This trial is evaluating whether CPO107 will improve 1 primary outcome and 4 secondary outcomes in patients with Lymphoma. Measurement will happen over the course of through study completion, an average of 1 year.
This trial requires 75 total participants across 3 different treatment groups
This trial involves 3 different treatments. CPO107 is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"Lymphoid Leukemia and Lymphoma may be caused by the same genetic mechanisms. This finding suggests a common cause for the development of all forms of lymphoma. These data suggest a possible contribution of some types of infectious agents (especially retroviral infections) to development of lymphoma." - Anonymous Online Contributor
"There are several factors that are significant in determining the prognosis of lymphoma patients. The most important factors are the type of cancer, staging of cancer, the staging of lymphoma, the level of performance status, gender, and age." - Anonymous Online Contributor
"Most often, lymphomas are treated with chemotherapy with or without steroids and/or targeted agents. However, the course of some lymphomas may be self-limiting and there is little evidence to support the use of radiation or immunotherapy.\n" - Anonymous Online Contributor
"Those with signs of lymphoma tend to present with a single site of disease, are more likely to be male, and have disseminated disease at presentation. They are also more likely to have other medical diagnoses (other than lymphoma), and are less likely to receive appropriate therapy for lymphoma. As many as 80% of all newly diagnosed lymphomas involve the lungs (pleural) or the lymph nodes (mediastinal)." - Anonymous Online Contributor
"There are an average of 2.1 new cases of lymphoma for every 100,000 people per year. In 2009, around 26,800 people were diagnosed with lymphoma. Lymphoma is the most common cancer in men and women diagnosed in 2009. People of Caucasian ethnicity and older people were more likely to be diagnosed with lymphoma in 2008 than in 1998." - Anonymous Online Contributor
"Lymphoma is a group of blood cancers that involve the white cells that are part of the immune system. It is diagnosed either by imaging tests or biopsy. Most cases are curable and can be treated, but a number of lymphomas are not. The most common types are non-Hodgkin's lymphoma, large non-Hodgkin's lymphoma, MALT lymphoma and follicular lymphoma." - Anonymous Online Contributor
"Although recent progress has been made in understanding lymphoma mechanisms, there is still a lack of knowledge about key cell pathways, and this knowledge is likely to be essential to developing the next generation of lymphoma treatments. The current treatment algorithms and chemotherapies used in lymphoma-related cases may have limitations and have adverse impacts on patients’ quality of life." - Anonymous Online Contributor
"Cpo-107, a first-in-class small molecule inhibitor of the human Cpo-receptor, is safe and well tolerated in healthy volunteers and patients with relapsed follicular lymphoma with good antitumour activity." - Anonymous Online Contributor
"CPO107 can improve QoL in patients with NHL. The use of CPO107 is safe, tolerable, and has potential clinical and cost savings, suggesting that more patients could be treated effectively." - Anonymous Online Contributor
"The risk of being undertreated by trial participation may outweigh any potential benefit. Patients with newly diagnosed lymphoma should be informed of the risks of being undertreated, as well as trial options, with the goal of shared decision-making, in order to optimise patient outcomes." - Anonymous Online Contributor
"Symptoms of cpo107 can include constipation, nausea, anorexia, vomiting, diarrhea, headache, miosis. There is also a high risk that some of the patients who reported these side effects actually did not have this side effect. Therefore, some of the patients who complain about side effects may not actually have the side effect of cpo107 in question." - Anonymous Online Contributor
"In recent years, the world is changing dramatically from a rural to an urbanized society. This trend is already present in Finland as the population moves closer to the city center. Over the last decade there has been rapid population growth, and in Finland, there is a corresponding rise in tuberculosis cases. This suggests a new factor as the most likely cause of lymphoma: TB. This is the first time a link has been established between tuberculosis and lymphoma, and it is certainly not a rare event. But there is no conclusive evidence supporting a relationship between lymphoma and tuberculosis." - Anonymous Online Contributor