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Chemotherapy + Allopurinol + Mycophenolate for Small Cell Lung Cancer
Study Summary
This trial is testing whether adding mycophenolate mofetil and allopurinol to chemotherapy drugs used for relapsed small cell lung cancer will improve outcomes compared to using other single agent chemotherapy drugs.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2014 Phase 3 trial • 87 Patients • NCT00075478Trial Design
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Who is running the clinical trial?
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- I have active hepatitis C.I have side effects from past treatments, but they are not severe except for tiredness, hormone issues treated with medication, or hair loss.I do not have active infections and can receive immunosuppressive treatment.I am 18 years old or older.My blood tests for bone marrow and organ function are normal.I am not on any experimental drugs, or it has been 3 weeks since my last dose.I am on medication for a chronic diarrheal illness like IBD.I have a significant liver condition.I haven't taken any antibiotics by mouth or IV in the last 2 weeks.I can take care of myself but might not be able to do heavy physical work.I have active tuberculosis.My small cell lung cancer worsened after treatment with platinum-based chemo and anti-PD-L1.I have had cancer before, but I am currently cancer-free and it's not likely to affect my survival.You have had a bad reaction to irinotecan in the past.You have been diagnosed with HIV.I am not taking any strong CYP3A4 inducers or inhibitors.You have a history of a current autoimmune disease.I do not have symptoms from brain metastases.I am allergic to medications similar to MMF, allopurinol, or others used in this study.I have not had major surgery in the last 28 days or minor surgery in the last 7 days.I have lung inflammation needing treatment or extra oxygen.I have active hepatitis B.I have not needed IV antibiotics in the last 2 weeks.You have a disease that can be measured using specific criteria.
- Group 1: Phase I Dose Level 1a: MMF + Irinotecan + Allopurinol
- Group 2: Phase I Dose Level 1: MMF + Irinotecan + Allopurinol
- Group 3: Phase II: MMF + Irinotecan + Allopurinol
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the primary health conditions for which Mycophenolate Mofetil is prescribed?
"Mycophenolate Mofetil is widely employed to combat kidney transplant rejection, yet can also be applied in the treatment of colorectal carcinoma, ovarian cancer, and various sarcoma cases."
Are there any opportunities to join the current clinical trial?
"Clinicaltrials.gov states that this particular research project is no longer enrolling participants, with its initial post dated February 28th 2023 and the latest update from October 26th 2022. Nonetheless, there are 1,971 other clinical trials actively seeking candidates at present."
What other empirical examinations have been conducted using Mycophenolate Mofetil?
"Presently, 399 clinical trials are investigating the effects of Mycophenolate Mofetil. Of these 399 studies, 72 have advanced to Phase 3 testing. Although most research is being conducted in Philadelphia, Pennsylvania, there are 9493 sites conducting such investigations."
How many participants are included in this research endeavor?
"Unfortunately, this trial is not open for recruitment at present. It was initially posted on February 28th 2023 and the most recent update occurred October 26th 2022. However, if you are seeking alternative trials, 1572 studies are actively looking for patients suffering from small cell lung carcinoma and 399 trials recruiting participants who take Mycophenolate Mofetil."
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