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Acetazolamide for Schizophrenia (APTS Trial)
APTS Trial Summary
This trial is testing whether the addition of acetazolamide can improve the symptoms of schizophrenia when used alongside the current standard of care. The trial is double blind, meaning that neither the participants nor the researchers will know who is receiving the acetazolamide until after the trial is over.
APTS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowAPTS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.APTS Trial Design
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Who is running the clinical trial?
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- My schizophrenia symptoms remain severe despite treatment.You have used illegal drugs or abused prescription drugs within the past month, or have had a drug addiction within the past 6 months (excluding nicotine).I have been on a stable dose of my antipsychotic medication for over a month.I have a condition like epilepsy that could make my health unstable.I am not allergic to ACZ and do not have renal acidosis, Addison's disease, or chronic glaucoma.I have never taken ACZ or had an allergic reaction to it.I am between 18 and 55 years old.You have an intellectual disability according to the DSM-5.
- Group 1: Acetazolamide
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many people have signed up for this experiment at most?
"Yes, this is an ongoing study that has been posted since February 1st, 2022. The trial is currently being conducted at 1 location and looking for a total of 60 participants."
How is Acetazolamide typically employed in medicine?
"Acetazolamide is an effective medical intervention for salicylate intoxication, edema, and open angle glaucoma (oag)."
Are there any open positions for volunteers in this experiment?
"Yes, this is an active recruitment. The clinical trial was originally posted on 2/1/2022 and has been continuously recruiting since then. They are enrolling 60 patients at 1 site."
What other precedent is there for using Acetazolamide in medical treatment?
"Acetazolamide is being researched in 17 different clinical trials, 4 of which are Phase 3 studies. The majority of these medical trials take place in Detroit, Michigan, though there are a total of 22 locations running these experiments."
Could I potentially enroll in this clinical trial?
"Sixty individuals that have been diagnosed with schizophrenia and are between 18-55 years old can participate in this trial. More specifically, patients must have a PANSS total score > 60, a Score > 4 on one or more items of the 'positive' syndrome items (P1-P7), and cannot be participating in another randomized controlled clinical trial (RCT). Additionally, the study is open to both men and women who may not tolerate high ACZ dose."
Will this experiment be accessible to elderly patients?
"As this trial's eligibility requirements state, the minimum age for participation is 18 and the maximum age is 55."
Who else is applying?
How old are they?
What portion of applicants met pre-screening criteria?
What site did they apply to?
How many prior treatments have patients received?
Why did patients apply to this trial?
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