This trial is evaluating whether AMG 404 will improve 5 primary outcomes and 9 secondary outcomes in patients with Solid Tumors, Advanced Solid Tumors. Measurement will happen over the course of 28 Days.
This trial requires 170 total participants across 9 different treatment groups
This trial involves 9 different treatments. AMG 404 is the primary treatment being studied. Participants will be divided into 9 treatment groups. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.
"It seems many common treatments for cancer are useless. It might have been better if the trials that support the treatments were of higher quality." - Anonymous Online Contributor
"Symptoms of a malignant neoplasm may be vague and nonspecific. The most common sign of cancer is weight loss or loss of appetite. However, these two manifestations may occur in more than 90% of cases of bowel cancer. A history of cancer may increase the likelihood that a current ailment, such as gastroenteritis, will be found to be a manifestation of cancer." - Anonymous Online Contributor
"The word cancer was coined for the first time in around 1000 BC. It is also an ancient concept which has changed considerably over the last millennia. The word comes from Greek –kýmōs-, ("kingdom"), -cýma-, ("of a seed"), which comes from kýmōn, ("seed of"), and –kýma- ("birth") with the assumption of a "crush" or "foetus" (of which there is no evidence or known use to this day), and finally –kýma-, ("birth")." - Anonymous Online Contributor
"It is currently too early to be certain that cancer can be cured although it seems that some patients are responding to treatment. This is because there are some patients who may not respond to any treatment but also patients whose response to treatments may be transient. These patients are still at risk of relapse. The current challenge will be to identify these patients and to devise the best treatments or combination treatments to deal with them. However, we also need to think how and when to treat these 'transient responder' patients if we do eventually find a way to cure them. This paper highlights many questions to consider and provides some suggestions." - Anonymous Online Contributor
"Each year, around 8.8 million US adults are diagnosed with some form of cancer. This makes up 20.6% of American adults. Overall, there are about 2.8 people per 1000 persons diagnosed with cancer in the United States each year. \n" - Anonymous Online Contributor
"Many types of cancer are multifactorial and many causal pathways connect environmental and genetic factors with the underlying biological cause. It is now considered more important to understand the role of environmental factors that are modifiable, rather than the underlying biological pathways. Cancer prevention is an urgent matter that needs to be explored beyond identifying environmental factors that are amenable to intervention." - Anonymous Online Contributor
"Amg 404 was typically used in combination with any of the following chemotherapy regimens: gemcitabine, paclitaxel, docetaxel, liposomal doxorubicin, doxorubicin, vincristine, and cisplatin/paclitaxel. We do not consider the combination of Amg 404 and gemcitabine plus paclitaxel to be effective. The combination of Amg 404 with gemcitabine warrants further study. In a recent study, findings suggest that Amg 404 may be an active agent when used in a combination treatment regimen." - Anonymous Online Contributor
"In this small study there were no common or clinically meaningful differences between placebo and Amg 404 in the incidence of side effects assessed by patients or physicians. The most common treatment-emergent adverse events in patients in the placebo arm included headache, headache worsened or new, headache worsened upon standing, and fatigue. The most common treatment-emergent adverse events in physicians in the placebo arm included headache, headache worsened or new, headache worsened upon standing, and diarrhea. The most common treatment-emergent adverse events in patients treated with Amg 404 included headache, headache worsened or new, headache worsened upon standing, nausea, constipation, and fatigue." - Anonymous Online Contributor
"Based on the results to date, AMG-404 has been shown to produce durable antitumor responses at a high therapeutic dose. Although there have been ongoing Phase II clinical trials, the current clinical development plan for AMG-404 is focused on evaluating long-term efficacy in conjunction with conventional chemotherapies and radiation therapy, with the goal of developing a novel regimen for patients requiring systemic therapy." - Anonymous Online Contributor
"The incidence of cancer is not different in firstborn versus secondborn siblings in a population of 5- to 10-year-old boys, and cancer incidence as a total number of cancer cases or in specific sites is not different in firstborn versus secondborn boys. This suggests that a predominant oncogene is not involved in hereditary cancer predisposition in all children, though one or more are likely to be involved in some families." - Anonymous Online Contributor
"It was well tolerated by patients. The side effects encountered were mild in nature. Amg 404 is a newly developed drug with a potential therapeutic role in treating BRCA-affected cancers." - Anonymous Online Contributor
"The only new drug approved in the US for clinical use this year that is undergoing Phase 3-4 trials is amg 404, a therapeutic antibody. The other drugs and biologics in clinical research and development for therapeutic use have not been approved for clinical use this year. Thus, a major change has occurred not only for the future of cancer treatment, but also for clinical research and the creation of therapeutic proteins from research." - Anonymous Online Contributor