Treatment for Vocal Cord Resection

Phase-Based Estimates
1
Effectiveness
1
Safety
MUHC, Montreal, Canada
+1 More
Eligibility
18+
All Sexes
Eligible conditions
Vocal Cord Resection

Study Summary

This study is evaluating whether deep neuromuscular blockade is better than moderate neuromuscular blockade in patients undergoing vocal cord resections requiring jet ventilation.

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Eligible Conditions

  • Vocal Cord Resection
  • High Frequency Jet Ventilation

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Compared to trials

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 12 secondary outcomes in patients with Vocal Cord Resection. Measurement will happen over the course of During the stay in the recovery room, an average of 3 hours.

Hour 4
Arterial blood pressure
Body temperature
Heart rate
Occurence of nausea/vomiting
Oxygen saturation
Pain score
Respiratory rate
Sedation
During the stay in the operation room, an average of 50 minutes
Duration of surgery
During the stay in the operation room, an average of 60 minutes
Time to extubation
Hour 3
Duration of post-anesthesia care unit (PACU) stay
Hour 4
Drug dosages
during surgery, an average period of 50 minutes
Five-point surgical rating scale (SRS)

Trial Safety

Safety Estimate

1 of 3

Compared to trials

Trial Design

2 Treatment Groups

Moderate neuromuscular blockade (MNB)

This trial requires 30 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 and are in the first stage of evaluation with people.

Moderate neuromuscular blockade (MNB)The goal is to realize a moderate NMB (TOF 1-2 twitches). NMB will be induced with a bolus dose of rocuronium (Non-depolarizing Skeletal Neuromuscular Blocking Agent). If the target TOF values was not reached bolus doses of rocuronium (5 mg) will be given to achieve the target. This represents the standard care in our institution for this type of surgery. At the end of surgery, neuromuscular blockade in all patients will be reversed by sugammadex: patients in the moderate neuromuscular blockade group will receive sugammadex (Selective Relaxant Binding Agent).
Deep neuromuscular blockade (MNB)The goal is to realize a deep MNB (TOF zero twitches). NMB will be induced with a bolus dose of rocuronium (Non-depolarizing Skeletal Neuromuscular Blocking Agent). If the target TOF values was not reached bolus doses of rocuronium (5 mg) will be given to achieve the target. At the end of surgery, neuromuscular blockade in all patients will be reversed by sugammadex: patients in the deep neuromuscular blockade group will receive sugammadex (Selective Relaxant Binding Agent).

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: during the stay in the operation room, an average of 60 minutes
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly during the stay in the operation room, an average of 60 minutes for reporting.

Closest Location

MUHC - Montreal, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Elective vocal cord resection with an expected length of the procedure longer than 20 minutes and requiring jet ventilation

Patient Q&A Section

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Are there any geographic restrictions to consider when applying for this trial?

Patients from any state can participate in this trial, so long as they are able to attend all treatment sessions.

Will my insurance cover participating in this trial?

There is not cost involved in participating in this trial, so insurance won't be necessary.

See if you qualify for this trial
Get access to this novel treatment for Vocal Cord Resection by sharing your contact details with the study coordinator.