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Carbonic Anhydrase Inhibitor

Methazolamide for Glaucoma

Phase 4
Waitlist Available
Led By Malik Y. Kahook, MD
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1 (pre-dosing, then 4- and 8- hours post dosing), day 7 (pre-dosing, then 4- and 8- hours post dosing), day 14 (pre-dosing, then 4- and 8- hours post dosing)
Awards & highlights

Summary

This trial is testing whether methazolamide can safely and effectively lower intraocular pressure.

Who is the study for?
This trial is for English-reading men and women aged 50 to 90 with open-angle glaucoma in both eyes. It's not for those with other types of glaucoma, severe or end-stage glaucoma, or if they are pregnant or breastfeeding.Check my eligibility
What is being tested?
The study tests methazolamide tablets at doses of 25 mg and 50 mg to lower eye pressure in glaucoma patients. Participants will take one dose daily for a week, then twice daily for another week to assess effectiveness and safety.See study design
What are the potential side effects?
Methazolamide may cause side effects like fatigue, loss of appetite, taste alterations, tingling in hands or feet, diarrhea, kidney stones, and rarely blood cell disorders.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1 (pre-dosing, then 4- and 8- hours post dosing), day 7 (pre-dosing, then 4- and 8- hours post dosing), day 14 (pre-dosing, then 4- and 8- hours post dosing)
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 (pre-dosing, then 4- and 8- hours post dosing), day 7 (pre-dosing, then 4- and 8- hours post dosing), day 14 (pre-dosing, then 4- and 8- hours post dosing) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent IOP change at each follow-up Visit
Secondary outcome measures
Body Weight Changes
Body Weight Changes
Body Weight Changes
+2 more

Trial Design

2Treatment groups
Active Control
Group I: Methazolamide 25 mgActive Control1 Intervention
Once a day [q.d] in the morning for 1 week, Twice a day [b.i.d.] in the morning and evening for 1 week
Group II: Methazolamide 50 mgActive Control1 Intervention
Once a day [q.d] in the morning for 1 week, Twice a day [b.i.d.] in the morning and evening for 1 week

Find a Location

Who is running the clinical trial?

University of Colorado, DenverLead Sponsor
1,758 Previous Clinical Trials
2,166,230 Total Patients Enrolled
Malik Y. Kahook, MDPrincipal InvestigatorUniversity of Colorado, Denver
6 Previous Clinical Trials
175 Total Patients Enrolled
~12 spots leftby Jul 2025
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