PT-112 for Thymic Epithelial Tumors

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
National Institutes of Health Clinical Center, Bethesda, MDThymic Epithelial Tumors+2 MorePT-112 - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing the drug PT-112 to see if it can help people with thymoma or thymic cancer whose disease returned or progressed after treatment with at least one platinum-containing chemotherapy.

Eligible Conditions
  • Thymic Epithelial Tumors
  • Recurrent Thymoma
  • Thymic Cancer

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: assessed every 8 weeks while on treatment and then every 3 months after that for a maximum of 8 years from the start of study

Month 3
duration of response (DOR)
progression-free survival (PFS)
Year 8
overall response rate (ORR)
Month 3
overall survival (OS)
safety data routinely collected from initiation of study therapy through long term follow up
safety of PT-112
start of the treatment until disease progression/recurrence
overall response rate (ORR) based on ITMIG modified RECIST (ITMIG)

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Similar Trials

Trial Design

1 Treatment Group

PT-112
1 of 1

Experimental Treatment

53 Total Participants · 1 Treatment Group

Primary Treatment: PT-112 · No Placebo Group · Phase 2

PT-112
Drug
Experimental Group · 1 Intervention: PT-112 · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PT-112
2017
Completed Phase 1
~30

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: assessed every 8 weeks while on treatment and then every 3 months after that for a maximum of 8 years from the start of study

Who is running the clinical trial?

National Cancer Institute (NCI)Lead Sponsor
13,153 Previous Clinical Trials
41,162,871 Total Patients Enrolled
2 Trials studying Thymic Epithelial Tumors
2,038 Patients Enrolled for Thymic Epithelial Tumors
Arun Rajan, M.D.Principal InvestigatorNational Cancer Institute (NCI)
15 Previous Clinical Trials
3,507 Total Patients Enrolled
2 Trials studying Thymic Epithelial Tumors
2,038 Patients Enrolled for Thymic Epithelial Tumors

Eligibility Criteria

Age 18+ · All Participants · 6 Total Inclusion Criteria

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Frequently Asked Questions

When might we see PT-112 on the market?

"PT-112 falls into Phase 2 of clinical trials, meaning that while there is safety data, there is none yet supporting efficacy." - Anonymous Online Contributor

Unverified Answer

Can people with the required qualifications sign up for this clinical trial right now?

"This study, which is currently looking for participants, was first posted on April 6th, 2022. The most recent update to the trial was on October 13th, 2022." - Anonymous Online Contributor

Unverified Answer

How many people can sign up for this research project?

"That is correct. The clinicaltrials.gov website currently has information indicating that this trial is seeking participants. This study was originally posted on April 6th, 2022 and updated on October 13th, 2022. They are looking for 53 people to participate at 1 location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.