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Potassium Chloride for High Blood Pressure (PITCH Trial)

N/A
Recruiting
Led By Joshua D Bundy, PhD, MPH
Research Sponsored by Tulane University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

PITCH Trial Summary

This trial will test how much potassium is needed to lower blood pressure in people with high blood pressure.

Who is the study for?
Adults over 18 with stage 1 hypertension (untreated systolic BP 130-139 and diastolic BP <90 mm Hg) can join. Excluded are those with certain medical conditions like heart failure, kidney disease, diabetes; high serum potassium or bicarbonate levels; heavy alcohol users; pregnant or breastfeeding women; and those on medications affecting potassium levels.Check my eligibility
What is being tested?
The PITCH study is examining how different amounts of potassium supplementation affect blood pressure in adults with stage 1 hypertension. Participants will receive either Potassium Chloride supplements or a placebo to determine the optimal level for lowering blood pressure.See study design
What are the potential side effects?
While not explicitly listed, potential side effects from Potassium Chloride may include stomach discomfort, diarrhea, nausea, vomiting, and high potassium levels which could lead to heart issues if not monitored.

PITCH Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in 24-hour systolic blood pressure (BP) from baseline to 12 weeks
Secondary outcome measures
Change in 24-hour diastolic blood pressure (BP) from baseline to 12 weeks
Change in daytime (awake) diastolic blood pressure (BP) from baseline to 12 weeks
Change in daytime (awake) systolic blood pressure (BP) from baseline to 12 weeks
+4 more

PITCH Trial Design

4Treatment groups
Active Control
Placebo Group
Group I: Potassium Chloride 30 mmol per dayActive Control1 Intervention
Participants randomized to the 30 mmol per day group will receive 1 potassium chloride tablet (15 mmol strength) twice daily (i.e., 2 tablets per day) for 12 weeks.
Group II: Potassium Chloride 60 mmol per dayActive Control1 Intervention
Participants randomized to the 60 mmol per day group will receive 2 potassium chloride tablets (15 mmol strength) twice daily (i.e., 4 tablets per day) for 12 weeks.
Group III: Potassium Chloride 90 mmol per dayActive Control1 Intervention
Participants randomized to the 90 mmol per day group will receive 3 potassium chloride tablets (15 mmol strength) twice daily (i.e., 6 tablets per day) for 12 weeks.
Group IV: PlaceboPlacebo Group1 Intervention
Participants randomized to the placebo arm will receive 1, 2, or 3 inert placebo tablets twice daily (i.e., 2, 4, or 6 tablets per day) for 12 weeks.

Find a Location

Who is running the clinical trial?

National Institute of General Medical Sciences (NIGMS)NIH
268 Previous Clinical Trials
248,536 Total Patients Enrolled
Tulane UniversityLead Sponsor
115 Previous Clinical Trials
226,278 Total Patients Enrolled
Joshua D Bundy, PhD, MPHPrincipal InvestigatorAssistant Professor

Media Library

Placebo Clinical Trial Eligibility Overview. Trial Name: NCT05758142 — N/A
High Blood Pressure Research Study Groups: Placebo, Potassium Chloride 30 mmol per day, Potassium Chloride 60 mmol per day, Potassium Chloride 90 mmol per day
Placebo 2023 Treatment Timeline for Medical Study. Trial Name: NCT05758142 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research currently enrolling new participants?

"Affirmative. Clinicaltrials.gov reveals that this clinical trial is actively searching for participants, having been initially posted on March 1st 2023 and subsequently revised on February 24th of the same year. A total of 224 individuals need to be recruited from a single site."

Answered by AI

What is the current enrollment for this experiment?

"Yes, according to clinicaltrials.gov, this medical trial is now enrolling patients and has been since March 1st 2023. This study was last modified on February 24th 2023 with the aim of recruiting 224 participants from a single centre."

Answered by AI
~108 spots leftby May 2025