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Virus Therapy
Treatment (64CDP PET) for Cancer
Phase < 1
Waitlist Available
Led By Sagus Sampath
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up after administration of study treatment up to 1 month
Awards & highlights
Study Summary
This trial tests if using 64CDP with PET scans can find tumor cells in metastatic cancer patients. 64CDP is a compound with pembrolizumab & a radioactive substance to help evaluate response to treatment.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ after administration of study treatment up to 1 month
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after administration of study treatment up to 1 month
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in standard-uptake-value (SUV-max)
Changes in 64CDP uptake
Dose Limiting Toxicities (DLT)
+1 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Treatment (64CDP PET)Experimental Treatment3 Interventions
Patients receive standard of care pembrolizumab IV at baseline. Patients then receive 64CDP IV days 1 and 29 on study. Patients undergo PET scan on days 2 and 30 on study. Patients also undergo standard of care SBRT days 8-18.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positron Emission Tomography
2008
Completed Phase 2
~2240
Stereotactic Body Radiation Therapy
2012
Completed Phase 2
~780
Find a Location
Who is running the clinical trial?
City of Hope Medical CenterLead Sponsor
565 Previous Clinical Trials
1,921,460 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,657 Previous Clinical Trials
40,933,667 Total Patients Enrolled
Sagus SampathPrincipal InvestigatorCity of Hope Medical Center
1 Previous Clinical Trials
26 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have cancer that has spread to the brain, but you need to have another area of the body where radiation treatment is planned.You have advanced cancer that has spread to other parts of your body and you are currently receiving a medication called pembrolizumab. You have been recommended to receive a special type of radiation therapy called stereotactic body radiation therapy (SBRT) either to treat the main tumor or to target areas where the cancer is growing despite treatment.You cannot handle or tolerate a PET scan, even with anxiety-reducing medications.You have had a serious infection that needed strong antibiotics within the past 14 days before starting the study treatment.The areas in your body that need treatment with SBRT (stereotactic body radiation therapy) are in the lymph nodes, bone/spine, or lungs.
Research Study Groups:
This trial has the following groups:- Group 1: Treatment (64CDP PET)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any opportunities for volunteers to join this research endeavor?
"According to information presented on clinicaltrials.gov, this trial is not presently accepting patients for participation. The original posting was made on May 25th 2023 with the final edit being completed over two months later in February 13th 2023. Although this study has closed its recruitment period, 85 other trials are currently enrolling participants."
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