Ilevro

Chronic Pain, Inflammation, Cataract Surgery
Treatment
5 FDA approvals
20 Active Studies for Ilevro

What is Ilevro

NepafenacThe Generic name of this drug
Treatment SummaryNepafenac is a medication used to treat pain and inflammation after cataract surgery. It is an NSAID (non-steroidal anti-inflammatory drug) that comes in the form of a prescription eye drop.
Nevanacis the brand name
image of different drug pills on a surface
Ilevro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nevanac
Nepafenac
2005
5

Approved as Treatment by the FDA

Nepafenac, also known as Nevanac, is approved by the FDA for 5 uses like Pain and Inflammation .
Pain
Helps manage Pain
Inflammation
Helps manage Inflammation
Chronic Pain
Helps manage Pain
Cataract Surgery
Helps manage Cataract Surgery
Inflammation
Helps manage Inflammation

Effectiveness

How Ilevro Affects PatientsWhen Nepafenac ophthalmic suspension is taken three times a day, measurable amounts of Nepafenac and Amfenac are present in the blood after two and three hours respectively. On average, the maximum amount of Nepafenac and Amfenac in the blood was 0.310 and 0.422 nanograms per milliliter, respectively.
How Ilevro works in the bodyNepafenac is a drug that is changed in the body to amfenac, a type of pain reliever. Amfenac works by blocking the activity of two enzymes, COX1 and COX2. This helps reduce inflammation and pain.

When to interrupt dosage

The recommended measure of Ilevro is contingent upon the diagnosed condition, for example Inflammation, Cataract Surgery and Chronic Pain. The quantity of dosage fluctuates, according to the administration mode (e.g. Suspension / drops or Ophthalmic) featured in the table beneath.
Condition
Dosage
Administration
Chronic Pain
, 1.0 mg/mL, 3.0 mg/mL, 0.3 %, 0.1 %
Suspension / drops - Ophthalmic, , Ophthalmic, Suspension / drops, Suspension, Suspension - Ophthalmic
Cataract Surgery
, 1.0 mg/mL, 3.0 mg/mL, 0.3 %, 0.1 %
Suspension / drops - Ophthalmic, , Ophthalmic, Suspension / drops, Suspension, Suspension - Ophthalmic
Inflammation
, 1.0 mg/mL, 3.0 mg/mL, 0.3 %, 0.1 %
Suspension / drops - Ophthalmic, , Ophthalmic, Suspension / drops, Suspension, Suspension - Ophthalmic

Warnings

Ilevro Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Ilevro.
Common Ilevro Drug Interactions
Drug Name
Risk Level
Description
Valproic acid
Minor
The protein binding of Valproic acid can be decreased when combined with Nepafenac.
Acemetacin
Moderate
The risk or severity of adverse effects can be increased when Nepafenac is combined with Acemetacin.
Acetylsalicylic acid
Moderate
The therapeutic efficacy of Acetylsalicylic acid can be decreased when used in combination with Nepafenac.
Alclofenac
Moderate
The risk or severity of adverse effects can be increased when Nepafenac is combined with Alclofenac.
Alminoprofen
Moderate
The risk or severity of adverse effects can be increased when Nepafenac is combined with Alminoprofen.
Ilevro Toxicity & Overdose RiskApplying non-steroidal anti-inflammatory drugs to the eyes can lead to increased bleeding in the eye area during eye surgery.
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Ilevro Novel Uses: Which Conditions Have a Clinical Trial Featuring Ilevro?

357 active studies are currently being undertaken to assess the potential of Ilevro in alleviating Inflammation, Chronic Pain and assisting with Cataract Surgery.
Condition
Clinical Trials
Trial Phases
Inflammation
58 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
Chronic Pain
130 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1
Cataract Surgery
3 Actively Recruiting
Not Applicable, Phase 4

Ilevro Reviews: What are patients saying about Ilevro?

5Patient Review
8/28/2016
Ilevro for Inflammation of the Eye Following Surgery
I took this treatment once a day for 7 days, and then due to irritation from the antibiotic, I dropped down to 2 drops a day for 7 days. I had a sample bottle which only lasted me until day 11. From my experience, I think that one bottle would last if you're only taking 1 drop a day for two weeks. However, since I ran out before finishing the full 14 days, I had to get a prescription for the other eye. This medication is pricey, but my insurance did give me a special authorization and covered it.
5Patient Review
6/17/2017
Ilevro for Inflammation of the Eye Following Surgery
Helped to relieve pain after a failed glaucoma surgery. Not as easy to apply as OTC eyedrops, but this was much more effective and long-lasting.
4Patient Review
10/29/2013
Ilevro for Inflammation of the Eye Following Surgery
3.3Patient Review
1/1/2014
Ilevro for Inflammation of the Eye Following Surgery
The bottle was very small and expensive. The design of the bottle tip was such that the medication would drip down the side of the bottle after application, wasting a small amount each time. Other eye drops I used had better tip design.
3Patient Review
3/22/2019
Ilevro for Inflammation of the Eye Following Surgery
I used this once in the morning and evening for cataracts/LASIK and it did the job well. The only side effect was temporary blurring, but that was manageable. The bottle is really difficult to use though.
2Patient Review
3/26/2016
Ilevro for Postoperative Pain in Eye
The bottle is rigid, and the fluid inside is very viscous. It barely lasted me three weeks. Since it's not a covered medication, unless you're careful with your usage, you'll end up having to pay for another bottle before you're supposed to.
1.7Patient Review
8/8/2014
Ilevro for Postoperative Pain in Eye
The design of this dropper is very poor. There is only enough medicine for 25 days, so you have to be careful when using it.
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Patient Q&A Section about ilevro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Ilevro used for?

"This medication is used to relieve eye pain, irritation, and redness following cataract eye surgery. Nepafenac belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs work by reducing swelling and inflammation."

Answered by AI

What are the side effects of Ilevro eye drops?

"The sensation of a foreign body in the eye, increased intraocular pressure, a sticky sensation in the eye, eye or eyelid swelling, dry eye, crusting of the eyelids, eye discomfort or pain, and itchy eyes are all symptoms of conjunctivitis."

Answered by AI

What kind of drug is Ilevro?

"Ilevro is a non-steroidal anti-inflammatory drug (NSAID) that lessens pain and swelling in the eye due to surgery by stopping your body from making chemicals that cause inflammation."

Answered by AI

Is Ilevro a generic drug?

"At the moment, there is no cheaper alternative to Ilevro that has the same therapeutic effect in the United States. Be aware that there are many illegal online pharmacies that might try to sell you a generic version of Ilevro. These medicines could be fake and potentially dangerous."

Answered by AI

Clinical Trials for Ilevro

Image of University of California, San Francisco in San Francisco, United States.

Vision Centers for Eye Care

Any Age
All Sexes
San Francisco, CA
The goal of this clinical trial is to evaluate the effect of vision centers on access to eye care and eye health outcomes in South Asia. The main questions it aims to answer are: 1. Do vision centers increase visits to eyecare centers? 2. Do vision centers increase spectacle ownership and wearing? 3. Do vision centers improve visual acuity of the population? Researchers will compare outcomes in communities randomized to have a vision center is established with communities randomized to delay establishment of a vision center. Outcomes will be assessed through population-based surveys at baseline and after two years as well as through hospital records collected throughout the study period.
Waitlist Available
Has No Placebo
University of California, San FranciscoKieran O'Brien, PhD, MPH
Have you considered Ilevro clinical trials? We made a collection of clinical trials featuring Ilevro, we think they might fit your search criteria.Go to Trials
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Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Image of Baylor College of Medicine/Texas Children's Hospital in Austin, United States.

Guided Imagery Therapy for Abdominal Pain

7 - 12
All Sexes
Austin, TX
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet. Participants will complete a baseline abdominal pain and stooling diary to determine eligibility, as well as other surveys. Eligible participants will be given access to the guided imagery therapy mobile application. This intervention asks participants to listen to a 10- to 15-minute GIT session 5 out of 7 days per week for 8 weeks, in addition to their usual care for their abdominal pain. Then, participants will complete another abdominal pain and stooling diary, along with other psychometric surveys, at the end of this intervention period. Participants will also collect another diary and surveys 3 months post-treatment.
Waitlist Available
Has No Placebo
Baylor College of Medicine/Texas Children's Hospital (+1 Sites)
Have you considered Ilevro clinical trials? We made a collection of clinical trials featuring Ilevro, we think they might fit your search criteria.Go to Trials
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Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
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Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)
Waitlist Available
Has No Placebo
UConn HealthCutter Lindbergh, Ph.D.
Have you considered Ilevro clinical trials? We made a collection of clinical trials featuring Ilevro, we think they might fit your search criteria.Go to Trials
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