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Expiratory Muscle Strength Testing (EMST) for Amyotrophic Lateral Sclerosis

N/A
Waitlist Available
Led By David Walk, MD
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 0, week 6, week 8, week 10, and week 12
Awards & highlights

Study Summary

This trial is investigating whether expiratory muscle strength training and lung volume recruitment improve breathing, swallowing, speech, and cough function in people with mild to moderate ALS.

Eligible Conditions
  • Amyotrophic Lateral Sclerosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 0, week 6, week 8, week 10, and week 12
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 0, week 6, week 8, week 10, and week 12 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Peak Cough Flow
Secondary outcome measures
Eating Assessment Tool - 10 (EAT-10)
Forced Vital Capacity
Maximal Expiratory Pressure
+2 more

Trial Design

2Treatment groups
Active Control
Group I: Expiratory Muscle Strength Testing (EMST)Active Control1 Intervention
EMST is a treatment method that has been used to improve cough function and swallowing in ALS. EMST uses a training device that has a valve set to 50% of a patient's maximum expiratory pressure (MEP). The patient exhales forcefully until the valve releases. Patients perform 5 sets of 5 repetitions a day, 5 days a week.
Group II: EMST + Lung Volume Recruitment (LVR)Active Control1 Intervention
EMST is a treatment method that has been used to improve cough function and swallowing in ALS. EMST uses a training device that has a valve set to 50% of a patient's maximum expiratory pressure (MEP). The patient exhales forcefully until the valve releases. Patients perform 5 sets of 5 repetitions a day, 5 days a week. LVR is a technique to increase cough function that is performed with a resuscitation bag fitted with a mouthpiece and a one-way valve. The bag is used to expand the lungs, after which the patient makes a voluntary cough.

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,377 Previous Clinical Trials
1,588,273 Total Patients Enrolled
3 Trials studying Amyotrophic Lateral Sclerosis
5,030 Patients Enrolled for Amyotrophic Lateral Sclerosis
David Walk, MDPrincipal InvestigatorUniversity of Minnesota
2 Previous Clinical Trials
30 Total Patients Enrolled
1 Trials studying Amyotrophic Lateral Sclerosis
30 Patients Enrolled for Amyotrophic Lateral Sclerosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS
2018. "Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03202017.
~3 spots leftby Apr 2025
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