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LYR-220 Design 2 for Chronic Sinusitis

Phase 2
Waitlist Available
Research Sponsored by Lyra Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through week 28
Awards & highlights

Summary

This trial will study two different designs of the drug LYR-220 in people with CRS who have had sinus surgery. They will look at how safe and tolerated the drug is, how it is absorbed and metabolized, and how effective it is.

Eligible Conditions
  • Chronic Sinusitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through week 28
This trial's timeline: 3 weeks for screening, Varies for treatment, and through week 28 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Plasma MF concentrations
Product-related unexpected serious adverse events
Secondary outcome measures
Adverse Events
Change in Chronic Rhinosinusitis (CRS) symptom scores
Endoscopic findings
+4 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment Arm B: LYR-220 Design 2Experimental Treatment1 Intervention
Bilateral insertion of LYR-220 drug matrix (mometasone furoate 7500 µg) Design 2
Group II: Treatment Arm A: LYR-220 Design 1Experimental Treatment1 Intervention
Bilateral insertion of LYR-220 drug matrix (mometasone furoate 7500 µg) Design 1
Group III: Treatment Arm C: Bilateral sham procedure controlPlacebo Group1 Intervention
Bilateral sham procedure control
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LYR-220 Design 2
2021
Completed Phase 2
~50
LYR-220 Design 1
2021
Completed Phase 2
~50

Find a Location

Who is running the clinical trial?

Lyra TherapeuticsLead Sponsor
4 Previous Clinical Trials
467 Total Patients Enrolled
4 Trials studying Chronic Sinusitis
467 Patients Enrolled for Chronic Sinusitis
~14 spots leftby Jul 2025