Study Summary
This trial is testing whether adding immunotherapy to radiotherapy and temozolomide helps children with DIPG.
- Brain Stem Glioma
- Diffuse Intrinsic Pontine Glioma
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
2 Primary · 3 Secondary · Reporting Duration: Up to 5 years
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
2 Treatment Groups
Group A
1 of 2
Group B
1 of 2
Experimental Treatment
21 Total Participants · 2 Treatment Groups
Primary Treatment: Td vaccine · No Placebo Group · Phase 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 3 - 30 · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Who is qualified to partake in the trial?
"21 individuals with brain stem gliomas aged 3 to 30 are welcomed as part of this trial. Critically, potential participants must consent to a biopsy for diagnostic purposes and RNA extraction, maintain platelets above 100K/µl (unsupported), and have an ANC ≥ 1000/µl (unsupported). Furthermore, KPS or LPS must be > 50% within two weeks prior to enrollment." - Anonymous Online Contributor
Is elderly eligibility being considered for this medical experiment?
"This trial is inviting applicants between the ages of 3 and 30 to join." - Anonymous Online Contributor
What endemic or epidemic diseases is the Td vaccine commonly employed against?
"Td vaccine is the standard treatment for multiple sclerosis and has shown to be efficacious at treating additional medical conditions like mixed-cell type lymphoma, myelocytic leukemia, acute forms of leukemia, as well as retinoblastoma." - Anonymous Online Contributor
How many individuals are currently enrolled in this trial?
"Affirmative. The information hosted on clinicaltrials.gov confirms that this research project, which was originally published on May 17th 2018, is presently searching for willing participants. 21 individuals must be enrolled from one medical facility." - Anonymous Online Contributor
Are there current opportunities for patients to participate in this clinical investigation?
"According to clinicaltrials.gov, this drug trial is actively seeking patients. The initial post was on 17th May 2018 with the most recent update being 22nd August 2022." - Anonymous Online Contributor
Are there any other existing studies that focus on the efficacy of Td vaccine?
"Presently, there is a massive body of clinical trials researching the Td vaccine. Of these 889 active studies, 161 have progressed to Phase 3. While several are based in Philadelphia, Pennsylvania; across 28443 locations worldwide scientists and clinicians study this potential treatment." - Anonymous Online Contributor
Has the Td vaccine been authorized by the FDA?
"This vaccine has yet to be fully evaluated, so it was given a score of 1 in terms of safety. This is because this particular trial is only at the initial stages, where there exist limited data on its efficacy and safety." - Anonymous Online Contributor