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What is Prempro
Conjugated estrogensThe Generic name of this drug
Treatment SummaryConjugated estrogens are a mixture of female sex hormones used to treat certain conditions, such as osteoporosis. The mixture is made up of various estrogens, including estrone sulfate (50%), equilin sulfate (25%), 17-alpha-dehydroequilenin sulfate (15%), equilenin sulfate (3%), and 17-alpha and 17-beta-dihydroequilenin sulfate (5%). It also contains small amounts of other estrogens and non-human molecules (when derived from pregnant mares urine). The product was first approved for marketing
Premarinis the brand name
Prempro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Premarin
Conjugated estrogens
1956
60
Approved as Treatment by the FDA
Conjugated estrogens, also known as Premarin, is approved by the FDA for 10 uses including Vasomotor System and hypoestrogenism .Vasomotor System
Used to treat Moderate to Severe Vasomotor Symptoms in combination with Methyltestosterone
hypoestrogenism
Low Testosterone
Osteoporosis
Used to treat Osteoporosis in combination with Bazedoxifene
Advance Directives
Atrophy of vulva
Premature Menopause
Palliative Treatment
Hot flashes
Used to treat Menopause in combination with Methyltestosterone
female castration
Effectiveness
How Prempro Affects PatientsEstrogens work by attaching to the estrogen receptor and triggering a reaction that leads to changes in genes that affect various body functions. Preclinical studies have shown that conjugated estrogens are just as effective as estrone and have similar effects on the liver as bioidentical estradiol. They also have a selective estrogen receptor modulator profile that can have a positive effect on the bones and heart. When taken, conjugated estrogens help with hormone balance, reduce luteinizing hormone, and lower testosterone levels. They also help with maintaining stability in the body's systems, developing female hormones, and preventing accelerated bone
How Prempro works in the bodyConjugated estrogens work by binding to the body's estrogen receptors. These receptors are found in different amounts and proportions in different tissues, which affects how the conjugated estrogens work. The estrogens cause a change in the body that leads to an increase in the production of DNA, RNA and proteins, which then reduces the release of certain hormones. The exact way this product works is complicated, since each part of it is processed differently by the body.
When to interrupt dosage
The advised dosage of Prempro is contingent upon the diagnosed state, comprising of intense Dyspareunia, female castration and temperate Dyspareunia. The measure of dosage fluctuates, as per the technique of delivery (e.g. Powder, for solution - Intramuscular; Intravenous or Oral) featured in the subsequent table.Condition
Dosage
Administration
Atrophic Vaginitis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
female castration
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Hot flashes
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
hormonal imbalance
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
moderate Dyspareunia
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Kraurosis Vulvae
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Atrophy of vulva
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Metastatic Breast Cancer
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Palliative Treatment
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Vulvitis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Low Testosterone
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Uterine hemorrhage
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Organic Disease
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Osteoporosis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
hypoestrogenism
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
severe Dyspareunia
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Estrogen Replacement Therapy
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Premature Menopause
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Vulvitis
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Vasomotor System
25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral
Warnings
Prempro has fourteen contraindications and should not be utilized in combination with the ailments specified in the following table.Prempro ContraindicationsCondition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
estrogen-dependent neoplasia
Do Not Combine
antithrombin deficiency
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Thromboembolism
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Protein C Deficiency
Do Not Combine
Thrombophilia
Do Not Combine
Breast
Do Not Combine
Liver Dysfunction
Do Not Combine
Protein Deficiency
Do Not Combine
Pulmonary Embolism
Do Not Combine
Common Prempro Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Conjugated estrogens.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Conjugated estrogens.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Conjugated estrogens.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Conjugated estrogens.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Conjugated estrogens.
Prempro Toxicity & Overdose RiskThe lowest toxic dose of estrogens in rats is greater than 5000 mg/kg. No serious overdose symptoms have been reported, but nausea, vomiting, and menstrual bleeding have been observed. Long-term use of estrogens has been linked to an increased risk of certain types of cancer.
Prempro Novel Uses: Which Conditions Have a Clinical Trial Featuring Prempro?
42 active clinical trials are in process to assess the potential of Prempro to mitigate Kraurosis Vulvae, Vasomotor System disorders, as well as severe cases of Dyspareunia.Condition
Clinical Trials
Trial Phases
Atrophic Vaginitis
2 Actively Recruiting
Not Applicable
female castration
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
Vulvitis
0 Actively Recruiting
hormonal imbalance
0 Actively Recruiting
Vulvitis
0 Actively Recruiting
hypoestrogenism
2 Actively Recruiting
Phase 4
Atrophy of vulva
1 Actively Recruiting
Not Applicable
severe Dyspareunia
0 Actively Recruiting
Vasomotor System
0 Actively Recruiting
Premature Menopause
1 Actively Recruiting
Phase 2
Vulvitis
0 Actively Recruiting
moderate Dyspareunia
0 Actively Recruiting
Kraurosis Vulvae
0 Actively Recruiting
Uterine hemorrhage
3 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Organic Disease
0 Actively Recruiting
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Palliative Treatment
0 Actively Recruiting
Prempro Reviews: What are patients saying about Prempro?
5Patient Review
1/31/2018 I've been taking Prempro for six months at the lowest dosage, and it's helped with hot flashes, mood swings, migraines, IBS-D issues, and sleeping. It's truly a wonder drug.
5Patient Review
4/10/2018 I've been using this medication for about a year to help with hot flashes. Not only does it work well, but it's also helped my sex drive (something that often diminishes during menopause). I highly recommend this drug, though be aware that it is on the pricier side.
5Patient Review
7/30/2017 I started Prempro about 8 years ago when I started having serious hot flashes attacks regularly. I appreciate how well this prescription has worked very well for me.
5Patient Review
5/5/2021 This medication has been a game-changer for me. I no longer have to deal with awful hot flashes that would keep me up at night.
5Patient Review
4/17/2022 I started this treatment in my 40s and stopped taking it when I was 84. A year later, I got osteoporosis. The hot flashes and night sweats were terrible. Now I'm back on the medication, but the doctor warned me about blood clots.
4.3Patient Review
4/9/2016 I've been using Prempro for three weeks now, and it's definitely helped reduce the frequency of my hot flashes. I still have them occasionally in the evening, but they're not nearly as bad as they were before. I'm also sleeping better and don't have any daytime hot flashes anymore. The only downside is that I'm eating more because I'm not constantly fighting off chills, but that's something I can work on. Overall, this medication has been a huge help!
4.3Patient Review
10/8/2022 I've only been on this medication for two days, and I can already tell it's working well. My hot flashes have all but gone away and my mood has improved significantly. Menopause started for me in 2014, and it's been a tough journey until now. Thank you!
3Patient Review
10/28/2016 I started this medication a week ago with no issues so far. I'm still waiting for results on my hot flashes; my doctor said it could take up to four weeks. After reading these reviews, I'm a little worried about potential side effects like weight gain.
3Patient Review
9/11/2016 This medication worked great at first--I had no hot flashes and slept much better. However, now that I've been taking it for 3 months I'm more tired and have gained weight. I feel bloated and exhausted all the time. I'm going to stop taking the medication.
2.3Patient Review
5/4/2016 The hot flashes from this drug are honestly not worth the weight gain, increased appetite, and fluid retention. I'm seeing my doctor tomorrow to get a diuretic for the latter issue specifically.
2Patient Review
8/1/2018 I stopped having periods five years ago, but after starting this medication I had discharge and slight spotting. This always required me to use a panty liner, which was annoying. I also felt more mood swings and generally felt crankier or sadder. The only reason I started this medication was for vaginal dryness and painful intercourse, both of which have improved somewhat; however, the drawbacks are not worth it for me.
1Patient Review
9/28/2016 I took this medication for three days but had to stop because the side effects were too much for me. Headaches, nausea, chest pains, and severe mood swings all happened very quickly after starting the treatment.
1Patient Review
3/14/2018 I stopped taking Prempro a few years ago because it kept giving me yeast infections, which my doctor refused to believe were connected to the medication. Once I stopped taking it, the yeast infections went away but I was left in a lot of pain that made sex impossible.
Patient Q&A Section about prempro
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Prempro used for?
"It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. The progestin in this medication helps to reduce the risk of cancer of the uterus, which can be caused by using estrogen."
Answered by AI
What is the difference between estradiol and Prempro?
"The text is discussing the differences between Prempro and Estrace, specifically mentioning that Estrace is easier to use and is available as a cheaper, generic version."
Answered by AI
Is Prempro a hormone replacement?
"Medroxyprogesterone is a type of progestin, a synthetic form of the hormone progesterone.
Prempro is a combination of two medications, conjugated estrogens and medroxyprogesterone. Conjugated estrogens is a mixture of estrogens that replaces the estrogen your body loses during menopause. Medroxyprogesterone is a type of progestin, a synthetic form of the hormone progesterone."
Answered by AI