This trial is evaluating whether Calcium chloride will improve 1 primary outcome and 7 secondary outcomes in patients with Postpartum Hemorrhage. Measurement will happen over the course of Within 20 minutes of study drug administration.
This trial requires 120 total participants across 2 different treatment groups
This trial involves 2 different treatments. Calcium Chloride is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
"While some treatments are effective in reducing or preventing postpartum hemorrhage, this article looks at treatments that are commonly used. Most current evidence shows that an intervention, such as the use of an prophylactic oxytocin injection or the administration of a prostacyclin or vernicine, is cost effective for preventing postpartum hemorrhage. However, further study is needed to determine the cost effectiveness of other treatments." - Anonymous Online Contributor
"The present study found a significant non-randomized reduction in PPH rates in the intervention group at both 36 and 48 weeks (36 weeks: RR = 0.59 [0.45 to 0.79, p<0.01]; 48 weeks: RR = 0.59, [0.43 to 0.85, p< 0.0012]. This difference is not statistically significant, but supports our hypothesis regarding the benefits of routine postnatal follow-up. A randomized controlled trial (RCT)-analysis of our postintervention results would be required to confirm our findings, though this may not be achievable." - Anonymous Online Contributor
"There are no specific symptoms or signs that reliably indicate the severity of PPH. However, the signs and symptoms are similar to those of EOPH." - Anonymous Online Contributor
"Postpartum hemorrhage is the fifth leading cause of severe maternal morbidity. It occurs in approximately 10% of all deliveries; however, the incidence is higher in low-income countries, where the morbidity rate is as high as 20%. Postpartum hemorrhage is not unique to low-income countries. It occurs at all stages of pregnancy, including after the first trimester. Postpartum bleeding is usually a consequence of hemostatic deficits, which become more significant after delivery. Increased uterine blood flow after delivery is of major importance in the pathogenesis of postpartum hemorrhage." - Anonymous Online Contributor
"Incidence of postpartum hemorrhage in the United States was estimated to be about 5.2 per 100,000 live births, or 1.1 per 1000 women who delivered. Overall, about 6% of these women required medical intervention (i.e., were hospitalized) for postpartum hemorrhage." - Anonymous Online Contributor
"In the early postpartum period, bleeding in the postpartum period is not inevitable. A low blood volume state, such as that resulting from dehydration, can cause postpartum bleeding." - Anonymous Online Contributor
"The common side effects of calcium chloride are nausea, vomiting, and diarrhea. The side effect of low calcium levels is anemia. The most common side effect was low blood calcium. Some medications can enhance low blood calcium levels. Some of the side effects of low blood calcium can be avoided if the use of calcium can be adequately controlled." - Anonymous Online Contributor
"Calcium chloride is not a safe option for the treatment of postpartum hemorrhage. It provides no advantage in terms of morbidity or mortality. It also carries the risk of exacerbating the preexisting coagulopathy in patients with HELLP syndrome. However, the use of calcium chloride should be limited to the symptomatic treatment of pre-eclamptic patients." - Anonymous Online Contributor
"We did not find sufficient evidence to support or refute the use of calcium chloride after vaginal delivery. It is possible that calcium should not be prescribed to all patients and that further studies can identify important clinical groups for whom it may be beneficial." - Anonymous Online Contributor
"CaCl2 is not an effective drug for reducing or preventing postpartum hemorrhage. There is no evidence that it reduces the need for blood transfusion or prolongs labor. There are some potential effects that must be considered. There is a lack of information about its impact on newborns, the effect on growth, or the effects on the baby that results from breastfeeding. At present clinicians who use calcium for treating PPH are in the process of obtaining further information and knowledge to make more informed decisions." - Anonymous Online Contributor
"Results from a recent clinical trial, it was found that CaCl₂ for 12 g does not improve the QOL for women with PPH compared with placebo." - Anonymous Online Contributor
"The mortality of PPH is not greater than if the hemorrhage was from childbirth. The odds of needing a second delivery are not different between the puerperal hemorrhage survivors and other women with normal PPH; however, the women with PPH had an earlier delivery as well as requiring more health resources." - Anonymous Online Contributor