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NMDA Receptor Antagonist

Active Drug for Chronic Pain (Ketamine Trial)

Phase 3
Waitlist Available
Led By Lucinda Grande, MD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights

Ketamine Trial Summary

This project is a pilot study to evaluate the analgesic and opioid-sparing effects of ketamine in an ultra-low dose oral formulation as a novel intervention for treatment of chronic non-cancer pain in opioid-tolerant patients in the primary care outpatient setting.

Ketamine Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Function improvement (BPI Mean Interference Scale)
Pain improvement (Brief Pain Inventory (BPI) Mean Pain Severity Scale)
Secondary outcome measures
Reduction in opioid use (self-reported average opioid dose)
Other outcome measures
Mental Depression

Ketamine Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Active DrugActive Control1 Intervention
ketamine 16 mg in flavored syrup by mouth twice daily for 1 week, then ketaming 32 mg in flavored syrup by mouth twice daily for 1 week
Group II: PlaceboPlacebo Group1 Intervention
Flavored syrup (without ketamine) by mouth twice daily for 2 weeks

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,743 Previous Clinical Trials
1,847,838 Total Patients Enrolled
40 Trials studying Chronic Pain
17,345 Patients Enrolled for Chronic Pain
Lucinda Grande, MDPrincipal InvestigatorUniversity of Washington Department of Family Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting
Lucinda Grande 2014. "Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02303847.
All > American Chronic Pain
~3 spots leftby May 2025
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