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Botanical Microglia Modulator

Boswellia Serrata for Gulf War Syndrome

N/A
Waitlist Available
Led By Jarred W Younger, PhD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up average disease severity during the last two weeks of each treatment, compared to average severity during the last two weeks of placebo, as well as baseline.
Awards & highlights

Study Summary

The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic inflammation that cannot be measured with typical techniques. The investigators will be observing the effects of nine different botanical compounds (supplements) that are known to suppress inflammation. If one of those supplements helps the symptoms of GWI, it will give the investigators information about what is wrong in people with GWI.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~average mood severity during the last two weeks of each treatment, compared to average severity during the last two weeks of placebo, as well as baseline.
This trial's timeline: 3 weeks for screening, Varies for treatment, and average mood severity during the last two weeks of each treatment, compared to average severity during the last two weeks of placebo, as well as baseline. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline in overall Gulf War Illness disease severity
Secondary outcome measures
Change from baseline in Cognitive Symptom Severity
Change from baseline in Dermatological Symptom Severity
Change from baseline in Fatigue Severity
+4 more

Trial Design

10Treatment groups
Experimental Treatment
Placebo Group
Group I: ResveratrolExperimental Treatment1 Intervention
200-600mg in capsule form by mouth every day
Group II: Reishi MushroomExperimental Treatment1 Intervention
1600-3200mg in capsule form by mouth every day
Group III: PycnogenolExperimental Treatment1 Intervention
200-400mg in capsule form by mouth every day
Group IV: NettleExperimental Treatment1 Intervention
435-1305mg in capsule form by mouth every day
Group V: LuteolinExperimental Treatment1 Intervention
200-400mg in capsule form by mouth every day
Group VI: FisetinExperimental Treatment1 Intervention
200-800mg in capsule form by mouth every day
Group VII: EpimediumExperimental Treatment1 Intervention
1000-2000mg in capsule form by mouth every day
Group VIII: CurcuminExperimental Treatment1 Intervention
1000-2000mg in capsule form by mouth every day
Group IX: Boswellia SerrataExperimental Treatment1 Intervention
400-800mg in capsule form by mouth every day
Group X: PlaceboPlacebo Group1 Intervention
in capsule form by mouth every day
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Reishi Mushroom
2016
N/A
~40
Curcumin
2017
Completed Phase 4
~1050
Epimedium
2016
N/A
~40
Pycnogenol
2016
Completed Phase 3
~160
Luteolin
2016
N/A
~40
Nettle
2016
N/A
~40
Boswellia Serrata
2016
N/A
~40
Resveratrol
2014
Completed Phase 3
~730
Fisetin
2016
Completed Phase 2
~170

Find a Location

Who is running the clinical trial?

Congressionally Directed Medical Research ProgramsFED
48 Previous Clinical Trials
6,737 Total Patients Enrolled
1 Trials studying Gulf War Syndrome
300 Patients Enrolled for Gulf War Syndrome
University of Alabama at BirminghamLead Sponsor
1,590 Previous Clinical Trials
2,281,623 Total Patients Enrolled
2 Trials studying Gulf War Syndrome
354 Patients Enrolled for Gulf War Syndrome
Jarred W Younger, PhDPrincipal InvestigatorUniversity of Alabama at Birmingham
1 Previous Clinical Trials
27 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effects of Botanical Microglia Modulators in Gulf War Illness
Jarred Younger 2016. "Effects of Botanical Microglia Modulators in Gulf War Illness". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02909686.
~4 spots leftby Apr 2025
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