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HALIFAX

Queen Elizabeth II Health Sciences Centre

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HALIFAX, Nova Scotia B3H 2Y9

Global Leader in Breast Cancer

Global Leader in Multiple Myeloma

Conducts research for Prostate Cancer

Conducts research for Cancer

Conducts research for Crohn's Disease

372 reported clinical trials

31 medical researchers

Photo of Queen Elizabeth II Health Sciences Centre in HALIFAXPhoto of Queen Elizabeth II Health Sciences Centre in HALIFAXPhoto of Queen Elizabeth II Health Sciences Centre in HALIFAX

Summary

Queen Elizabeth II Health Sciences Centre is a medical facility located in HALIFAX, Nova Scotia. This center is recognized for care of Breast Cancer, Multiple Myeloma, Prostate Cancer, Cancer, Crohn's Disease and other specialties. Queen Elizabeth II Health Sciences Centre is involved with conducting 372 clinical trials across 387 conditions. There are 31 research doctors associated with this hospital, such as David P. Lee, MD, Ivan Wong, MD, Ricardo Rendon, MD, and Sudeep Shivakumar, MD.

Area of expertise

1

Breast Cancer

Global Leader

Queen Elizabeth II Health Sciences Centre has run 22 trials for Breast Cancer. Some of their research focus areas include:

Stage IV
Stage II
Stage I
2

Multiple Myeloma

Global Leader

Queen Elizabeth II Health Sciences Centre has run 22 trials for Multiple Myeloma. Some of their research focus areas include:

0
1
2

Top PIs

Clinical Trials running at Queen Elizabeth II Health Sciences Centre

Acute Myeloid Leukemia

Multiple Myeloma

Chronic Lymphocytic Leukemia

Idiopathic Pulmonary Fibrosis

Acute Myelogenous Leukemia

Cardiovascular Disease

Breast Cancer

Atrial Fibrillation

Pancreatic Cancer

Sarcoidosis

Image of trial facility.

Bleximenib + Venetoclax + Azacitidine

for Acute Myeloid Leukemia

The purpose of this study is to assess how bleximenib and Venetoclax (VEN)+ Azacitidine (AZA) works as compared to placebo and VEN+AZA alone for the treatment of participants with newly diagnosed Acute Myeloid Leukemia (AML) with a mutation in the NPM1 or KMT2A gene.

Recruiting

1 award

Phase 3

3 criteria

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Combination Therapies

for Acute Myeloid Leukemia

This phase II MyeloMATCH treatment trial compares cytarabine with daunorubicin versus cytarabine with daunorubicin and venetoclax versus venetoclax with azacitidine for the treatment of younger patients with intermediate risk acute myeloid leukemia (AML). Cytarabine is a drug that inhibits some of the enzymes needed for deoxyribonucleic acid (DNA) replication and repair and can slow or stop the growth of cancer cells. Daunorubicin is a drug that blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Azacitidine is a drug that interacts with DNA to activate tumor-suppressing genes, resulting in an anti-tumor effect. Adding venetoclax to cytarabine and daunorubicin, and adding venetoclax to azacitidine, may work better than the usual treatment of cytarabine with daunorubicin alone. To decide if they are better, the study doctors are looking to see if venetoclax increases the rate of elimination of AML in participants by 20% or more compared to the usual approach.

Recruiting

1 award

Phase 2

6 criteria

Image of trial facility.

Novel Therapies

for Acute Myeloid Leukemia

This phase II MyeloMATCH treatment trial tests whether the standard approach of cytarabine and daunorubicin in comparison to the following experimental regimens works to shrink cancer in patients with high risk acute myeloid leukemia (AML): 1) daunorubicin and cytarabine liposome alone; 2) cytarabine and daunorubicin with venetoclax; 3) azacitidine and venetoclax; 4) daunorubicin and cytarabine liposome and venetoclax. "High-risk" refers to traits that have been known to make the AML harder to treat. Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in the body. Daunorubicin is in a class of medications called anthracyclines. It also works by slowing or stopping the growth of cancer cells in the body. Azacitidine is in a class of medications called demethylation agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. There is evidence that these newer experimental treatment regimens may work better in getting rid of more AML compared to the standard approach of cytarabine and daunorubicin.

Recruiting

1 award

Phase 2

17 criteria

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