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McGuire VA Medical Center
Claim this profileBurke, Virginia 22015
Global Leader in Liver Cirrhosis
Global Leader in Fibrosis
Conducts research for Prostate Cancer
Conducts research for Non-alcoholic Fatty Liver Disease
Conducts research for Fatty Liver Disease
141 reported clinical trials
30 medical researchers
Summary
McGuire VA Medical Center is a medical facility located in Burke, Virginia. This center is recognized for care of Liver Cirrhosis, Fibrosis, Prostate Cancer, Non-alcoholic Fatty Liver Disease, Fatty Liver Disease and other specialties. McGuire VA Medical Center is involved with conducting 141 clinical trials across 248 conditions. There are 30 research doctors associated with this hospital, such as Jasmohan Bajaj, MD, Lance Goetz, MD, Denise Lester, MD, and Howard Li.Top PIs
Jasmohan Bajaj, MDHunter Holmes McGuire VA Medical Center1 year of reported clinical research
Studies Liver Cirrhosis
Studies Fibrosis
7 reported clinical trials
8 drugs studied
Lance Goetz, MDHunter Holmes McGuire VA Medical Center2 years of reported clinical research
Studies Spinal Cord Injury
Studies Wounds and Injuries
3 reported clinical trials
6 drugs studied
Denise Lester, MDHunter Holmes McGuire Veterans Affairs Medical Center4 years of reported clinical research
Studies Lower Back Pain
Studies Back Pain
2 reported clinical trials
4 drugs studied
Howard LiHunter Holmes McGuire Veterans Administration Medical Center3 years of reported clinical research
Studies Lung Cancer
Studies Non-Small Cell Lung Cancer
2 reported clinical trials
2 drugs studied
Clinical Trials running at McGuire VA Medical Center
Liver Cirrhosis
Prostate Cancer
Lung Cancer
Spinal Cord Injury
Fibrosis
Liver Failure
Heart Failure
Non-Small Cell Lung Cancer
Crohn's Disease
Parkinson's Disease
Resmetirom
for NASH Cirrhosis
This study will determine the effect of oral 80 mg resmetirom administered once daily on participants with well-compensated non-alcoholic steatohepatitis (NASH) cirrhosis by measuring the time to experiencing a Composite Clinical Outcome event.
Recruiting1 award Phase 39 criteria
Prebiotics
for PTSD and Liver Cirrhosis
Despite medical advancements, PTSD remains a major issue in Veterans1. Current treatment strategies have relatively poor adherence. In patients with PTSD and cirrhosis, there is greater cognitive impairment as well as changes in gut microbiome structure and function2,3. In addition, when there is concomitant cirrhosis, medication-related treatment options become even narrower from a safety and tolerability perspective and cognitive issues pertaining to cirrhosis could impact participation3. Changes in gut microbiome in Veterans with cirrhosis and PTSD compared to those with cirrhosis without PTSD is characterized by a greater relative expression of pathobionts and reduction in stool microbiome diversity with reduction in bacteria that produce beneficial short chain fatty acids (SCFA)2. Modulation of the gut microbiome in patients with cirrhosis and PTSD may be an important therapeutic target. In prior studies with cirrhosis alone, microbial modulation using diet, antibiotics such as rifaximin, probiotics, and fecal microbiota transplant have improved gut microbial diversity and clinical outcomes in some cases4,5. In patients with cirrhosis without PTSD and in patients with PTSD without cirrhosis there is emerging evidence regarding prebiotics and other forms of gut microbial modulation. Prebiotics are such an example6. Prebiotics are natural fibers derived from carbohydrates and can be beneficial to gut microbiota (good bacteria in the gut)6. Resistant starches (RS) are dietary fiber prebiotics found naturally in many foods including potatoes, plantains, and legumes6,7. In addition to being highly accessible, RS have been shown to be well tolerated with few adverse reactions. While no studies of RS exist in PTSD + cirrhosis patients, a meta-analysis of RS in IBD has shown RS to be an effective treatment in both animal and clinical studies where improvements in clinical remission and reduced mucosal damage were found7. However, there is insufficient data regarding patients with PTSD and cirrhosis regarding gut microbial structure and function modulation with dietary supplements such as resistant starches. These starches can improve SCFA production in elderly subjects, which could in turn affect the gut-brain axis favorably8.
Recruiting1 award N/A3 criteria
Sensor Skin
for Liver Cirrhosis
Longitudinal monitoring of inflammation using skin devices may help predict outcomes compared to traditional blood draws
Recruiting1 award N/A8 criteria
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Frequently asked questions
What kind of research happens at McGuire VA Medical Center?
McGuire VA Medical Center is a medical facility located in Burke, Virginia. This center is recognized for care of Liver Cirrhosis, Fibrosis, Prostate Cancer, Non-alcoholic Fatty Liver Disease, Fatty Liver Disease and other specialties. McGuire VA Medical Center is involved with conducting 141 clinical trials across 248 conditions. There are 30 research doctors associated with this hospital, such as Jasmohan Bajaj, MD, Lance Goetz, MD, Denise Lester, MD, and Howard Li.