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Uricosuric Agent

Probenecid for Heart Failure (Re-Prosper HF Trial)

Q: What medical conditions is Probenecid most often used to treat?

<p>Probenecid is often used to manage gouty <a href="https://www.withpower.com/clinical-trials/arthritis">arthritis</a>, but can also help patients that suffer from other conditions like chronic <a href="https://www.withpower.com/clinical-trials/gout">gout</a>, hyperuricemia, and regular arthritis.</p>

Phase 2 & 3

Recruiting

Led By Jack Rubinstein, MD

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 years or older

NYHA class II-III

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

Re-Prosper HF Trial Summary

This trial will test whether a drug used to treat gout can also be used to improve heart function in veterans with HFrEF.

Who is the study for?

This trial is for Veterans aged 18+ with heart failure (HFrEF) who've been stable on standard treatments for at least two weeks. They must have a left ventricular ejection fraction of ≤40% documented in the past year. Exclusions include recent acute coronary events, severe kidney disease, certain heart procedures or conditions within specific timeframes, pregnancy, and known allergies to probenecid.Check my eligibility

What is being tested?

The study tests if probenecid, typically used for gout, can improve heart function in those with HFrEF when taken twice daily over six months. It will be compared against a placebo. Heart function will be measured by ultrasound; exercise capacity and health status through questionnaires are also evaluated.See study design

What are the potential side effects?

While not specified here, common side effects of probenecid may include allergic reactions, gastrointestinal discomforts like nausea or vomiting, dizziness, headaches and possible worsening of gout symptoms initially.

Re-Prosper HF Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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My heart condition limits my physical activity but I can still perform light tasks.

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I have been diagnosed and treated for heart failure.

Re-Prosper HF Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change from baseline in cardiac function

Secondary outcome measures

Change from baseline in The Kansas City Cardiomyopathy Questionnaire (KCCQ) and EQ5D

Change from baseline in exercise tolerance via a symptom-limited exercise test on a cycle ergometer

Re-Prosper HF Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: ProbenecidActive Control1 Intervention

1 gr. orally of probenecid twice daily for 180 days

Group II: PlaceboPlacebo Group1 Intervention

identical placebo (to probenecid tablets) for 180 days

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor

1,611 Previous Clinical Trials

3,305,164 Total Patients Enrolled

38 Trials studying Heart Failure

63,068 Patients Enrolled for Heart Failure

Jack Rubinstein, MDPrincipal InvestigatorCincinnati VA Medical Center, Cincinnati, OH

1 Previous Clinical Trials

2 Total Patients Enrolled

Media Library

probenecid (Uricosuric Agent) Clinical Trial Eligibility Overview. Trial Name: NCT04551222 — Phase 2 & 3

Heart Failure Research Study Groups: Probenecid, Placebo

Heart Failure Clinical Trial 2023: probenecid Highlights & Side Effects. Trial Name: NCT04551222 — Phase 2 & 3

probenecid (Uricosuric Agent) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04551222 — Phase 2 & 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical conditions is Probenecid most often used to treat?

"Probenecid is often used to manage gouty arthritis, but can also help patients that suffer from other conditions like chronic gout, hyperuricemia, and regular arthritis."

Answered by AI

Are there currently any patients being recruited for this clinical trial?

"Yes, this is an ongoing study that has been updated as recently as 9/14/2022. The research began on 6/9/2021 and they are looking for 120 participants who will be spread out over 3 locations."

Answered by AI

What is the scholarly research on Probenecid's efficacy?

"As of now, there are 3 Probenecid clinical trials underway. 2 of these active trials are in their third phase. Although a majority of the related studies take place in Providence, Rhode island, there are 4 locations total running these investigations."

Answered by AI

How many volunteers are enrolled in this experiment?

"One hundred and twenty volunteers that fit the required profile are needed for this experiment. The study is conducted at different sites, such as Providence VA Medical Center in Providence, RI and Cincinnati VA Medical Center in Cincinnati, OH."

Answered by AI