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What is Nolvadex
TamoxifenThe Generic name of this drug
Treatment SummaryTamoxifen is a medication used to treat and prevent breast cancer in certain populations. It is classified as a non-steroidal antiestrogen and works by blocking the effects of estrogen in the body. Tamoxifen is usually used alone or with other treatments and was approved by the FDA in 1977. In some cases, anastrozole may be a preferred treatment for breast cancer due to better survival rates and fewer side effects.
Nolvadexis the brand name
Nolvadex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nolvadex
Tamoxifen
1990
60
Approved as Treatment by the FDA
Tamoxifen, also called Nolvadex, is approved by the FDA for 9 uses which include Malignant Neoplasms and Estrogen Receptors .Malignant Neoplasms
Estrogen Receptors
Breast Cancer
Breast
Breast Surgery
Malignant Neoplasms
Ductal Carcinoma In Situ
Breast Cancer Radiation
High Risk
Effectiveness
How Nolvadex Affects PatientsTamoxifen is a drug that is used to stop the growth and spread of certain types of cancer. It is active in the body for up to 2 weeks and must be taken at a specific dose in order to be effective. If too much is taken, it can cause difficulty breathing or seizures. Additionally, taking Tamoxifen is linked to an increased chance of developing uterine cancer.
How Nolvadex works in the bodyTamoxifen blocks estrogen from binding to its receptor in breast cancer cells. This decreases the number of factors that stimulate tumor growth and increase the amount of a protein that locks up excess estrogen. Tamoxifen also causes cancer cells to die by blocking an enzyme related to DNA synthesis and increasing levels of calcium or tumor growth factor.
When to interrupt dosage
The suggested dosage of Nolvadex is contingent upon the determined condition, such as Ovulation induction therapy, Malignant Neoplasms and McCune Albright Syndrome. The amount of dosage fluctuates according to the administration method outlined in the table below.Condition
Dosage
Administration
Gynecomastia
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
High Risk
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Ovarian Cancer
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast Cancer Radiation
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast Surgery
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Sexual Precocity
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Malignant Neoplasms
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Ovulation induction therapy
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Ductal Carcinoma In Situ
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast Cancer
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Malignant Neoplasms
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Desmoid Tumors
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Estrogen Receptors
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
McCune Albright Syndrome
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Warnings
Nolvadex ContraindicationsCondition
Risk Level
Notes
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Pulmonary Embolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Tamoxifen may interact with Pulse Frequency
Common Nolvadex Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Tamoxifen.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Tamoxifen.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Tamoxifen.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Tamoxifen.
Anastrozole
Major
The serum concentration of Anastrozole can be decreased when it is combined with Tamoxifen.
Nolvadex Toxicity & Overdose RiskTaking too much tamoxifen can cause difficulty breathing and seizures in animals. In people with advanced cancer, it can cause trembling, very sensitive reflexes, difficulty walking, and dizziness. There is no specific treatment for an overdose, so supportive care should be given.
Nolvadex Novel Uses: Which Conditions Have a Clinical Trial Featuring Nolvadex?
Currently, 930 active trials are investigating the potential of Nolvadex to manage Breast Cancer Radiation, Gynecomastia and Malignant Neoplasms.Condition
Clinical Trials
Trial Phases
Breast Cancer Radiation
1 Actively Recruiting
Phase 2
Breast Cancer
714 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Ductal Carcinoma In Situ
1 Actively Recruiting
Phase 2
Sexual Precocity
2 Actively Recruiting
Phase 3
Ovulation induction therapy
0 Actively Recruiting
Estrogen Receptors
0 Actively Recruiting
High Risk
1 Actively Recruiting
Phase 1
Gynecomastia
0 Actively Recruiting
Ovarian Cancer
225 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1
Malignant Neoplasms
22 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 1
Malignant Neoplasms
0 Actively Recruiting
Desmoid Tumors
3 Actively Recruiting
Phase 1, Phase 2, Phase 3
McCune Albright Syndrome
0 Actively Recruiting
Breast Surgery
1 Actively Recruiting
Phase 1, Phase 2
Breast
0 Actively Recruiting
Nolvadex Reviews: What are patients saying about Nolvadex?
5Patient Review
11/6/20094.7Patient Review
5/21/2013 I was diagnosed with breast cancer at 40 and, after a lumpectomy and radiation, started taking Tamoxifen. I've been on it for 9 months now with zero adverse side effects. It doesn't bother my stomach whether I take it with food or not, which is great. Overall, anything that may help me beat this cancer and see my kids grow up is more than okay by me--especially if it comes without any negative drawbacks like other treatments!
4.7Patient Review
7/6/2010 The hot flashes I've been experiencing are a fair trade-off to be cancer free.
3.7Patient Review
11/30/2011 Nolvadex has been helping me for the past year, but I've started to experience some really severe side effects. Things like dry mouth, hot flashes, lower back pain and joint pains, forgetfulness, and dizziness. Do you know of any other medications that might be helpful alternatives?
2.3Patient Review
1/1/2013 I took Tamoxofen for a little more than a year after having a lumpectomy, chemotherapy and radiation. The hot flashes were pretty miserable, but the bone and joint pain along with memory loss and extreme fatigue made me talk to my MD about quality of life issues. The side effects of the drugs made me decide to quit taking it.
Patient Q&A Section about nolvadex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why would a man take Nolvadex?
"Tamoxifen, brand name Nolvadex, is a hormonal therapy used to treat men diagnosed with breast cancer."
Answered by AI
What is Nolvadex used for?
"Nolvadex is an antiestrogen used to treat breast cancer. It is used to treat metastatic breast cancer, breast cancer after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients."
Answered by AI
Is Nolvadex A estrogen blocker?
"Tamoxifen is a drug that is used to treat breast cancer. It is a selective estrogen receptor modulator (SERM) and is used to treat all stages of hormone receptor-positive breast cancer in women and men."
Answered by AI
What does Nolvadex do for PCT?
"Nolvadex is the best drug for reducing estrogen levels, which in turn increases testosterone levels. Phosphatidylserine and acetyl-l-carnitine are two supplements that can be used to lower cortisol levels."
Answered by AI