Transcranial direct current stimulation (tDCS) for Transcranial Direct Current Stimulation

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Transcranial Direct Current Stimulation+1 More
Transcranial direct current stimulation (tDCS) - Device
Eligibility
18 - 65
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test transcranial direct current stimulation (tDCS) as a tool to improve cognition in healthy people and people with schizophrenia. tDCS sends a low current through the brain to stimulate or modulate neuronal activity. This study will test whether tDCS can increase cognitive abilities and whether these increases generalize to other domains.

Eligible Conditions
  • Transcranial Direct Current Stimulation
  • Healthy Subjects (HS)

Treatment Effectiveness

Study Objectives

6 Primary · 0 Secondary · Reporting Duration: baseline; mid-test (week 6); post-test (week 12);follow up (week 24).

Week 12
Changes in thalamocortical functional connectivity (FC)
Week 12
Changes in DPX task performance
Changes in N-back task performance
Dual-Energy X-Ray Absorptiometry
Changes in task-dependent thalamocortical functional connectivity (fMRI) during the N-back task.
Week 24
Changes in Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) composite score

Trial Safety

Trial Design

3 Treatment Groups

left active-tDCS
1 of 3
right active-tDCS
1 of 3
sham tDCS
1 of 3
Experimental Treatment
Non-Treatment Group

90 Total Participants · 3 Treatment Groups

Primary Treatment: Transcranial direct current stimulation (tDCS) · Has Placebo Group · N/A

left active-tDCS
Device
Experimental Group · 1 Intervention: Transcranial direct current stimulation (tDCS) · Intervention Types: Device
right active-tDCS
Device
Experimental Group · 1 Intervention: Transcranial direct current stimulation (tDCS) · Intervention Types: Device
sham tDCS
Device
ShamComparator Group · 1 Intervention: Transcranial direct current stimulation (tDCS) · Intervention Types: Device
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial direct current stimulation (tDCS)
2016
Completed Phase 3
~710

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline; mid-test (week 6); post-test (week 12);follow up (week 24).

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,522 Previous Clinical Trials
1,814,500 Total Patients Enrolled
2 Trials studying Transcranial Direct Current Stimulation
213 Patients Enrolled for Transcranial Direct Current Stimulation
University of MinnesotaLead Sponsor
1,239 Previous Clinical Trials
1,460,588 Total Patients Enrolled
1 Trials studying Transcranial Direct Current Stimulation
90 Patients Enrolled for Transcranial Direct Current Stimulation

Eligibility Criteria

Age 18 - 65 · All Participants · 5 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
The IQ range is estimated to be between 70 and 115.
Ability to provide consent and comply with study procedures.
People who are 18 to 60 years old can use this product.
No significant mental illness or addiction, as measured by the MINI, and no sleep disorder.
The person is able to attend three 45-minute training sessions per week for 12 weeks, and also participates in four assessments.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 14th, 2021

Last Reviewed: October 23rd, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

Who else is applying?

What state do they live in?
California100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
University of Minnesota100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%