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Virus Therapy

VLP-encapsulated TLR9 Agonist CMP-001 for Pancreatic Cancer

Phase 1 & 2
Waitlist Available
Led By Diana L Hanna, MD
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 years
Awards & highlights

Study Summary

This trial is testing CMP-001, a DNA-based immunotherapy, in combination with INCAGN01949, an antibody that stimulates the immune system, to treat patients with stage IV pancreatic cancer and other advanced cancers.

Eligible Conditions
  • Stage IV Pancreatic Cancer
  • Solid Tumors
  • Pancreatic Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Disease control rate (Phase II)
Objective response rate (CR + PR)
Secondary outcome measures
Incidence of adverse events
Overall survival
Progression free survival (PFS)
Other outcome measures
Amplification and characterization of T cell receptor (TCR) a and b sequences of tumor-infiltrating T cells
Enumeration of CD4+ and CD8+ T cell subsets
Expression of activation/differentiation markers on CD4+ and CD8+ T cell subsets
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment (CMP-001, INCAGN01949)Experimental Treatment2 Interventions
Patients receive CMP-001 SC on day 1 of weeks 1 and 2 and IT on day 1 of weeks 3-6 in the absence of disease progression or unacceptable toxicity. Patients also receive INCAGN01949 IT on day 1 of weeks 3-6 in the absence of disease progression or unacceptable toxicity.

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,151 Total Patients Enrolled
University of Southern CaliforniaLead Sponsor
905 Previous Clinical Trials
1,596,316 Total Patients Enrolled
Diana L Hanna, MDPrincipal InvestigatorUniversity of Southern California

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients currently being sought for this clinical trial?

"That is accurate, the website clinicaltrials.gov has information stating that this research is actively recruiting participants. The study was originally posted on 4/29/2021 and was last edited on 6/1/2022. The researchers conducting this trial are looking for 42 individuals total from 4 different locations."

Answered by AI

Are there any other areas of the country where this trial is taking place?

"Currently, this trial is running at HonorHealth Research Institute in Scottsdale, USC / Norris Comprehensive Cancer Center in Los Angeles, Hoag Memorial Hospital in Newport Beach, and 4 other locations."

Answered by AI

How many patients are going to be participating in this clinical trial?

"Yes, that is accurate. The listing on clinicaltrials.gov shows that the study is still looking for participants. This trial was first posted on April 29th 2021 and updated June 1st of this year. They are enrolling 42 patients total at 4 different sites."

Answered by AI

Who else is applying?

What site did they apply to?
Hoag Memorial Hospital
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
CMP-001 and INCAGN01949 for Patients With Stage IV Pancreatic Cancer and Other Cancers Except Melanoma
2021. "CMP-001 and INCAGN01949 for Patients With Stage IV Pancreatic Cancer and Other Cancers Except Melanoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04387071.
~1 spots leftby Apr 2025
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