Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests different doses of mometasone in nasal irrigation for patients with chronic sinusitis. The goal is to see if it affects cortisol levels in the body. Mometasone helps reduce nasal inflammation and is less likely to enter the bloodstream, making it safer for long-term use. Mometasone furoate has been used in various forms, such as nasal sprays and gels, to treat sinusitis and reduce nasal inflammation.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you've used systemic corticosteroids in the past month or are taking medications that affect the HPA axis (a system that controls stress response and other body processes).
Is Nasal Mometasone Rinse safe for humans?
How is nasal mometasone rinse different from other treatments for sinus conditions?
Nasal mometasone rinse is unique because it involves flushing a solution containing mometasone, a corticosteroid, through the sinonasal cavity, providing direct contact with the nasal tissues. This method may offer more targeted relief compared to standard nasal sprays, which are typically used for conditions like allergic rhinitis.35678
What data supports the effectiveness of the drug Nasal Mometasone Rinse?
Who Is on the Research Team?
Bobby Tajudeen, MD
Principal Investigator
Rush University Medical Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive nasal mometasone irrigations in varying dosages for 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Nasal Mometasone Rinse
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rush University Medical Center
Lead Sponsor
Advanced Rx
Industry Sponsor