Treatment D for Healthy Subjects

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Research Site, Brooklyn, MDHealthy SubjectsAZD5055 film-coated tablet - Drug
Eligibility
18 - 55
All Sexes
What conditions do you have?
Select

Study Summary

This study will estimate the relative bioavailability of AZD5055 film-coated tablet as compared to AZD5055 oral suspension. The study will also assess the absolute bioavailabilty of AZD5055 and the effect of food and an acid reducing agent, rabeprazole, on the PK of AZD5055 film-coated tablets when given with food (fed state) or without food (fasted state).

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

3 Primary · 0 Secondary · Reporting Duration: Day 1-6, 8-10, 13-15, 17-19

Day 1
Area under concentration time curve from time 0 to infinity (AUCinf)
Area under the concentration time curve from time 0 to the last quantifiable concentration (AUClast)
Maximum observed concentration (Cmax)

Trial Safety

Safety Progress

1 of 3

Similar Trials

Trial Design

6 Treatment Groups

Treatment D
1 of 6
Treatment E
1 of 6
Treatment F
1 of 6
Treatment B
1 of 6
Treatment A
1 of 6
Treatment C
1 of 6

Experimental Treatment

18 Total Participants · 6 Treatment Groups

Primary Treatment: Treatment D · No Placebo Group · Phase 1

Treatment D
Drug
Experimental Group · 1 Intervention: AZD5055 film-coated tablet · Intervention Types: Drug
Treatment EExperimental Group · 2 Interventions: AZD5055 film-coated tablet, Rabeprazole, Delayed-release tablet · Intervention Types: Drug, Drug
Treatment FExperimental Group · 2 Interventions: AZD5055 film-coated tablet, Rabeprazole, Delayed-release tablet · Intervention Types: Drug, Drug
Treatment B
Drug
Experimental Group · 1 Intervention: AZD5055 oral suspension · Intervention Types: Drug
Treatment A
Drug
Experimental Group · 1 Intervention: AZD5055 solution for infusion · Intervention Types: Drug
Treatment C
Drug
Experimental Group · 1 Intervention: AZD5055 film-coated tablet · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AZD5055 film-coated tablet
2022
Completed Phase 1
~20
Rabeprazole, Delayed-release tablet
2022
Completed Phase 1
~20
AZD5055 solution for infusion
2022
Completed Phase 1
~20
AZD5055 oral suspension
2022
Completed Phase 1
~20

Trial Logistics

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: day 1-6, 8-10, 13-15, 17-19

Who is running the clinical trial?

ParexelIndustry Sponsor
281 Previous Clinical Trials
96,550 Total Patients Enrolled
AstraZenecaLead Sponsor
4,020 Previous Clinical Trials
240,381,418 Total Patients Enrolled
Ronald Goldwater, MDPrincipal InvestigatorPAREXEL Early Phase Clinical Unit Baltimore
13 Previous Clinical Trials
586 Total Patients Enrolled

Eligibility Criteria

Age 18 - 55 · All Participants · 4 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

Frequently Asked Questions

Is the age eligibility for this experiment restricted to any particular range?

"For this medical research, the age requirements are individuals between 18 and 55 years old." - Anonymous Online Contributor

Unverified Answer

Has Treatment D been formally accepted by the FDA?

"Because Treatment D is in the early stages of clinical trials, our team at Power has tentatively rated its safety a 1 out of 3. This tentative rating reflects limited data supporting both efficacy and overall safety." - Anonymous Online Contributor

Unverified Answer

Are there any available vacancies to join this research endeavor?

"Indeed, the clinicaltrials.gov database indicates that this research is actively enrolling participants at present - with a posting date of November 4th 2022 and an update on November 25th 2022. Currently, 18 individuals are sought from 1 site." - Anonymous Online Contributor

Unverified Answer

Is it feasible for me to become a participant in this investigation?

"This clinical trial requires the enrolment of 18 patients that are above legal age and within a healthy range. Those who meet these criteria may qualify for participation in this study." - Anonymous Online Contributor

Unverified Answer

How many participants are being examined for this experiment?

"That is correct. Clinicaltrials.gov shows that this medical research project, which was initially posted on November 4th 2022, is presently recruiting individuals to participate in the trial. A total of 18 patients are required for enrollment at one single site." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.