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Electrolyte

Calcium chloride for Postpartum Hemorrhage (CALBLOC Trial)

Phase 3
Waitlist Available
Led By Jessica Ansari, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2, 7, and 12 minutes after fetal delivery. the absolute 12 minute score as well as delta from 12-2 and 12-7 minute scores will be analyzed
Awards & highlights

CALBLOC Trial Summary

This trial will establish the effect of 1 gram of intravenous calcium chloride upon quantitative blood loss and uterine tone during cesarean delivery in parturients with high risk of uterine atony.

Eligible Conditions
  • Postpartum Hemorrhage
  • Uterine Atony
  • Uterine Atony With Hemorrhage
  • Cesarean Section Complications

CALBLOC Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~duration of operating room time
This trial's timeline: 3 weeks for screening, Varies for treatment, and duration of operating room time for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Quantitative Blood Loss
Secondary outcome measures
Change in hematocrit from baseline
Fluid requirement
Percent change in heart rate from baseline
+8 more

CALBLOC Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Calcium chlorideExperimental Treatment1 Intervention
1 gram of calcium chloride in total volume 60mL with sterile saline, delivered over 10 minute controlled infusion at a constant rate (360mL/hour) beginning 2 minutes after fetal delivery and 1 minute after delayed cord clamp. This intervention occurs IN ADDITION TO standard care with oxytocin 2 unit bolus and infusion at 7.5 units per hour which begins immediately after fetal delivery.
Group II: Saline placeboPlacebo Group1 Intervention
60mL sterile saline, delivered over 10 minute controlled infusion at a constant rate (360mL/hour) beginning 2 minutes after fetal delivery and 1 minute after delayed cord clamp. This intervention occurs IN ADDITION TO standard care with oxytocin 2 unit bolus and infusion at 7.5 units per hour which begins immediately after fetal delivery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Calcium chloride
2022
Completed Phase 3
~170

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,387 Previous Clinical Trials
17,333,930 Total Patients Enrolled
4 Trials studying Postpartum Hemorrhage
15,125 Patients Enrolled for Postpartum Hemorrhage
Jessica Ansari, MDPrincipal InvestigatorStanford University

Media Library

Calcium chloride (Electrolyte) Clinical Trial Eligibility Overview. Trial Name: NCT05027048 — Phase 3
Postpartum Hemorrhage Research Study Groups: Saline placebo, Calcium chloride
Postpartum Hemorrhage Clinical Trial 2023: Calcium chloride Highlights & Side Effects. Trial Name: NCT05027048 — Phase 3
Calcium chloride (Electrolyte) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05027048 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you please share how many people are involved in this research project?

"As of right now, this clinical trial is not looking for any more patients. This information was taken from the date that the trial was first posted (1/1/2023) and when it was last edited (2/4/2022). However, there are currently 416 trials actively recruiting patients with postpartum hemorrhage and 13 studies seeking participants for Calcium chloride research."

Answered by AI

How can I become a part of this experiment?

"Women who have recently given birth and are between 18-55 years old may be accepted into this study on postpartum hemorrhage. A total of 120 patients will be enrolled."

Answered by AI

For what sorts of medical conditions is calcium chloride regularly employed?

"More often than not, calcium chloride is used to treat kidney failure that has come on suddenly. That being said, it can also be an effective way to manage other conditions like calcium channel blockers, diarrhea, and beta blocker overdoses."

Answered by AI

What other research studies have used Calcium chloride as a treatment?

"There are currently 13 active clinical trials investigating the use of calcium chloride, with 3 of those trials in Phase 3. Most of the studies for calcium chloride are being conducted out of Pittsburgh, Pennsylvania, but there are 17 total locations where studies are taking place."

Answered by AI

Are the subjects of this research project restricted to a certain age group?

"Individuals who are between 18-55 years old may participate in this clinical trial."

Answered by AI

Are participants being enrolled in this experiment right now?

"This study is no longer looking for participants. Trial information indicates that the first posting was on 1/1/2023 and the last update occurred on 2/4/2022. There are other options available, including 416 clinical trials searching for patients with postpartum hemorrhage and 13 studies involving calcium chloride currently enrolling new participants."

Answered by AI

Has the FDA cleared calcium chloride for use?

"There is some clinical data that supports the efficacy of calcium chloride, and it has received multiple rounds of support for safety, so we have given it a score of 3."

Answered by AI
~40 spots leftby Apr 2025