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Pembrolizumab for Non-Hodgkin's Lymphoma

Phase 2
Waitlist Available
Led By Philippe Armand, MD, PhD
Research Sponsored by Dana-Farber Cancer Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 18 months
Awards & highlights

Study Summary

This trial is testing if a new immunotherapy drug can help people with lymphoma who are in remission.

Eligible Conditions
  • Non-Hodgkin's Lymphoma
  • Peripheral T-Cell Lymphoma
  • Hodgkin's Lymphoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression-free Survival After ASCT
Secondary outcome measures
Overall Survival
Progression-free Survival
Relapse
+2 more
Other outcome measures
Completion Rate
Minimal Residual Disease
Overall Survival After ASCT by PET Status
+1 more

Side effects data

From 2024 Phase 2 trial • 57 Patients • NCT03004183
21%
Fatigue
13%
Nausea
11%
Back pain
9%
Shortness of Breath
9%
Anemia
9%
Abdominal pain
9%
Diarrhea
7%
Pneumonia
7%
Kidney Injury and/or Infection
7%
Dyspnea
7%
Weight Loss
5%
Malnutrition, Hypercalcemia and Weakness
5%
Pneumothorax
5%
Intractable pain, back pain, hip pain
5%
Activated partial thromboplastin time prolonged
4%
Pleural effusion
4%
Atrial fibrillation with rapid ventricular response
2%
Thrombocytopenia
2%
Respiratory failure
2%
Skin rash
2%
colitis
100%
80%
60%
40%
20%
0%
Study treatment Arm
Single Arm

Trial Design

3Treatment groups
Experimental Treatment
Group I: Peripheral T cell lymphomaExperimental Treatment1 Intervention
Pembrolizumab 200mg IV every 3 weeks up to 8 cycles
Group II: Diffuse large B cell lymphomaExperimental Treatment1 Intervention
Pembrolizumab 200mg IV every 3 weeks up to 8 cycles
Group III: Classical Hodgkin lymphomaExperimental Treatment1 Intervention
Pembrolizumab 200mg IV every 3 weeks up to 8 cycles
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pembrolizumab
2017
Completed Phase 2
~2010

Find a Location

Who is running the clinical trial?

Merck Sharp & Dohme LLCIndustry Sponsor
3,888 Previous Clinical Trials
5,055,001 Total Patients Enrolled
Dana-Farber Cancer InstituteLead Sponsor
1,079 Previous Clinical Trials
340,904 Total Patients Enrolled
Philippe Armand, MD, PhDPrincipal InvestigatorDana-Farber Cancer Institute
4 Previous Clinical Trials
212 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any short-term dangers to taking Pembrolizumab?

"Pembrolizumab's safety is rated as a 2. This is due to the lack of efficacy data, as this is only a Phase 2 trial."

Answered by AI

What are some other trials that have used Pembrolizumab?

"Pembrolizumab is being trialed in 1000 active clinical studies, 122 of which are Phase 3. The majority of these trials take place in Houston, Texas; however, there are 36030 locations running Pembrolizumab trials globally."

Answered by AI

Are participants being enrolled in this research at present?

"As of July 26th, 2022 this trial is no longer admitting patients. It was initially posted on April 1st, 2015. There are currently 1844 trials for lymphoma and Hodgkin's disease and 1000 trials for Pembrolizumab that are actively recruiting patients."

Answered by AI

What are some of the primary indications for Pembrolizumab?

"Pembrolizumab is a standard treatment for malignant neoplasms. Additionally, this medication can be used to target other conditions like unresectable melanoma and microsatellite instability high."

Answered by AI

How many people are enrolling in this trial?

"This study is not presently looking for new participants. However, it's worth noting that the trial was last updated on 7/26/2022 and initially posted on 4/1/2015. Additionally, there are 1844 other trials related to lymphoma and hodgkins actively recruiting patients as well as 1000 studies concerning Pembrolizumab."

Answered by AI

Which medical facilities are conducting this research project?

"Currently, there are six sites where this trial is taking place. For example, Beth Israel Deaconess Medical Center in Boston, Memorial Sloan Kettering Cancer Center in New york, and City of Hope National Medical Center in Duarte. There are also three other locations."

Answered by AI
Recent research and studies
~8 spots leftby Apr 2025