day 5 uterine transfer for Infertility
Phase-Based Progress Estimates
Effectiveness
Safety
Infertility
day 5 uterine transfer - ProcedureEligibility
18 - 65
Female
What conditions do you have?
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Eligibility
18 - 65
Female
What conditions do you have?
Select
Study Summary
This trial is testing whether it's better to transfer embryos on day 3 or day 5 of IVF in patients with 5 or fewer embryos. The goal is to find the best way to maximize the chances of success for these patients.
Treatment Effectiveness
Effectiveness Progress
Other trials for Infertility
Study Objectives
1 Primary · 4 Secondary · Reporting Duration: 2 years
14 days
Clinical pregnancy
2 years
Time to pregnancy/live birth
9 months
Multiple pregnancy
Ongoing pregnancy
live birth
Trial Safety
Safety Progress
Other trials for Infertility
Trial Design
2 Treatment Groups
day 5 embryo transfer
1 of 2
day 3 embryo transfer
1 of 2
Experimental Treatment
658 Total Participants · 2 Treatment Groups
Primary Treatment: day 5 uterine transfer · No Placebo Group · N/A
day 5 embryo transfer
Procedure
Experimental Group · 1 Intervention: day 5 uterine transfer · Intervention Types: Procedureday 3 embryo transfer
Procedure
Experimental Group · 1 Intervention: day 3 uterine transfer · Intervention Types: ProcedureTrial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years
Who is running the clinical trial?
Boston IVFOTHER
17 Previous Clinical Trials
18,974 Total Patients Enrolled
16 Trials studying Infertility
18,674 Patients Enrolled for Infertility
Beth Israel Deaconess Medical CenterLead Sponsor
772 Previous Clinical Trials
847,895 Total Patients Enrolled
Werner Neuhausser, MD PhDPrincipal Investigator - Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
Eligibility Criteria
Age 18 - 65 · Female Participants · 2 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You have given your written, informed consent to participate in this study.
You have undergone an autologous IVF cycle.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
Who else is applying?
What state do they live in?
| Texas | 14.3% |
| Ohio | 14.3% |
| Florida | 10.7% |
| Other | 60.7% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Boston IVF | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 100.0% |
References
- Marek, Del, Martin Langley, David K Gardner, Nils Confer, Kathleen M Doody, and Kevin J Doody. 1999. “Introduction of Blastocyst Culture and Transfer for All Patients in an in Vitro Fertilization Program”. Fertility and Sterility. Elsevier BV. doi:10.1016/s0015-0282(99)00409-4.
- Glujovsky D, Farquhar C, Quinteiro Retamar AM, Alvarez Sedo CR, Blake D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016 Jun 30;(6):CD002118. doi: 10.1002/14651858.CD002118.pub5. Review.
- Tsirigotis, M.. 1998. “Blastocyst Stage Transfer: Pitfalls and Benefits. Too Soon to Abandon Current Practice?”. Human Reproduction. Oxford University Press (OUP). doi:10.1093/humrep/13.12.3285.
- Neuhausser, Werner M., Denis A. Vaughan, Denny Sakkas, Michele R. Hacker, Tom Toth, and Alan Penzias. 2020. “Non-inferiority of Cleavage-stage Versus Blastocyst-stage Embryo Transfer in Poor Prognosis IVF Patients (precise Trial): Study Protocol for a Randomized Controlled Trial”. Reproductive Health. Springer Science and Business Media LLC. doi:10.1186/s12978-020-0870-y.
- “Blastocyst Culture and Transfer in Clinical-assisted Reproduction: A Committee Opinion”. 2013. “Blastocyst Culture and Transfer in Clinical-assisted Reproduction: A Committee Opinion”. Fertility and Sterility. Elsevier BV. doi:10.1016/j.fertnstert.2013.01.087.
- Gardner, D. K., W. B. Schoolcraft, L. Wagley, T. Schlenker, J. Stevens, and J. Hesla. 1998. “A Prospective Randomized Trial of Blastocyst Culture and Transfer in In- Vitro Fertilization”. Human Reproduction. Oxford University Press (OUP). doi:10.1093/humrep/13.12.3434.
- Papanikolaou, E. G.. 2005. “Live Birth Rate Is Significantly Higher After Blastocyst Transfer Than After Cleavage-stage Embryo Transfer When at Least Four Embryos Are Available on Day 3 of Embryo Culture. A Randomized Prospective Study”. Human Reproduction. Oxford University Press (OUP). doi:10.1093/humrep/dei217.
- Papanikolaou, Evangelos G., Michel Camus, Efstratios M. Kolibianakis, Lisbet Van Landuyt, Andre Van Steirteghem, and Paul Devroey. 2006. “In Vitro Fertilization with Single Blastocyst-stage Versus Single Cleavage-stage Embryos”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejmoa053524.
- Glujovsky D, Farquhar C, Quinteiro Retamar AM, Alvarez Sedo CR, Blake D. Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology. Cochrane Database Syst Rev. 2016 Jun 30;(6):CD002118. doi: 10.1002/14651858.CD002118.pub5. Review. Update in: Cochrane Database Syst Rev. 2022 May 19;5:CD002118.
- Werner Neuhausser 2021. "PooR Embryo Yield Cleavage Stage Versus blaStocyst Embryo Transfer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03764865.
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