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Aerobic Exercise for Breast Cancer (ACTIVATE Trial)

N/A
Waitlist Available
Led By Kristin L Campbell, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-chemotherapy (baseline, week 0), mid-chemotherapy (week 6-9), end of chemotherapy (12-18 weeks post-baseline), follow-up/post-usual care group receiving intervention (24-34 weeks post-baseline),1-year follow-up (52 weeks post-baseline).
Awards & highlights

ACTIVATE Trial Summary

This trial is testing whether aerobic exercise can help prevent or mitigate chemotherapy-related cognitive changes (CRCC) in women with breast cancer.

ACTIVATE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-chemotherapy (baseline, week 0), mid-chemotherapy (week 6-9), end of chemotherapy (12-18 weeks post-baseline), follow-up/post-usual care group receiving intervention (24-34 weeks post-baseline),1-year follow-up (52 weeks post-baseline).
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-chemotherapy (baseline, week 0), mid-chemotherapy (week 6-9), end of chemotherapy (12-18 weeks post-baseline), follow-up/post-usual care group receiving intervention (24-34 weeks post-baseline),1-year follow-up (52 weeks post-baseline). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Neuropsychological Tests
Secondary outcome measures
Change with treatment and maintenance post-treatment in brain function and structure
Change with treatment and maintenance post-treatment in electrical activity of the brain
Change with treatment and maintenance post-treatment in self-reported cognitive function
+1 more
Other outcome measures
Change in exercise behaviour
Change with treatment and maintenance post-treatment in aerobic fitness
Change with treatment and maintenance post-treatment in body composition
+3 more

ACTIVATE Trial Design

2Treatment groups
Experimental Treatment
Group I: Usual Care (Wait-list Control)Experimental Treatment1 Intervention
Participants randomly assigned to UC group will be advised to continue with their regular activities of daily living. Following their chemotherapy, the UC group will receive the exercise intervention (lasting 12 weeks).
Group II: Aerobic ExerciseExperimental Treatment1 Intervention
Participants will complete three supervised aerobic exercise sessions each week using the treadmill, stationary bicycle or elliptical training for the duration of their chemotherapy (12-18 weeks). Aerobic exercise will be performed for 20-40 minutes at 50-75% of heart rate reserve. Participants will wear heart rate monitors during all supervised sessions (Polar Electro Inc., Lake Success, NY) and will be provided with target heart rates that will be individualized using their baseline (i.e., week 0) assessment data. Home-based exercise will be introduced in week 3. For the home-based sessions, participants will be asked to complete at least 1 session per week of 30 minutes of aerobic exercise (an activity of their choosing; e.g., walking).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic Exercise
2013
Completed Early Phase 1
~1310

Find a Location

Who is running the clinical trial?

Canadian Cancer Society (CCS)OTHER
79 Previous Clinical Trials
37,861 Total Patients Enrolled
8 Trials studying Breast Cancer
631 Patients Enrolled for Breast Cancer
Avon FoundationOTHER
13 Previous Clinical Trials
783 Total Patients Enrolled
8 Trials studying Breast Cancer
692 Patients Enrolled for Breast Cancer
University of OttawaOTHER
209 Previous Clinical Trials
267,224 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Aerobic Exercise and Cognitive Functioning in Women With Breast Cancer
Kristin Campbell 2017. "Aerobic Exercise and Cognitive Functioning in Women With Breast Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03277898.
~11 spots leftby May 2025
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