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Behavioural Intervention

Exercise Training for Insulin Resistance

N/A
Waitlist Available
Led By Jill Kanaley
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Sedentary (not engaged in planned physical activities and performing less than a total of 2 h of physical activity per week during the last 6 months) men and women whose BMI is classified as obese (>30 kg/m2)
Be between 18 and 65 years old
Must not have
Uncontrolled hypertension (no beta blockers)
On any medications known to impact metabolism
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks
Awards & highlights

Summary

This trial will examine how exercise training affects glucose uptake into fat tissue in obese people, and if there are sex differences. #exercise #obesity #glucose #insulin #insulinresistance

Who is the study for?
This trial is for non-smoking, sedentary men and women who are obese (BMI >30 kg/m2) and have been weight stable in the past 6 months. They should not be on medications affecting metabolism or have cardiovascular disease, uncontrolled hypertension, orthopedic limitations, recent hormonal birth control changes, or pregnancy.Check my eligibility
What is being tested?
The study investigates how a 4-week exercise program affects fat tissue's ability to take up glucose in obese individuals. It aims to understand if regular physical activity can improve insulin sensitivity and overall metabolic health by focusing on changes in adipose tissue.See study design
What are the potential side effects?
Since the intervention involves exercise training, potential side effects may include muscle soreness, fatigue, joint pain or discomfort during the initial period of increased physical activity.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am not very active and my BMI is over 30.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My high blood pressure is not managed without beta blockers.
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I am taking medication that affects my metabolism.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
GLUT4 protein expression
TB1CD4 protein expression
Secondary outcome measures
percent body fat

Trial Design

1Treatment groups
Experimental Treatment
Group I: ExerciseExperimental Treatment1 Intervention
All subjects will undergo exercise training for 4 wks. 45-60 min of exercise, 4 sessions/wk supervised, 1 session unsupervised. intensity 60% of VO2 max
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
exercise
2014
Completed Phase 4
~1190

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
367 Previous Clinical Trials
628,393 Total Patients Enrolled
20 Trials studying Obesity
2,178 Patients Enrolled for Obesity
Jill KanaleyPrincipal InvestigatorUniversity of Missouri-Columbia

Media Library

Exercise Training (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05930834 — N/A
Obesity Research Study Groups: Exercise
Obesity Clinical Trial 2023: Exercise Training Highlights & Side Effects. Trial Name: NCT05930834 — N/A
Exercise Training (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05930834 — N/A
~16 spots leftby Oct 2025
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