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Hydrocortisone for HIV (Human Immunodeficiency Virus) (MsSCORE Trial)
MsSCORE Trial Summary
This trial will study a new intervention for cognitive impairment in HIV-infected women, which targets the mechanisms by which stress negatively affects cognitive functioning.
MsSCORE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.MsSCORE Trial Design
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Who is running the clinical trial?
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- You have had a serious head injury where you were unconscious for more than 1 hour.You have had a problem with drugs or alcohol in the past six months.You have high levels of stress or have been diagnosed with a mood or anxiety disorder.You are currently taking steroids on a regular basis.You have high blood pressure or diabetes that is not being treated right now.You have a history of dementia, any other neurological disorder affecting the brain and nervous system, or a disorder related to AIDS.You have a history of schizophrenia or a condition called schizoaffective disorder.
- Group 1: Hydrocortisone
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What medical afflictions are commonly treated with Hydrocortisone?
"Hydrocortisone is the go-to treatment for ulcerative colitis, yet it has also been used to treat a variety of other illnesses such as malignant neoplasms, varicella-zoster virus acute retinal necrosis and crohn disease."
Are there other precedents for utilizing Hydrocortisone in medical trials?
"Presently, 60 clinical trials involving hydrocortisone are actively being conducted with 20 of them in their third stage. While New york City has a large number of research centers running these studies, there exist 3054 other locations worldwide participating in the examination of this drug's efficacy."
What are the principal aims of this experiment?
"The primary evaluation parameter for this trial is the Hopkins Verbal Learning Test-Revised, which will be conducted at baseline and again 28 days later. Secondary metrics include Trail Making Test Part B to measure cognitive agility, AST levels to assess liver function, and alkaline phosphatase readings as a further liver assessment tool. All scores are normed against population averages in order to determine clinical significance."
Is the age criterion for this trial limited to those 25 years of age or older?
"The age criterion for this research is any individual older than 18 and younger than 65 years of age."
How many individuals have enrolled in this research project?
"Affirmative. Clinical trials hosted on clinicaltrials.gov affirm that this medical examination, which was introduced on November 20th 2017, is actively recruiting individuals. Approximately 148 participants need to be enrolled from 1 site."
Is there still room for participants in this trial?
"Confirmatively, data hosted on clinicaltrials.gov indicates that this medical study is actively recruiting participants. It was first posted to the database on November 20th 2017 and recently updated June 2nd 2022. They are looking for 148 patients from one centre."
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