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Clip closure + EndoCut for Colon Polyps

N/A
Waitlist Available
Research Sponsored by White River Junction Veterans Affairs Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

Study Summary

This trial will test different methods of closing the mucosal defect after resection to see which one is most effective and has the least risk.

Eligible Conditions
  • Colon Polyps

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With Delayed Bleeding Complications
Secondary outcome measures
Complete Study Polyp Resection Rate
Polyp Recurrence Rate
The Number of Complications Associated With Clip Use
+1 more
Other outcome measures
Measured Factors Associated With Incomplete Resection or Recurrence of Polyps
Measured Factors Associated With Resection Complications

Trial Design

4Treatment groups
Active Control
Group I: Clip closure + EndoCutActive Control1 Intervention
Clipping of the mucosal defect after resection of a ≥20mm non-pedunculated study polyp using clips. Resection is done using the EndoCut electrocautery mode.
Group II: Clip closure + CoagulationActive Control1 Intervention
Clipping of the mucosal defect after resection of a ≥20mm non-pedunculated study polyp using clips. Resection is done using the Coagulation electrocautery mode.
Group III: No clip closure + EndoCutActive Control1 Intervention
No clipping of the mucosal defect after resection of a ≥20mm non-pedunculated study polyp. Resection is done using the EndoCut electrocautery mode.
Group IV: No clip closure + CoagulationActive Control1 Intervention
No clipping of the mucosal defect after resection of a ≥20mm non-pedunculated study polyp. Resection is done using the Coagulation electrocautery mode.

Find a Location

Who is running the clinical trial?

White River Junction Veterans Affairs Medical CenterLead Sponsor
28 Previous Clinical Trials
15,624 Total Patients Enrolled
1 Trials studying Colon Polyps
238 Patients Enrolled for Colon Polyps
Dartmouth CollegeOTHER
81 Previous Clinical Trials
1,414,433 Total Patients Enrolled
Boston Scientific CorporationIndustry Sponsor
720 Previous Clinical Trials
931,765 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
GastroenterologyJournal
Effects of Blended (yellow) Vs Forced Coagulation (blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial
Pohl, Heiko, Ian S. Grimm, Matthew T. Moyer, Muhammad K. Hasan, Douglas Pleskow, B. Joseph Elmunzer, Mouen A. Khashab, et al.. 2020. “Effects of Blended (yellow) Vs Forced Coagulation (blue) Currents on Adverse Events, Complete Resection, or Polyp Recurrence After Polypectomy in a Large Randomized Trial”. Gastroenterology. Elsevier BV. doi:10.1053/j.gastro.2020.03.014.
GastroenterologyJournal
Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial
Pohl, Heiko, Ian S. Grimm, Matthew T. Moyer, Muhammad K. Hasan, Douglas Pleskow, B. Joseph Elmunzer, Mouen A. Khashab, et al.. 2019. “Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial”. Gastroenterology. Elsevier BV. doi:10.1053/j.gastro.2019.03.019.
GastroenterologyJournal
Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial
Pohl, Heiko, Ian S. Grimm, Matthew T. Moyer, Muhammad K. Hasan, Douglas Pleskow, B. Joseph Elmunzer, Mouen A. Khashab, et al.. 2019. “Clip Closure Prevents Bleeding After Endoscopic Resection of Large Colon Polyps in a Randomized Trial”. Gastroenterology. Elsevier BV. doi:10.1053/j.gastro.2019.03.019.
Clinical Gastroenterology and HepatologyJournal
Clip Closure Does Not Reduce Risk of Bleeding After Resection of Large Serrated Polyps: Results from a Randomized Trial
Crockett, Seth D., Mouen Khashab, Douglas K. Rex, Ian S. Grimm, Matthew T. Moyer, Amit Rastogi, Todd A. Mackenzie, et al.. 2022. “Clip Closure Does Not Reduce Risk of Bleeding After Resection of Large Serrated Polyps: Results from a Randomized Trial”. Clinical Gastroenterology and Hepatology. Elsevier BV. doi:10.1016/j.cgh.2021.12.036.
~105 spots leftby Apr 2025
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