No Placebo-Only Group

RATIONALE: Photodynamic therapy uses light and photosensitizing drugs to kill tumor cells and may be an effective treatment for refractory brain tumors.

PURPOSE: This phase I trial is studying the side effects and best dose of photodynamic therapy using porfimer sodium in treating patients with refractory brain tumors, including astrocytoma, ependymoma, and medulloblastoma.

Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors

Photodynamic Therapy for Brain Cancer

This study is evaluating whether photodynamic therapy is safe and effective for treating brain tumors.

I haven't had cancer in the last 5 years, except for skin cancer.

My cancer is in one place or has only spread to one other spot.

My tumor has come back or is growing and cannot be removed with surgery.

I have been diagnosed with a brain tumor.

My condition did not improve after standard treatments, including radiation.

I have had a condition where my lymphocytes grow abnormally.

My liver blood tests (PT and PTT) are normal.

My cancer can be reached with light treatment.

Photodynamic Therapy

Porfimer Sodium

RATIONALE: Peripheral stem cell transplantation may allow doctors to give higher doses of chemotherapy drugs and kill more cancer cells.

PURPOSE: Phase II trial to study the effectiveness of peripheral stem cell transplantation in treating patients who have multiple myeloma or other B-cell cancers.

Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Other B-cell Cancers

Peripheral Stem Cell Transplantation for Multiple Myeloma

This study is evaluating whether a stem cell transplant can improve the effectiveness of chemotherapy.

My lymphoma is a type of T-cell non-Hodgkin's.

I can care for myself but may not be able to do active work.

I do not have an infection or fever that needs strong antibiotics.

I have been diagnosed with a specific type of blood cancer.

It has been over 2 weeks since my last biologic therapy.

My lung function tests are at least half of what's expected for someone my age and size.

It's been over 2 weeks since my last hormone therapy.

My heart's pumping ability is at least 40%.

It's been over 2 weeks since my last chemotherapy and I've recovered.

Peripheral Stem Cell Transplantation

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with metastatic, recurrent, or unresectable cancer of the esophagus.

Paclitaxel in Treating Patients With Metastatic, Recurrent, or Unresectable Cancer of the Esophagus

Paclitaxel for Esophageal Cancer

This study is evaluating whether paclitaxel is effective in treating esophageal cancer.

I haven't had chemotherapy in the last 4 weeks.

I do not have severe numbness or pain in my hands or feet.

I have not had a heart attack in the last 6 months.

I am able to get out of my bed or chair and move around.

My heart condition does not severely limit my daily activities.

I have had only one chemotherapy treatment before.

I haven't had radiotherapy in the last 4 weeks.

My cancer mainly affects my esophagus or where my stomach meets my esophagus.

I have not received treatment for cancer that has spread.

My cancer is a type of esophageal cancer that cannot be removed by surgery.

I have had only one chemotherapy or radiation treatment before surgery or additional therapy.

I had skin cancer treated with the goal of curing it.

My cervical cancer was treated with the intent to cure.

Less than 30% of my bone marrow has been exposed to radiation.

I am not currently undergoing radiotherapy.

I do not have serious heart fluid buildup or irregular heartbeat.

My cancer can be measured or seen on tests.

I do not have any serious infections or illnesses.

My stomach cancer has barely spread to the junction or lower esophagus.

My cancer has not spread to the bones only.

I haven't had immunotherapy in the last 4 weeks.

I am not currently on any immunotherapy treatments.

I am not currently receiving chemotherapy.

I haven't had hormonal therapy in the last 4 weeks.

I have not had any surgery in the last 2 weeks.

I haven't had any injected antibiotics in the last week.

Paclitaxel

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with recurrent or refractory head and neck cancer.

Paclitaxel in Treating Patients With Recurrent or Refractory Head and Neck Cancer

Paclitaxel for Recurrent or Refractory Head and Neck Cancer

This study is evaluating whether paclitaxel is effective in treating head and neck cancer.

My head or neck cancer has come back or is not responding to treatment.

It's been over 3 weeks since my last immunotherapy and I'm not currently on it.

My heart is generally healthy with no recent major issues.

I haven't had certain strong cancer drugs for at least 5 weeks, and other chemotherapy for 3 weeks.

I stopped hormonal therapy 3 weeks ago, but I may be taking Megace.

I haven't had radiotherapy in the last 3 weeks and none of my treatments targeted more than 30% of my bone marrow.

My kidney function is within the required range and my calcium levels are normal.

I have had chemotherapy before for my cancer that came back or spread.

My liver function tests are within normal limits.

It has been over 3 weeks since I had major surgery.

Pivotal Trial

RATIONALE: Interferon alfa may interfere with the growth of cancer cells. It is not yet known whether treatment with interferon alfa is more effective than observation alone for stage II or stage III melanoma that has been completely removed surgically.

PURPOSE: This randomized phase III trial is studying high dose interferon alfa to see how well it works compared to observation only in treating patients with stage II or stage III melanoma that has been completely removed by surgery.

High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma

High-Dose Interferon Alfa for Melanoma

This study is evaluating whether interferon alfa can improve survival for people with melanoma.

My skin cancer is at Stage II with a thickness of 1.5-4.0 mm.

My lymph nodes do not show signs of cancer, either by clinical exam or biopsy.

My cancer is stage III with a tumor thicker than 4mm or has spread to one lymph node.

Interferon alfa-2b

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known if chemotherapy is more effective with or without monoclonal antibody therapy for acute myelogenous leukemia.

PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without monoclonal antibody therapy in treating patients who have refractory or relapsed acute myelogenous leukemia.

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia

Combination Chemotherapy + Monoclonal Antibody for Acute Myeloid Leukemia

This study is evaluating whether chemotherapy with or without monoclonal antibodies is more effective for treating people with acute myelogenous leukemia.

I will use effective birth control during and for 1 month after the study.

I have a serious infection that isn't getting better with treatment.

I have been diagnosed with acute myelogenous leukemia.

My bilirubin level is above 2.0 mg/dL, not due to Gilbert's disease or leukemia.

My heart's left ventricle isn't working properly.

I haven't had recent serious heart problems.

I can perform most of my daily activities without assistance.

I do not have leukemia in my brain or spinal cord.

I do not have any other cancer that needs treatment.

My blood, liver, kidney, and heart meet the trial's health requirements.

I do not have leukemia in an advanced stage.

I am currently receiving treatment for cancer.

I do not have any serious infections that aren't controlled by medication.

Cytarabine

Daunorubicin

Monoclonal Antibody Therapy

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of carmustine in treating patients who have progressive or recurrent glioblastoma multiforme.

Carmustine in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Carmustine for Glioblastoma

This study is evaluating whether carmustine is effective in treating people with glioblastoma multiforme.

My cancer has not spread into the brain's ventricular system.

I have been diagnosed with a specific brain cancer called glioblastoma.

I have not taken any blood thinners before.

My brain condition does not affect my main sensory or motor areas, vision, or other cranial nerves.

My tumor has a thick outer layer, even if it's partly hollow or dead inside.

My cancer has not spread to the brainstem or midbrain.

I have undergone radiotherapy at least once.

My kidney function tests are within the required range.

My tumor cannot be removed surgically and is round in shape.

Carmustine

RATIONALE: Light-emitting diode (LED) therapy may be able to prevent mucositis of the mouth.

PURPOSE: Randomized phase II trial to determine the effectiveness of LED therapy in preventing mucositis of the mouth in children who are receiving chemotherapy with or without radiation therapy before donor bone marrow transplantation.

Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation

LED Therapy for Mucositis Prevention in Children Undergoing Bone Marrow Transplant

This study is evaluating whether LED therapy can prevent mucositis in children who are receiving chemotherapy.

I am either younger than 2 years old or older than 18 years old.

I can stay calm during LED therapy and oral exams.

I am preparing for my first bone marrow transplant with intensive treatment.

I am taking medication that makes my skin or eyes sensitive to light.

My lungs work well enough not to need a breathing tube in the first 3 weeks after a transplant.

Chemotherapy

Light-Emitting Diode Therapy

Radiation Therapy

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of BAY 59-8862 in treating patients who have refractory non-Hodgkin's lymphoma.

BAY 59-8862 in Treating Patients With Refractory Non-Hodgkin's Lymphoma

BAY 59-8862 for Non-Hodgkin's Lymphoma

This study is evaluating whether a drug can stop cancer cells from dividing.

My cancer spots in previously treated areas can't be used to measure my disease.

I have not had a cancer relapse within 6 months after my bone marrow transplant.

I have not had a bone marrow or stem cell transplant.

My brain and spinal cord are free from cancer, or I meet specific conditions if they are not.

My lymphoma is aggressive and not responding to treatment, and I need chemotherapy.

My blood counts meet the required levels.

My heart health meets the study requirements.

I do not have any serious infections right now.

My liver function meets the required standards.

My kidney function is within the required range.

I have no other cancer except for certain allowed types.

My previous cancer treatment didn't work, or my cancer returned within 6 months.

BAY 59-8862

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of BAY 59-8862 in treating patients who have advanced kidney cancer.

BAY 59-8862 in Treating Patients With Advanced Kidney Cancer

BAY 59-8862 for Kidney Cancer

I had brain or meningeal tumors treated over 6 months ago, with no recent growth.

My kidney function, measured by creatinine, is within normal limits.

My heart is healthy with no failure, serious rhythm problems, or past heart disease.

I have not had a severe allergic reaction to taxane drugs that couldn't be managed.

I haven't had any cancer in the last 3 years, except for specific non-aggressive types.

I have not received hormonal therapy for kidney cancer.

I am not currently receiving any experimental or approved cancer treatments.

I am not taking bisphosphonates for bone health or cancer spread to bones, unless my doctor said it's okay.

My target lesion for this study has not received prior radiotherapy, or if it has, the cancer within that area has gotten worse.

I am not on blood thinners, or my blood clotting tests are normal if I am.

I have not had chemotherapy that travels through my bloodstream to reach cancer cells anywhere in my body.

I am not receiving any other cancer treatments.

My cancer has spread beyond just my brain.

My liver function tests are within acceptable ranges and I don't have chronic hepatitis B or C.

I had seizures from brain cancer but have been seizure-free for 2 months.

I am not currently on any steroid treatments.

I am not using herbs, acupuncture, or supplements that could affect the study.

My kidney cancer is confirmed by lab tests.

I have never received an organ transplant.

My cancer spots in areas treated with radiation are not counted as measurable.

I have never been treated with oxaliplatin.

My cancer cannot be removed by surgery and has spread.

I had brain or meningeal tumors treated over 6 months ago, am stable, and recent scans are clear.

RATIONALE: Drugs used in chemotherapy, such as pixantrone, cytarabine, methylprednisolone, and cisplatin, work in different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have relapsed aggressive non-Hodgkin's lymphoma.

Pixantrone, Cytarabine, Methylprednisolone, and Cisplatin in Treating Patients With Aggressive Non-Hodgkin's Lymphoma in First Relapse

Chemotherapy Combination for Non-Hodgkin's Lymphoma

This study is evaluating whether a combination of drugs can improve the survival of people with aggressive non-Hodgkin's lymphoma.

My cancer worsened only once after responding to chemotherapy.

I have a history of lymphoblastic lymphoma or mantle cell lymphoma.

My condition did not improve after chemotherapy.

My creatinine level is 1.5 mg/dL or lower.

My cancer is only in my bone marrow and does not have a measurable tumor.

My liver function tests are within the required limits.

I am fully active or able to carry out light work.

My lymphoma is aggressive and confirmed by a biopsy.

My heart functions well, with no recent heart attacks or severe irregular heartbeats.

Cisplatin

Methylprednisolone

Pixantrone

This randomized phase IIB trial studies imatinib mesylate at two different doses and dasatinib to see how well they work in treating patients with previously untreated chronic phase chronic myelogenous leukemia. Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia

Imatinib or Dasatinib for Chronic Myeloid Leukemia

This study is evaluating whether a drug called imatinib mesylate or dasatinib can stop the growth of cancer cells in patients with chronic myelogenous leukemia.

I haven't had major surgery in the last 28 days and have recovered from past surgeries.

My CML is in the chronic phase, confirmed by recent tests.

I can take care of myself and am up and about more than 50% of my waking hours.

My heart is healthy and I've had an ECG test in the last 42 days without major issues.

I was diagnosed with CML within the last 6 months and tested positive for the Philadelphia chromosome.

I have CML and have only been treated with hydroxyurea or anagrelide.

I haven't had chemotherapy for stem cell mobilization.

I do not have a history of serious bleeding disorders not related to my cancer.

I have no cancer history except for certain skin cancers, early-stage cancers in remission, or any cancer I've been free from for 5 years.

Medical College Of Wisconsin Clinical Trials 2022

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