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Hydrocortisone for HIV (Human Immunodeficiency Virus) (MsSCORE Trial)

Phase < 1
Waitlist Available
Led By Leah Rubin
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Above-average self-reported levels of perceived stress (>14 on the perceived stress scale (PSS-10)) and/or current SCID-V diagnosis of mood and/or anxiety disorder
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up change between baseline and 28 days
Awards & highlights

MsSCORE Trial Summary

This trial will study a new intervention for cognitive impairment in HIV-infected women, which targets the mechanisms by which stress negatively affects cognitive functioning.

MsSCORE Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
You have high levels of stress or have been diagnosed with a mood or anxiety disorder.

MsSCORE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change between baseline and 28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and change between baseline and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hopkins Verbal Learning Test-Revised assesses total learning
Hopkins Verbal Learning Test-Revised assesses verbal memory
Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Line Orientation Task assesses visuospatial abilities
+1 more
Secondary outcome measures
Comalli Stroop Test, Trial 1 assesses processing speed/attention
Comalli Stroop Test, Trial 2 assesses processing speed/attention
Comalli Stroop Test, Trial 3 assesses behavioral inhibition
+8 more

MsSCORE Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: HydrocortisoneExperimental Treatment1 Intervention
Low dose hydrocortisone (10mg orally)
Group II: PlaceboPlacebo Group1 Intervention
Placebo tablets, made of starch 1500 powder
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 4

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor
2,246 Previous Clinical Trials
14,816,634 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,778 Previous Clinical Trials
2,674,371 Total Patients Enrolled
Leah RubinPrincipal InvestigatorJohns Hopkins University

Media Library

Hydrocortisone (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT03237689 — Phase < 1
HIV (Human Immunodeficiency Virus) Research Study Groups: Hydrocortisone, Placebo
HIV (Human Immunodeficiency Virus) Clinical Trial 2023: Hydrocortisone Highlights & Side Effects. Trial Name: NCT03237689 — Phase < 1
Hydrocortisone (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03237689 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical afflictions are commonly treated with Hydrocortisone?

"Hydrocortisone is the go-to treatment for ulcerative colitis, yet it has also been used to treat a variety of other illnesses such as malignant neoplasms, varicella-zoster virus acute retinal necrosis and crohn disease."

Answered by AI

Are there other precedents for utilizing Hydrocortisone in medical trials?

"Presently, 60 clinical trials involving hydrocortisone are actively being conducted with 20 of them in their third stage. While New york City has a large number of research centers running these studies, there exist 3054 other locations worldwide participating in the examination of this drug's efficacy."

Answered by AI

To whom does this research trial extend?

"To meet the criteria for enrolment, potential participants must have HIV/AIDS and be between 18 to 65 years old. The study is aiming to recruit a total of 148 people."

Answered by AI

What are the principal aims of this experiment?

"The primary evaluation parameter for this trial is the Hopkins Verbal Learning Test-Revised, which will be conducted at baseline and again 28 days later. Secondary metrics include Trail Making Test Part B to measure cognitive agility, AST levels to assess liver function, and alkaline phosphatase readings as a further liver assessment tool. All scores are normed against population averages in order to determine clinical significance."

Answered by AI

Is the age criterion for this trial limited to those 25 years of age or older?

"The age criterion for this research is any individual older than 18 and younger than 65 years of age."

Answered by AI

How many individuals have enrolled in this research project?

"Affirmative. Clinical trials hosted on clinicaltrials.gov affirm that this medical examination, which was introduced on November 20th 2017, is actively recruiting individuals. Approximately 148 participants need to be enrolled from 1 site."

Answered by AI

Is there still room for participants in this trial?

"Confirmatively, data hosted on clinicaltrials.gov indicates that this medical study is actively recruiting participants. It was first posted to the database on November 20th 2017 and recently updated June 2nd 2022. They are looking for 148 patients from one centre."

Answered by AI
~19 spots leftby Apr 2025