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What is Urocit-K
Potassium citrateThe Generic name of this drug
Treatment SummaryPotassium citrate, also known as tripotassium citrate, is a white, odorless powder with a salty taste. It is made up of 38.3% potassium. When mixed with water, it becomes highly hygroscopic and deliquescent. Potassium citrate is used to treat kidney stones and renal tubular acidosis. It is also used to manage a condition called hypocitraturic calcium oxalate nephrolithiasis.
Urocit-Kis the brand name
Urocit-K Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Urocit-K
Potassium citrate
1985
60
Approved as Treatment by the FDA
Potassium citrate, otherwise called Urocit-K, is approved by the FDA for 5 uses like uric acid and NEPHROLITHIASIS, CALCIUM OXALATE .uric acid
NEPHROLITHIASIS, CALCIUM OXALATE
Helps manage Hypocitraturic calcium oxalate nephrolithiasis
Lithiasis
Helps manage uric acid lithiasis
Nephrolithiasis
Renal tubular acidosis
Helps manage Tubular Acidosis; Renal
Effectiveness
How Urocit-K Affects PatientsPotassium citrate helps to prevent the formation of crystals and stones in the urine from salt compounds such as calcium oxalate, calcium phosphate and uric acid. It does this by increasing the citrate levels in the urine and binding with calcium, which decreases the activity of calcium ions and reduces the chances of calcium phosphate crystals forming. Additionally, it can stop the crystals from forming on their own.
How Urocit-K works in the bodyPotassium citrate, taken orally, breaks down in the body to form an alkaline load. This then increases the amount of citrate in urine and raises the pH level, while also increasing the potassium level. In some cases, this can lead to a decrease in the amount of calcium in the urine.
When to interrupt dosage
The suggested amount of Urocit-K is contingent upon the diagnosed condition, including Metabolic Acidosis, laxative and Renal tubular acidosis. The dosage varies as per the mode of administration (e.g. Solution - Oral or Liquid) stated in the table beneath.Condition
Dosage
Administration
Uremia
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Lithiasis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
uric acid
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Metabolic Acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Constipation
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Bowel preparation therapy
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Nephrolithiasis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Kidney Stones
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
NEPHROLITHIASIS, CALCIUM OXALATE
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Renal tubular acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Metabolic acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
laxative
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Gout Flares
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Warnings
Urocit-K ContraindicationsCondition
Risk Level
Notes
Hyperkalemia
Do Not Combine
Impaired Renal Function
Do Not Combine
Urinary tract infection
Do Not Combine
Gastrointestinal tract structure
Do Not Combine
Peptic Ulcer Disease
Do Not Combine
Common Urocit-K Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The excretion of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when combined with Potassium citrate.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The excretion of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when combined with Potassium citrate.
4-Bromo-2,5-dimethoxyamphetamine
Major
The excretion of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when combined with Potassium citrate.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Potassium citrate.
Amiloride
Major
The risk or severity of hyperkalemia can be increased when Potassium citrate is combined with Amiloride.
Urocit-K Toxicity & Overdose RiskThe toxic dose of the drug for dogs is 176mg/kg when administered intravenously.
Urocit-K Novel Uses: Which Conditions Have a Clinical Trial Featuring Urocit-K?
A total of 74 active clinical trials are assessing the potential of Urocit-K to provide Bowel preparation therapy, Kidney Stone Dissolution and Chronic Constipation Relief.Condition
Clinical Trials
Trial Phases
Constipation
38 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1
Kidney Stones
45 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 3, Phase 4, Phase 1
Bowel preparation therapy
2 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Metabolic acidosis
0 Actively Recruiting
NEPHROLITHIASIS, CALCIUM OXALATE
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
Lithiasis
0 Actively Recruiting
uric acid
1 Actively Recruiting
Phase 4
Metabolic Acidosis
4 Actively Recruiting
Phase 2, Phase 4, Phase 1
Uremia
0 Actively Recruiting
Renal tubular acidosis
0 Actively Recruiting
laxative
0 Actively Recruiting
Urocit-K Reviews: What are patients saying about Urocit-K?
4.7Patient Review
3/11/2013 I took this for around eight months while I was deployed to Afghanistan. It was great because it's hard to diet there, and I had no side effects or stones. But then I got lazy and stopped taking it for a couple months, and that resulted in a small stone. So now I'm back on the medication again.
4Patient Review
3/3/2009 I'm not usually one for taking medication, but this has been a lifesaver. I've been kidney stone free for almost two years now, and it's all thanks to this little pill. They're tough to swallow (literally), but I know it's worth it.
3.7Patient Review
12/30/2008 The pills are large and not coated, making them hard to swallow. I've only just started taking the medication so I can't speak to its efficacy yet.
3Patient Review
1/23/2010 I've only been on this medication for a week, but I have experienced significant heartburn relief. Additionally, this week I passed five kidney stones.
2.7Patient Review
2/1/2009 I take it with meals to avoid the upset stomach that it sometimes causes. I use cold juice to help it go down. When I take it regularly, it seems to decrease the frequency of kidney stones (with the drug: one stone every ~10 yrs; without the drug: one stone every ~5 yrs).
2.7Patient Review
1/9/2014 I had some initial digestive issues with this medication, but those subsided after a few days. I continued to feel lousy for weeks afterwards though and stopped taking the drug as a result. However, since it could still be beneficial to me, I started taking it again. Unfortunately, my vision has changed since being on the medication (not a listed side effect) so now I need different glasses.
2.7Patient Review
2/29/2012 My urologist believes that this medication will help me avoid future kidney stones, for which I've needed surgery in the past. The pills are large and very hard to swallow--they start dissolving as soon as you put them in your mouth! I have to take four per day, and it's easier to just down all my other pills at once than try to choke these things down one by one.
2.3Patient Review
9/16/2015 I had to have six laser lithotripsy treatments to remove five stones that were too big to pass. It's only been two years and I've already made three more stones. I'm hoping this medication helps.
1.7Patient Review
9/26/20071.7Patient Review
12/1/2008 I felt shaky and nauseous after taking this medication.
1.3Patient Review
10/13/2013 I am currently taking this medication for fibromyalgia. So far, I have not seen any improvement in my pain levels.
1Patient Review
9/12/2009 As long as you follow the instructions, this medication will help prevent kidney stones from forming.
Patient Q&A Section about urocit-k
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Urocit-K the same as potassium citrate?
"Potassium citrate alters the pH of urine, making it less acidic. This allows the kidneys to excrete uric acid more efficiently, reducing the risk of kidney stones."
Answered by AI
What is Urocit-K used for?
"This medication is used in order to make the urine less acidic. The purpose of this is to help the kidneys get rid of uric acid, which also helps to prevent gout and kidney stones. This medication can also be used to prevent and treat certain metabolic problems (acidosis) that are caused by kidney disease."
Answered by AI
What are the side effects of Urocit-K?
"You may experience some side effects when taking potassium citrate, including nausea, vomiting, diarrhea, stomach pain or upset, or the appearance of a potassium citrate tablet in your stool."
Answered by AI
Is Urocit-K over the counter?
"Urocit-K is a prescription medication that helps to prevent kidney stones by restoring the chemical balance in the kidneys. It is available in three different dosage strengths, and reduces the formation of several common types of kidney stones, including calcium oxalate and uric acid stones."
Answered by AI