, MDPrincipal InvestigatorThe Hospital for Sick Children
1 Previous Clinical Trials
3 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You smoke cigarettes.I have serious heart or lung health issues.You are between 5 to 7 months pregnant.I do not have any current infections or anemia.You have a body mass index (BMI) higher than 37.I am choosing to end my pregnancy or receive comfort care.My unborn baby has been diagnosed with a single ventricle heart condition.
Research Study Groups:
This trial has the following groups:- Group 1: Pilot
Awards:
This trial has 2 awards, including:- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are people currently signing up for this experiment?
"From what is indicated on clinicaltrials.gov, this particular trial is still recruiting individuals for participation. The original posting was on February 2nd, 2018 with the most recent edit taking place on October 25th, 2022."
Answered by AI
What do medical professionals use Maternal Hyperoxygenation to treat?
"Maternal Hyperoxygenation can improve maternal and fetal outcomes in cases of severe hypoxemia, anemia, and malignancies."
Answered by AI
How many people fit the qualifications to join this experiment?
"That is correct, the online information available indicates that this study is still enrolling patients. The clinical trial was posted on February 2nd, 2018 and updated as recently as October 25th, 2022. There is a need for 20 more participants at 1 location."
Answered by AI
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