Your session is about to expire
← Back to Search
Vaccine Therapy + GM-CSF for Leukemia
Study Summary
This trial is studying a vaccine made from a peptide as a possible treatment for acute myeloid leukemia. The vaccine is being given with colony-stimulating factors (such as GM-CSF) which increase the number of white blood cells and platelets. The trial will compare the vaccine given with GM-CSF to a placebo given with GM-CSF to see if the vaccine is more effective.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- I have not received a vaccine for acute myeloid leukemia.I do not have any lung problems causing symptoms.I do not have acute promyelocytic leukemia in its first complete remission.I have never tested positive for HIV/AIDS.My life expectancy is not majorly reduced by other illnesses.I have fully recovered from any previous surgeries or radiation treatments.I am using corticosteroids that are applied to the skin or inhaled.My AML diagnosis is new and not linked to any previous blood disorders or treatments.My AML developed from a previous blood disorder or after exposure to cancer-causing agents.My leukemia is in the first complete remission and is classified as M0-M2 or M4-M7.I am HLA-A2 positive.It's been over 3 months since I last took experimental drugs or certain immune-suppressants.I am not currently undergoing radiotherapy.I am over 55 and in my first complete remission or over 18 and in my second, within the last month.My leukemia is in the second complete remission.My cancer has not spread outside the bone marrow.I do not have active leukemia in my brain or spinal cord.I am fully active or can carry out light work.I haven't had any cancer except for skin cancer or early-stage cervical/breast cancer in the last 5 years.- You can perform daily activities without any difficulty (ECOG performance status 0-1)
- You are not expected to have a limited life expectancy due to other health conditions
- You have enough white blood cells and platelets
- Your liver and kidney function are within normal range
- You are not pregnant, breastfeeding or planning to have a baby
- You are not allergic to incomplete Freund's adjuvant
- You don't have any serious medical condition or psychiatric illness that may affect your participation in the study or increase your risk
- You don't have any other cancer except for some specific types
- You don't have any active infection or high fever
- You don't have any serious heart or lung disease
- You don't have HIV or AIDS
- You are not allergic to sargramostim (GM-CSF) or yeast-derived products
- You don't have a history of Wegener's granulomatosis or vasculitisI have not had a stem cell transplant from a donor or twin.I have not had any organ transplant surgeries.I haven't taken high-dose steroids for more than 2 weeks in the last month.I have never had Wegener's granulomatosis or vasculitis.I had fatigue, bleeding, or infections for over a month before my AML diagnosis, confirmed by blood tests.I do not have any heart-related symptoms.I haven't had a fever for 7 days without taking antibiotics.I have been diagnosed with acute myeloid leukemia.I do not have any worsening viral or bacterial infections.
- Group 1: Arm I
- Group 2: Arm II
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is this clinical trial being offered in more than one hospital?
"This trial is taking place at 15 different institutions, for example University of Chicago Cancer Research Center, Greenebaum Cancer Center at University of Maryland Medical Center, and Cancer Care Centers of South Texas - Southeast."
Are there any other ongoing research initiatives using PR1 leukemia peptide vaccine?
"There are currently 43 clinical trials studying the efficacy of PR1 leukemia peptide vaccines, 5 of which are in Phase 3. The majority of these studies are based in Seattle, but there are a total of 1885 hospitals and research centres running trials for this treatment worldwide."
Share this study with friends
Copy Link
Messenger