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Monoclonal Antibodies

BMS-986322 + Rosuvastatin + Metformin + Methotrexate for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Bristol-Myers Squibb
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 51 days
Awards & highlights

Summary

This trial will study how drugs interact when taken together to see if they work better than when taken alone.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 51 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 51 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Area under the plasma concentration-time curve from time zero extrapolated to infinite time (AUC[INF])
Area under the plasma concentration-time curve from time zero to time of last quantifiable concentration (AUC [0-T])
Maximum observed plasma concentration (Cmax)
Secondary outcome measures
Apparent terminal phase half-life (T-HALF)
Apparent total body clearance (CLT/F)
Number of participants with adverse events (AEs)
+5 more

Trial Design

3Treatment groups
Experimental Treatment
Group I: Part 3: Methotrexate + BMS-986322 + LeucovorinExperimental Treatment3 Interventions
Group II: Part 2: Metformin + BMS-986322 + GlucoseExperimental Treatment3 Interventions
Group III: Part 1: Rosuvastatin + BMS-986322Experimental Treatment2 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Methotrexate
2013
Completed Phase 4
~3800
Leucovorin
2005
Completed Phase 4
~5730
BMS-986322
2022
Completed Phase 1
~330
Rosuvastatin
2019
Completed Phase 4
~3150
Metformin
2006
Completed Phase 4
~2430
Glucose
2017
Completed Phase 4
~850

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Bristol-Myers SquibbLead Sponsor
2,652 Previous Clinical Trials
4,130,673 Total Patients Enrolled
~28 spots leftby Jul 2025
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