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LYR-220 Design 2 for Chronic Sinusitis

Phase 2
Waitlist Available
Research Sponsored by Lyra Therapeutics
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through week 28
Awards & highlights

Study Summary

This trial will study two different designs of the drug LYR-220 in people with CRS who have had sinus surgery. They will look at how safe and tolerated the drug is, how it is absorbed and metabolized, and how effective it is.

Eligible Conditions
  • Chronic Sinusitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through week 28
This trial's timeline: 3 weeks for screening, Varies for treatment, and through week 28 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Plasma MF concentrations
Product-related unexpected serious adverse events
Secondary outcome measures
Adverse Events
Change in Chronic Rhinosinusitis (CRS) symptom scores
Endoscopic findings
+4 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Treatment Arm B: LYR-220 Design 2Experimental Treatment1 Intervention
Bilateral insertion of LYR-220 drug matrix (mometasone furoate 7500 µg) Design 2
Group II: Treatment Arm A: LYR-220 Design 1Experimental Treatment1 Intervention
Bilateral insertion of LYR-220 drug matrix (mometasone furoate 7500 µg) Design 1
Group III: Treatment Arm C: Bilateral sham procedure controlPlacebo Group1 Intervention
Bilateral sham procedure control
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
LYR-220 Design 2
2021
Completed Phase 2
~50
LYR-220 Design 1
2021
Completed Phase 2
~50

Find a Location

Who is running the clinical trial?

Lyra TherapeuticsLead Sponsor
4 Previous Clinical Trials
467 Total Patients Enrolled
4 Trials studying Chronic Sinusitis
467 Patients Enrolled for Chronic Sinusitis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the scope of enrolment for this experiment?

"Indeed, clinicaltrials.gov highlights that this trial is actively searching for participants. The study was initially listed on November 23rd 2021 and has been updated on October 25th 2022. 70 individuals need to be recruited from 21 separate sites."

Answered by AI

What purpose does this experiment endeavor to accomplish?

"During the 28 week duration of this trial, Plasma MF concentrations will act as the primary measured outcome. Supplementary outcomes that are to be monitored include: Intraocular Pressure (IOP), Adverse Events and their severity, and Laboratory Values (hematology and chemistry)."

Answered by AI

Is there any potential for harm with LYR-220 Design 2?

"LYR-220 Design 2's safety has been largely supported by data from Phase 2 trials, thus receiving a score of 2 on the scale. As such, efficacy is yet to be assessed."

Answered by AI

In which locations is the team overseeing this medical experiment operating?

"Presently, the trial is being conducted in 21 different medical centres across America. These sites are based in Baltimore, Carlsbad and Spokane as well as 18 other places of residence. In order to reduce travelling costs for participants, it may be prudent to select a centre closest to your home address."

Answered by AI

Is this medical experiment in need of more participants right now?

"Indeed, according to information posted on clinicaltrials.gov, this study is actively enrolling participants. The initial posting date was November 23rd 2021 with the most recent amendment made on October 25th 2022."

Answered by AI
~15 spots leftby Apr 2025