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Small Molecule

Sequence 1 for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Bristol-Myers Squibb
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from day 1 up to day 35±2 of each period
Awards & highlights

Study Summary

This trial is testing how a new drug affects the body in healthy people.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from day 1 up to day 35±2 of each period
This trial's timeline: 3 weeks for screening, Varies for treatment, and from day 1 up to day 35±2 of each period for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Area Under the Serum Concentration-time Curve from Time Zero Extrapolated to Infinite Time [AUC(INF)]
Area Under the Serum Concentration-time Curve from Time Zero to Time of Last Quantifiable Concentration [AUC(0-T)]
Maximum Observed Serum Concentration (Cmax)
Secondary outcome measures
Area Under the Serum Concentration-time Curve from Time 0 to 72 Hours [AUC(0-72)]
Number of Participants with Adverse Events (AEs)
Number of Participants with Clinical Laboratory Evaluation Abnormalities
+6 more

Trial Design

6Treatment groups
Experimental Treatment
Group I: Sequence 6Experimental Treatment3 Interventions
Group II: Sequence 5Experimental Treatment3 Interventions
Group III: Sequence 4Experimental Treatment3 Interventions
Group IV: Sequence 3Experimental Treatment3 Interventions
Group V: Sequence 2Experimental Treatment3 Interventions
Group VI: Sequence 1Experimental Treatment3 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mavacamten Capsule 2
2023
Completed Phase 1
~100
Mavacamten Capsule 3
2023
Completed Phase 1
~100
Mavacamten Capsule 1
2023
Completed Phase 1
~100

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Bristol-Myers SquibbLead Sponsor
2,638 Previous Clinical Trials
4,128,419 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment actively seeking out individuals aged 55 and above?

"This trial has an age requirement of 18 to 60 years old, in line with the specified inclusion criteria."

Answered by AI

Is Sequence 1 deemed a secure treatment option for patients?

"Due to its Phase 1 status, there is only minimal data indicating the safety and effectiveness of Sequence 1; as such, our team at Power has assigned it a score of 1."

Answered by AI

Is this research endeavor accepting additional participants?

"Evidenced on clinicaltrials.gov, this research is no longer sourcing participants as the study was last updated December 13th 2022 and first posted May 5th 2023. However, 847 other trials are recruiting patients currently."

Answered by AI

Can I participate in this medical research project?

"This clinical trial is on the lookout for 96 volunteers aged between 18 and 60 who are in good health. Eligible participants must have a BMI of no more than 32 kg/m^2, be deemed healthy by physical examination, ECG results and lab tests; feature normal CYP 2C19 genes as identified via genotyping before enrolment;"

Answered by AI

Who else is applying?

What state do they live in?
Florida
Kansas
What site did they apply to?
Quotient Sciences
QPS Springfield
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0
Recent research and studies
clinicaltrials.govStudy
A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants
2023. "A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05658146.
All > Montreal
~42 spots leftby Apr 2025
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