Reviewed by Michael Gill, B. Sc.
1 Rabies Clinical Trials Near Me
Top Hospitals for Rabies Clinical Trials
Image of Emory Vaccine Center - The Hope Clinic in Georgia.
Emory Vaccine Center - The Hope Clinic
Decatur
1Active Trials
1All Time Trials for Rabies
2019First Rabies Trial
Top Cities for Rabies Clinical Trials
Image of Decatur in Georgia.
Decatur
1Active Trials
Emory Vaccine Center - The Hope ClinicTop Active Site
Rabies Clinical Trials by Phase of Trial
Phase 1 Rabies Clinical Trials
1Active Rabies Clinical Trials
1Number of Unique Treatments
1Number of Active Locations
Rabies Clinical Trials by Age Group
18 - 65 Rabies Clinical Trials
1Active Rabies Clinical Trials
Most Recent Rabies Clinical Trials
Clinical Trial
Began Recruiting Date
Phase
9/19/2019
Phase 1
Top Treatments for Rabies Clinical Trials
Treatment Name
Active Rabies Clinical Trials
All Time Trials for Rabies
First Recorded Rabies Trial
ChAd155-RG
1
1
2019
Recently Completed Studies with FDA Approved Treatments for Rabies
Treatment
Year
Sponsor
SYN023
2019
Synermore Biologics Co., Ltd.
Lower dose formulation of RG SAM (CNE) vaccine (GSK3903133A)
2019
GlaxoSmithKline

What Are Rabies Clinical Trials?

Rabies is a viral zoonotic disease that spreads through the bite of an infected, rabid animal. It causes brain and spinal cord swelling, eventually resulting in death. According to the CDC, the most commonly infected rabid mammals include bats, foxes, raccoons, and skunks. 

Rabies causes neurologic symptoms like hallucinations, delirium, hydrophobia, and insomnia, ultimately leading to death. The disease is always almost fatal, and CDC records less than 20 cases of human survival after contracting clinical rabies.

Given the disease's high mortality rate, rabies clinical trials assess the safety and efficacy of rabies vaccines on healthy adults. They dedicate investigative efforts to finding out the progression of the disease to allow for better patient outcomes. Rabies clinical trials can help devise new treatments to lower the fatality from this infection.

Why is Rabies Being Studied Through Clinical Trials?

Vaccines are an effective way to reduce the death rate from rabies. This is where rabies clinical trials come in handy. They test vaccines to reduce the transmission of the virus and save lives. In 2018, there were 3 cases of rabies in humans and 4951 rabies cases among animals in the U.S. These statistics represented an 11.2% increase from 2017, requiring rabies clinical trials to prevent further increase. Rabies Virus has an almost 100% mortality rate, which mandates the need for more research on this increasing yet neglected global concern.

Rabies is not only fatal but has an economic burden on the community. Rabies prevention, diagnosis, and control cost the U.S. between $245 and $510 every year. Even if not many people contract the disease, approximately 55,000 Americans get diagnostic testing, and postexposure prophylaxis (PEP) annually. Rabies clinical trials work to minimize the spread of the disease and the risk of contracting it.

What Are the Types of Treatments Available for Rabies?

Once a person is diagnosed with rabies, there is no proper treatment or cure for it. Once bitten by a rabid animal, the following rabies shots may be delivered:

  • Rabies immune globulin, a fast-acting shot that prevents the virus from infecting the affected person in the event that they have not received the rabies vaccine
  • Rabies vaccination shots (usually 4) to develop immunity against the infection

What Are Some Recent Breakthrough Clinical Trials for Rabies?

There have been several landmark studies involving rabies in recent years. Some of the most recent studies are:

2022: A new study headed by Erica Ollmann Saphir and her team in tandem with Hervé Bourhy, Ph.D., of the Institut Pasteur, explored the pathway to a better rabies vaccine design. This study explores how the neutralizing antibodies vaccine can and should target the only visible virus protein, the rabies glycoprotein (RABV-G), to fight the infection. 

2021: This breakthrough study in China explored the potential of Clofazimine (CFZ) in targeting viral membrane fusion during the onset of the disease, curbing its spread. This finding revealed the potential use of CFZ as an effective drug in treating his deadly infection.

Who Are Some Of The Key Opinion Leaders / Researchers / Institutions Conducting Rabies Clinical Trials Research?

Elsevier funds global research methods on various healthcare concerns like rabies. It offers research platforms, resources, and tools to help researchers and healthcare experts bring about improvements in their respective fields, like rabies.

The University of Glasgow is dedicated to rabies research to eliminate the disease. The experts at Glasgow have been in the process of carrying out rabies research in Tanzania for the past 20 years to find answers to the most pertinent questions that could help control this infection.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 10th, 2021

Last Reviewed: November 1st, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.