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Electrical Stimulation

tDCS for Cognitive Enhancement (MINUTES Trial)

N/A
Recruiting
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 - 60 years old.
Age 18 - 60 years old.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline; mid-test (week 6); post-test (week 12);follow up (week 24).
Awards & highlights

MINUTES Trial Summary

This trial will test transcranial direct current stimulation (tDCS) as a tool to improve cognition in healthy people and people with schizophrenia. tDCS sends a low current through the brain to stimulate or modulate neuronal activity. This study will test whether tDCS can increase cognitive abilities and whether these increases generalize to other domains.

Who is the study for?
Healthy individuals aged 18-60, with an IQ between 70 and 115, who can commit to three weekly training sessions over 12 weeks and four assessments. They must not have serious mental illnesses or addictive disorders, sleep disorders, or any medical condition affecting the brain like a stroke.Check my eligibility
What is being tested?
The study is testing how transcranial direct current stimulation (tDCS) affects cognitive function when paired with cognitive training. It will explore changes in brain connectivity in healthy subjects over a period of 12 weeks using different tDCS settings.See study design
What are the potential side effects?
Potential side effects of tDCS may include mild itching, tingling on the scalp during application, headache, fatigue after treatment sessions. Serious side effects are rare but could involve seizures if predisposed.

MINUTES Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 60 years old.
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I am between 18 and 60 years old.
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I can attend three 45-minute training sessions weekly for 12 weeks and go through four assessments.

MINUTES Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline; mid-test (week 6); post-test (week 12);follow up (week 24).
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline; mid-test (week 6); post-test (week 12);follow up (week 24). for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in DPX task performance
Changes in Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) composite score
Changes in N-back task performance
+3 more

MINUTES Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: right active-tDCSExperimental Treatment1 Intervention
2-3 times/week for 12 weeks: ramp-up for 30 seconds, 2mA right (AF4 anode - AF3 cathode) for 20 min, and then ramp-down for 30 seconds.
Group II: left active-tDCSExperimental Treatment1 Intervention
2-3 times/week for 12 weeks: ramp-up for 30 seconds, 2mA left (AF3 anode - AF4 cathode) for 20 min, and then ramp-down for 30 seconds.
Group III: sham tDCSPlacebo Group1 Intervention
Current will be turned off immediately after the initial 30-second ramp-up period.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial direct current stimulation (tDCS)
2016
Completed Phase 3
~820

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,778 Previous Clinical Trials
2,674,417 Total Patients Enrolled
2 Trials studying Transcranial Direct Current Stimulation
208 Patients Enrolled for Transcranial Direct Current Stimulation
University of MinnesotaLead Sponsor
1,372 Previous Clinical Trials
1,588,096 Total Patients Enrolled
1 Trials studying Transcranial Direct Current Stimulation
85 Patients Enrolled for Transcranial Direct Current Stimulation

Media Library

Transcranial Direct Current Stimulation (tDCS) (Electrical Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT03896425 — N/A
Transcranial Direct Current Stimulation Research Study Groups: right active-tDCS, sham tDCS, left active-tDCS
Transcranial Direct Current Stimulation Clinical Trial 2023: Transcranial Direct Current Stimulation (tDCS) Highlights & Side Effects. Trial Name: NCT03896425 — N/A
Transcranial Direct Current Stimulation (tDCS) (Electrical Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03896425 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical trial restrict participation to those over 85 years of age?

"This specific trial requires patients to be between 18 and 60 years of age. Additionally, there are 54 trials open for minors and 380 studies available for those above the retirement age."

Answered by AI

How many participants are being monitored within this experiment?

"Affirmative. According to the information on clinicaltrials.gov, this trial is currently looking for participants and has been since April 1st 2019. As of October 28th 2022, 90 patients need to be recruited from a single centre in order for it to continue."

Answered by AI

To what kind of participants is this research initiative suited?

"This medical trial is searching for 90 people, aged 18 to 60 and with current transcranial direct current stimulation. Participants must also abide by the following conditions: possess an IQ between 70-115; demonstrate informed consent capability; have no severe or persistent mental illness (SPMI) nor addictive disorder as evaluated via MINI International Neuropsychiatric Interview; attend three 45 minute training sessions over 12 weeks and participate in four assessments."

Answered by AI

Are there any enrollment opportunities for individuals at this stage of the experiment?

"Affirmative. The information found on clinicaltrials.gov conveys that the medical trial, which was initially posted in April 2019, is actively searching for participants. Approximately 90 individuals must be enrolled at one site to complete the study."

Answered by AI

Who else is applying?

What state do they live in?
California
Minnesota
How old are they?
18 - 65
What site did they apply to?
University of Minnesota
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

I'm looking for healthy study volunteer trials to volunteer for.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. University of Minnesota: < 48 hours
Average response time
  • < 2 Days
~15 spots leftby Apr 2025