Tirofiban Hydrochloride for Ischemia

Phase-Based Estimates
1
Effectiveness
1
Safety
University of Iowa Hospitals and Clinics, Iowa City, IA
Ischemia+4 More
Tirofiban Hydrochloride - Drug
Eligibility
18+
All Sexes
Eligible conditions
Ischemia

Study Summary

This study is evaluating whether a medication may help improve outcomes for individuals who have had a stroke.

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Eligible Conditions

  • Ischemia
  • Wake-up Stroke
  • Stroke
  • Cerebral Infarction
  • Stroke, Acute, Stroke Ischemic
  • Ischemic Stroke

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Tirofiban Hydrochloride will improve 2 primary outcomes and 2 secondary outcomes in patients with Ischemia. Measurement will happen over the course of Up to 2 weeks post enrollment.

Day 90
Modified Rankin Score
NIH Stroke Scale
Week 2
Infract Size
Intracranial Hemorrhage

Trial Safety

Trial Design

2 Treatment Groups

Placebo Arm
Treatment Arm (tirofiban hydrochloride (AGGRASTAT®))
Placebo group

This trial requires 60 total participants across 2 different treatment groups

This trial involves 2 different treatments. Tirofiban Hydrochloride is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.

Treatment Arm (tirofiban hydrochloride (AGGRASTAT®))
Drug
Subjects will receive an active dose via continuous IV at a rate of 0.10µg/kg/min (actual weight). This rate will begin within one hour of mechanical thrombectomy completion and will be terminated 24 hours after the initial administration time.
Placebo Arm
Drug
Subjects will receive placebo (saline) via continuous IV. This will begin within one hour of mechanical thrombectomy completion and will be terminated 24 hours after the initial administration time.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 90 day post- discharge follow up
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 90 day post- discharge follow up for reporting.

Who is running the study

Principal Investigator
D. H.
David Hasan, Principal Investigator
University of Iowa

Closest Location

University of Iowa Hospitals and Clinics - Iowa City, IA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
usually The onset of AIS usually happens 6-24 hours after the injury. show original
The prostate can be imaged by MRI. show original
The patient or their legally authorized representative has given written permission for the procedure. show original
Age ≥ 18 and ≤ 90 years
Acute ischemic stroke (AIS)
NIHSS score ≥ 6
AIS due to LVO
The patient has a core infarct of less than 30cc or an ASPECT score of 6 or higher. show original
I received the MT per SOC show original
This text is about a patient who has a TICI score of 2B, or a TC post MT. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes ischemia?

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Ischemia results from reduced blood flow to a part of the body or when the arteries supplying that part are blocked. It can occur temporarily as a result of a heart attack, or permanently. A blocked artery can be caused by a blood clot, an abnormality of the artery wall, or a tumor.\nKey Points\n- Ischemia, or lack of oxygen to tissue, can result from either inadequate blood flow to an area, poor blood perfusion to an area, or when the arteries supplying this area and the blood flowing through it are blocked.

Unverified Answer

What are the signs of ischemia?

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In a cardiac arrest, there are 3 crucial and overlapping steps of brain stem ischemia: ischemia, hypoxia, and hypoperfusion. The signs of ischemia: asymmetric brain stem tone, abnormal level or pattern of eye movement and pupils, as well as absent or low blood pressure are the main manifestations. An important finding in the prehospital period is the need of monitoring the level of hemoglobin, carboxyhemoglobin, lactate, and base deficit of blood. We suggested that an S1 heart sound is indispensable in prehospital emergency situations.

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How many people get ischemia a year in the United States?

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The number of angina symptoms and symptoms associated with myocardial ischemia vary a great deal among US populations. Because of the variability of angina symptoms and the relatively low percentage of cases with significant ischemia, we believe it is important and meaningful to report the number of cases of major ischemia and their associated symptoms. It is also important to compare the results of different populations to estimate the true number of cases of ischemia per year. We estimated the annual incidence of severe ischemia in the United States and determined the incidence of symptoms associated with ischemia in seven major population samples. Although the incidence is greatest in those most vulnerable to ischemia, its influence on total population-wide burden can be substantial.

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What are common treatments for ischemia?

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Many people have coronary artery disease and are taking medications to alter the heart rate. Cardiology tests on stable patients may detect heart attack or other heart disease. Physicians recommend a low-fat diet when considering low-cholesterol diets or fibrates. Medications that control the blood pressure may be used to prevent and treat heart disease. Patients with high cholesterol may need medications to lower the blood cholesterol.

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What is ischemia?

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Ischemia is not a common complication of dental anesthesia. It is estimated to be about 7% with dental surgery and 1.5% with endodontic surgery. Dental surgery without anesthesia carries a higher risk of ischemia than dental anesthesia with no regional anesthesia.

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Can ischemia be cured?

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Ischemia (euglycemic hyperinsulinemia) does not promote angiogenesis, and is not a therapeutic target. Thus, therapies such as hyperbaric oxygen may help people who have no symptoms for years.

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What is the latest research for ischemia?

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According to [Power (ischemic-conditioned cardiomyopathy)], the most recent research findings include [improved heart conditioning in mice with heart failure by the use of [cyclic GMP analogs] and [mPTP opening as a therapy in heart disease. You can visit Power (ischemic-conditioned cardiomyopathy) for clinical trials, which includes trials in the US and Canada. power also has clinical trials in Europe and Australia. power also keeps clinical trial updates in the UK. you can [power (UK Clinical Trials Gateway) (https://www.trialregister.ac.

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What are the latest developments in tirofiban hydrochloride for therapeutic use?

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This is the first comprehensive discussion of recent developments in the development of tirofiban hydrochloride in therapeutic usage. The drug market for tirofiban hydrochloride, marketed as renoStat, has expanded rapidly since its introduction on the market in 2005. A large number of studies have been registered in several countries.

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Does tirofiban hydrochloride improve quality of life for those with ischemia?

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In a recent study, findings demonstrated for the first time that tirofiban had the potential to improve QOL of patients with moderate to severe angina symptoms.

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How does tirofiban hydrochloride work?

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The study results indicate that the use of tirofiban in patients undergoing off-pump coronary artery surgery should be continued if it decreases the risk of myocardial infarction.

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What is the primary cause of ischemia?

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Recent findings of this study provide a new insight into the pathogenesis of post-heart attack IHD. More importantly, our findings will help physicians with the diagnosis and treatment of the patients admitted for IHD.

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Has tirofiban hydrochloride proven to be more effective than a placebo?

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Tirofiban hydrochloride does not represent a good alternative in patients with the indication of an acute MI in whom thrombus is detected by CT, or in patients with a moderate to severe unstable angina pectoris who receive aspirin alone or in combination with thrombolytic therapy.

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