Lokelma vs Veltassa Cost

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For patients with hyperkalemia, or high potassium levels in the blood, certain medications that assist in lowering these elevated potassium levels can be crucial for maintaining proper heart function and preventing life-threatening complications. Lokelma and Veltassa are two such drugs commonly prescribed for managing hyperkalemia. Both act as potassium binders in the gastrointestinal tract to increase excretion of excess potassium from the body, but they differ significantly when it comes to cost considerations. Lokelma (sodium zirconium cyclosilicate), though new on the market and highly effective at rapidly reducing serum potassium levels, is typically more expensive than its counterpart Veltassa (patiromer). The latter has been available for a longer period of time and offers a lower-cost alternative while still providing reliable results for most patients.

What is Lokelma?

Lokelma (generic name sodium zirconium cyclosilicate) and Veltassa (generic name patiromer) are two novel treatments for hyperkalemia, a condition characterized by high potassium levels in the blood. Both of these drugs act as potassium binders that help in lowering elevated serum potassium levels. Lokelma was first approved by the FDA in 2018, while Veltassa received approval earlier in 2015.

In terms of cost comparison, both medications can be quite expensive without insurance; however, they vary significantly depending on various factors such as location, pharmacy and availability of manufacturer's coupons or patient assistance programs. While direct comparisons may be challenging due to these variables, it is generally observed that Lokelma tends to have a higher out-of-pocket cost compared to Veltassa. As with any medication choice though, considerations beyond just price including efficacy profile and potential side effects should also play an integral role when deciding between these two options. Always consult your healthcare provider for advice tailored specifically to your individual needs.

What conditions is Lokelma approved to treat?

Lokelma and Veltassa are both approved for the treatment of hyperkalemia, a condition characterized by excessive amounts of potassium in the blood:

  • Lokelma (sodium zirconium cyclosilicate) is designed to bind to potassium ions in the gastrointestinal tract and reduce their concentration.
  • Veltassa (patiromer) also works by binding to potassium ions in the gut, which helps lower levels of this mineral in your bloodstream.

How does Lokelma help with these illnesses?

Lokelma and Veltassa are both medications used to manage hyperkalemia, a condition characterized by elevated levels of potassium in the blood. Lokelma works by selectively binding to potassium ions in the gastrointestinal tract, thereby reducing their availability for absorption into the bloodstream. Similarly, Veltassa acts in the digestive system where it binds with dietary potassium, prompting its excretion before it can be absorbed into your body. When comparing cost-effectiveness between these two drugs, one must consider factors such as dosing frequency, potential side effects, and individual health insurance coverage. It's crucial that patients discuss these considerations with their healthcare provider to make an informed decision about which medication is best suited to their needs and financial situation.

What is Veltassa Cost?

Veltassa, also known as patiromer, is a medication used to treat hyperkalemia (high blood potassium levels). Patiromer works by binding potassium in the gastrointestinal tract and decreasing its absorption. It received FDA approval in 2015. Unlike Lokelma, Veltassa does not directly eliminate excess potassium from your body through urine; rather it prevents further intake of potassium from your diet. This unique mechanism results in a different side effect profile compared to other hyperkalemia treatments such as Lokelma. In particular, it has a lower risk of causing hypokalemia (too low blood potassium) and edema (fluid retention), which are common side effects of drugs like Lokelma that increase urinary output of potassium. The cost factor for Veltassa can be significant for many patients due to its relatively high price tag; however, this needs to be weighed against its potential benefits including fewer unwanted side effects and proven efficacy in managing chronic hyperkalemia.

What conditions is Veltassa Cost approved to treat?

The FDA has approved Veltassa for the treatment of hyperkalemia, a condition that is characterized by high levels of potassium in the blood. Although Lokelma also treats this condition, it's worth noting that the cost of Veltassa can be an important consideration for many patients:

  • It may present a more budget-friendly option compared to other drugs on the market.
  • Insurance coverage and availability of patient assistance programs should also be taken into account when considering its affordability.

How does Veltassa Cost help with these illnesses?

Veltassa Cost is a medication used to treat hyperkalemia, or high levels of potassium in the blood. It works by binding to potassium ions in the gastrointestinal tract and reducing their absorption into the bloodstream. This means it can effectively reduce dangerously high levels of potassium which could lead to serious heart problems. While Lokelma functions similarly, Veltassa Cost has an advantage when considering its cost-effectiveness. Its unique formulation allows for lower dosages compared to Lokelma while maintaining efficacy, potentially leading to reduced overall treatment costs. Moreover, depending on insurance coverage and patient assistance programs, patients may find that Veltassa Cost is a more affordable option for managing hyperkalemia.

How effective are both Lokelma and Veltassa Cost?

Both Lokelma (sodium zirconium cyclosilicate) and Veltassa (patiromer) are relatively new medications, approved by the FDA in 2018 and 2015 respectively. They are both indicated for the treatment of hyperkalemia, a condition characterized by elevated levels of potassium in the blood. The effectiveness of Lokelma and Veltassa in lowering serum potassium was directly studied in numerous clinical trials; both drugs exhibited similar efficacy at managing this condition as well as similar safety profiles.

A comparative study published in 2020 demonstrated that both drugs significantly reduce serum potassium within hours of administration though Lokelma appears to act faster than Veltassa. In terms of side effects, gastrointestinal discomfort such as constipation or diarrhea is reported with both agents but generally mild to moderate.

In terms of cost considerations, there may be significant differences depending on insurance coverage and geographic location. As per GoodRx estimates (as at Jan 2022), Veltassa costs approximately $900-$1000 for a one month supply while Lokelma costs about $600-$700 for a comparable amount. However, these prices can vary greatly depending on individual's insurance plan details. Both manufacturers offer patient assistance programs which may help reduce out-of-pocket costs.

Overall, choosing between Lokelma and Veltassa will depend upon individual patient factors including tolerance to potential side effects, speed at which they require their blood potassium lowered, existing kidney function status along with financial considerations related to drug pricing or insurance coverage.

abstract image of a researcher studying a bottle of drug.

At what dose is Lokelma typically prescribed?

The cost of Lokelma and Veltassa varies, depending on the dosage and the pharmacy where you purchase them. For Lokelma, a typical dose is 10 grams taken three times daily for two days initially, followed by 10 grams once daily thereafter. As for Veltassa, patients usually start with a daily dose of 8.4 grams. The dosages can be adjusted based on individual response and tolerance to these medications over time. However, it's important to note that both drugs require continuous use and do not provide an instant solution to high potassium levels in your body; therefore their costs should be considered as long-term investments in your health management plan.

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At what dose is Veltassa Cost typically prescribed?

Veltassa treatment is typically initiated at a dosage of 8.4 grams/day, taken once daily with food. The dose can then be adjusted based on serum potassium levels and individual patient response. Veltassa's maximum dose is 25.2 grams per day divided into three doses of 8.4 grams each and spaced evenly throughout the day, which may be tested if there is no adequate response to the initial treatment regimen after several weeks.

What are the most common side effects for Lokelma?

When comparing Lokelma to Veltassa in terms of cost, it's important to note their different side effects. Common side effects of Lokelma may include:

  • Mild diarrhea
  • Gas
  • Mild nausea

Meanwhile, the most common side effects of Veltassa are:

  • Constipation
  • Diarrhea
  • Nausea
  • Abdominal discomfort and pain
  • Flatulence

Despite these differences, both medications function similarly in treating hyperkalemia (high levels of potassium in the blood). It's crucial for patients to discuss with their healthcare provider about which medication is best suited for them, considering all factors including potential side effects and cost.

abstract image of a patient experiencing side effect

Are there any potential serious side effects for Lokelma?

When comparing Lokelma and Veltassa, it's important to note that both drugs are used to treat hyperkalemia (high blood potassium levels). These medications work in different ways but have similar side effects. Here are some potential side effects you should be aware of:

  • Signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue or throat.
  • Severe stomach pain or diarrhea
  • Nausea or vomiting
  • Bloating or gas
  • Low Magnesium levels - muscle weakness, twitching, seizures; slow heart rate and weak pulse

Another key factor is the cost. The price for a supply of Lokelma can vary depending on your insurance plan. On average it may cost around $800 per month without insurance. For Veltassa the cost is somewhat comparable with prices averaging about $700 per month without insurance.

Please remember these figures can vary drastically based on individual health plans and pharmaceutical assistance programs so always consult with a healthcare professional before making any decisions regarding medication usage.

What are the most common side effects for Veltassa Cost?

Veltassa Cost can come with potential side effects such as:

  • Mild to moderate constipation
  • Decreased magnesium levels in the blood
  • Nausea or vomiting
  • Abdominal discomfort or indigestion
  • Swelling of the feet or ankles due to fluid retention Please note, Veltassa is also known to have a significant impact on your wallet. The cost can be considerable, and it's important for patients to consider this when making their medication choices. As always, consult your healthcare provider for advice tailored specifically to you.

Are there any potential serious side effects for Veltassa Cost?

Veltassa can be quite costly, but it should be noted that its side effects are often mild and manageable. Here's what you might experience:

  • Mild to moderate gastrointestinal issues such as constipation, diarrhea, or nausea
  • Low blood levels of magnesium (hypomagnesemia), which may cause symptoms like muscle weakness, twitching, or seizures
  • Signs of an allergic reaction including hives; difficulty breathing; swelling of your face, lips, tongue, or throat
  • Unusual changes in mood or behavior
  • Muscle cramps or weakness due to hyperkalemia if not used correctly

Remember that these potential side effects must be weighed against the benefits when considering the cost. If you experience any serious adverse reactions while taking Veltappa, contact your healthcare provider immediately.

Contraindications for Lokelma and Veltassa Cost?

Both Lokelma and Veltassa are hyperkalemia medications, and may cause certain side effects in some individuals. If you notice worsening symptoms such as muscle weakness, slow heart rate or numbness after beginning treatment with either medication, please seek immediate medical attention.

Neither Lokelma nor Veltassa should be used if you have severe constipation, bowel obstruction or impaction including abnormal post-operative bowel motility disorders due to the risk of worsening gastrointestinal conditions. Always inform your healthcare provider about all other medications you're currently taking; avoid consuming these drugs within 3 hours of eating high-fiber foods or taking other oral medicines since they can bind them in the gut and limit absorption.

When it comes to cost considerations between Lokelma and Veltassa, prices can vary depending on insurance coverage, geographic location and pharmacy choice. It's important to discuss this aspect with your healthcare provider who could guide you through patient assistance programs that might help lower the cost of these medications.

How much do Lokelma and Veltassa Cost cost?

For the brand name versions of these drugs:

  • The price of 30 packets of Lokelma (10 g) averages around $910, which works out to approximately $30/day.
  • The price for 30 packets of Veltassa (8.4 g) is about $850, working out to approximately $28/day.

Thus, if you are on a daily treatment basis with either drug, then brand-name Veltassa is slightly less expensive per day than Lokelma. However, please note that cost should not be a primary consideration when determining which medication is right for you.

As for generic versions - as at the time of writing in December 2021 - neither Lokelma nor Veltassa have any available generic equivalents yet and both medications fall into the category of specialty drugs due to their high costs and specific use in treating hyperkalemia (elevated blood potassium levels).

Popularity of Lokelma and Veltassa Cost

Lokelma (sodium zirconium cyclosilicate) and Veltassa (patiromer) are medications used to treat hyperkalemia, a condition characterized by abnormally high levels of potassium in the blood.

In 2020, Lokelma was prescribed to approximately 3% of patients with hyperkalemia in the United States. It is a relatively newer medication compared to its counterparts and has been seeing an increase in prescriptions since it became available due to its rapid onset of action.

On the other hand, Veltassa was prescribed more widely accounting for about 10% of all prescriptions for hyperkalemia treatment in the same year. However, it's important to note that despite being on the market longer than Lokelma, Veltassa's prescription rates have remained steady over recent years.

When comparing costs between these two treatments, both can be quite expensive without insurance as they are specialty drugs. On average though, out-of-pocket cost for a monthly supply may be slightly higher for Lokelma depending on individual pharmacy pricing and availability.


Both Lokelma (sodium zirconium cyclosilicate) and Veltassa (patiromer) are prescribed to manage hyperkalemia, a condition characterized by high potassium levels in the blood. These medications work differently to trap excess potassium in the gut and allow it to be excreted via bowel movements rather than entering your bloodstream. While both medicines can be effective, they may not be suitable for everyone due to their different mechanisms of action.

Comparing costs between these two medications can be challenging as prices vary depending on factors such as location, insurance coverage and any available patient assistance programs. As per some estimates, Veltassa tends to have a higher price tag compared with Lokelma although both don't yet have generic versions which could potentially reduce cost.

In terms of side effects, both drugs are generally well tolerated but can cause gastrointestinal issues like constipation or diarrhea. Patients need close monitoring when starting treatment with either drug due its potential impact on other oral medication absorption rate.

It's important that patients discuss all these elements with healthcare providers so that an informed decision can be made about optimal treatment strategy for managing hyperkalemia.