Non-Invasive Vagus Nerve Stimulation for Stroke Recovery
(NOVIS Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment taVNS for stroke recovery?
Research shows that non-invasive vagus nerve stimulation (taVNS) can improve motor and sensory function in stroke patients, similar to invasive methods but without the need for surgery. Studies indicate that taVNS, when combined with rehabilitation, may enhance recovery by activating similar pathways in the brain as invasive techniques.12345
Is transcutaneous auricular vagus nerve stimulation (taVNS) safe for humans?
How does the treatment taVNS differ from other treatments for stroke recovery?
What is the purpose of this trial?
To evaluate feasibility and effectiveness of non-invasive VNS to enhance stroke recovery
Research Team
Timea Hodics, MD
Principal Investigator
The Methodist Hospital Research Institute
Eligibility Criteria
This trial is for adults over 18 who had a stroke at least 6 months ago and have some movement limitations but can follow simple commands. It's open to all races and genders. People with severe muscle stiffness or those who cannot safely receive non-invasive VNS therapy are excluded.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive non-invasive trans-auricular vagus nerve stimulation (taVNS) during occupational therapy for motor recovery
Follow-up
Participants are monitored for safety and effectiveness after treatment
Open-label extension
Participants in the sham group may receive active taVNS in a cross-over phase to assess sustained clinical improvement
Treatment Details
Interventions
- taVNS
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Methodist Hospital Research Institute
Lead Sponsor