Bone Health Assessment for Cystic Fibrosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines the relationship between bone health and cystic fibrosis in teenagers. Researchers aim to determine if adolescents with cystic fibrosis have increased bone marrow fat and how it might affect their bone strength and overall health. Various imaging techniques will measure bone marrow and density. The study seeks teenagers aged 13 to 20 with cystic fibrosis and pancreatic insufficiency who have not changed their treatment in the last three months. As an unphased study, this trial offers a unique opportunity to enhance understanding of bone health in cystic fibrosis, potentially benefiting future treatments.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover important insights into skeletal health and bone marrow composition in adolescents with cystic fibrosis. Unlike existing treatments that primarily focus on managing lung function and nutritional status, this study investigates how cystic fibrosis impacts bone health, a less understood aspect of the condition. By comparing adolescents with cystic fibrosis to a control group matched for age and other factors, the trial hopes to identify potential differences or changes in bone and marrow health over time. This could lead to new strategies for improving overall health outcomes in young people with cystic fibrosis.
Who Is on the Research Team?
Rebecca Gordon, MD
Principal Investigator
Boston Children's Hospital
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Initial imaging and blood tests to assess bone marrow composition and bone mineral density
Follow-up
Participants are monitored for changes in bone marrow composition and bone mineral density
What Are the Treatments Tested in This Trial?
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
This group will be 36 adolescents, ages 13-20 years old, who have been diagnosed with cystic fibrosis. All participants will have a two study visits approximately one year apart during which the listed diagnostic testing will be performed.
Controls will be matched for age, Tanner staging, BMI percentile, and ancestry. All participants will have a two study visits approximately one year apart during which the listed diagnostic testing will be performed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Boston Children's Hospital
Lead Sponsor
Massachusetts General Hospital
Lead Sponsor
Cystic Fibrosis Foundation
Collaborator
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