Cognitive Remediation for Memory and Thinking Difficulties
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a brain training program called Computerized Cognitive Remediation to determine its effectiveness for older adults with memory or thinking problems after recovering from COVID-19. Researchers aim to discover if this program can improve daily life and cognitive function over time. Participants will be compared to those engaged in different computer activities to assess effectiveness. Suitable candidates are adults aged 60 or older who have experienced memory or thinking issues for at least 12 weeks following a confirmed COVID-19 infection. As an unphased trial, this study provides a unique opportunity for participants to contribute to research that could enhance cognitive health in older adults.
Will I have to stop taking my current medications?
The trial requires that if you are on psychiatric medication, you must be on a stable dose for at least 8 weeks before participating. Other medications are not specifically mentioned, so it's best to discuss with the trial team.
What prior data suggests that this computerized cognitive remediation is safe for older adults with postviral neurocognitive dysfunction?
Research has shown that computerized cognitive exercises are generally easy for participants to handle. In one study, these exercises had a small to moderate positive impact on attention and memory. Participants reported no major side effects, indicating safety for most people. Another review found that similar brain training activities might improve overall brain function in individuals with mild memory problems. This suggests these exercises could safely boost memory and thinking skills in older adults.12345
Why are researchers excited about this trial?
Researchers are excited about computerized cognitive remediation because it offers a novel approach to addressing memory and thinking difficulties. Unlike traditional treatments that may rely on medication or in-person therapy sessions, this method uses interactive computer-based exercises designed to enhance cognitive function through regular practice. This approach is accessible and adaptable, allowing users to engage with the treatment at their own pace and in their preferred environment. Additionally, the use of technology in treatment delivery is promising for its potential to reach a broader audience, making cognitive remediation more widely available.
What evidence suggests that this computerized cognitive remediation is effective for postviral neurocognitive dysfunction?
Research has shown that computerized brain training can improve thinking and memory, particularly for individuals with mild memory problems. In this trial, participants will receive either Computerized Cognitive Remediation or an Active Computer-Based Control. Studies have found small but meaningful improvements in overall brain function for users of these programs compared to non-users. Participants using these tools have demonstrated faster thinking and enhanced planning and problem-solving skills. Although the benefits for those with more severe memory issues are less pronounced, the results are promising for those with mild concerns. Overall, these programs provide helpful support for older adults needing a little extra assistance with their mental skills.25678
Who Is on the Research Team?
Cutter Lindbergh, Ph.D.
Principal Investigator
UConn Health
Are You a Good Fit for This Trial?
This trial is for English-speaking adults aged 60 or older who have had COVID-19, confirmed by testing, and are experiencing lasting cognitive issues like memory or thinking problems for at least 12 weeks. Participants should show signs of cognitive decline but not be affected by severe psychiatric illnesses, dementia, substance abuse in the last two years, significant neurological disorders, sensory impairments that affect tablet use, or a history of neurodevelopmental conditions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants engage in computerized cognitive remediation activities for approximately 5 hours per week over 6 weeks, with weekly remote check-ins and two blood draw sessions.
Post-Treatment Assessment
Participants undergo assessments of cognitive, emotional, and daily functioning.
Follow-up
Participants are monitored for cognitive performance and other outcomes at a 6-month follow-up visit.
What Are the Treatments Tested in This Trial?
Interventions
- Computerized Cognitive Remediation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Cutter Lindbergh
Lead Sponsor
National Institute on Aging (NIA)
Collaborator