Nolvadex

Sexual Precocity, Gynecomastia, Ovulation induction therapy + 12 more
Treatment
12 FDA approvals
20 Active Studies for Nolvadex

What is Nolvadex

TamoxifenThe Generic name of this drug
Treatment SummaryTamoxifen is a medication used to treat and prevent breast cancer in certain populations. It is classified as a non-steroidal antiestrogen and works by blocking the effects of estrogen in the body. Tamoxifen is usually used alone or with other treatments and was approved by the FDA in 1977. In some cases, anastrozole may be a preferred treatment for breast cancer due to better survival rates and fewer side effects.
Nolvadexis the brand name
image of different drug pills on a surface
Nolvadex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nolvadex
Tamoxifen
1990
60

Approved as Treatment by the FDA

Tamoxifen, also called Nolvadex, is approved by the FDA for 12 uses which include Malignant Neoplasms and Estrogen Receptors .
Malignant Neoplasms
Estrogen Receptors
Breast Cancer
Invasive Breast Cancer
Ductal Carcinoma In Situ
Malignant Neoplasms
Breast Cancer
Breast
Breast Surgery
Carcinoma, Intraductal, Noninfiltrating
Breast Cancer Radiation
High Risk

Effectiveness

How Nolvadex Affects PatientsTamoxifen is a drug that is used to stop the growth and spread of certain types of cancer. It is active in the body for up to 2 weeks and must be taken at a specific dose in order to be effective. If too much is taken, it can cause difficulty breathing or seizures. Additionally, taking Tamoxifen is linked to an increased chance of developing uterine cancer.
How Nolvadex works in the bodyTamoxifen blocks estrogen from binding to its receptor in breast cancer cells. This decreases the number of factors that stimulate tumor growth and increase the amount of a protein that locks up excess estrogen. Tamoxifen also causes cancer cells to die by blocking an enzyme related to DNA synthesis and increasing levels of calcium or tumor growth factor.

When to interrupt dosage

The suggested dosage of Nolvadex is contingent upon the determined condition, such as Ovulation induction therapy, Malignant Neoplasms and McCune Albright Syndrome. The amount of dosage fluctuates according to the administration method outlined in the table below.
Condition
Dosage
Administration
Ovulation induction therapy
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast Surgery
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
High Risk
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Fibromatosis, Aggressive
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Estrogen Receptors
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast Cancer Radiation
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Sexual Precocity
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Breast Cancer
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Carcinoma, Intraductal, Noninfiltrating
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Gynecomastia
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Ovarian Cancer
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Fibrous Dysplasia, Polyostotic
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Malignant Neoplasms
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit
Malignant Neoplasms
, 10.0 mg, 10.0 mg/mL, 20.0 mg, 2.0 mg/mL, 1.0 mg/mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Liquid, Liquid - Oral, Tablet, Tablet - Oral, Kit

Warnings

Nolvadex Contraindications
Condition
Risk Level
Notes
Venous Thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Pulmonary Embolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Tamoxifen may interact with Pulse Frequency
There are 20 known major drug interactions with Nolvadex.
Common Nolvadex Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Tamoxifen.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Tamoxifen.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Tamoxifen.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Tamoxifen.
Anastrozole
Major
The serum concentration of Anastrozole can be decreased when it is combined with Tamoxifen.
Nolvadex Toxicity & Overdose RiskTaking too much tamoxifen can cause difficulty breathing and seizures in animals. In people with advanced cancer, it can cause trembling, very sensitive reflexes, difficulty walking, and dizziness. There is no specific treatment for an overdose, so supportive care should be given.
image of a doctor in a lab doing drug, clinical research

Nolvadex Novel Uses: Which Conditions Have a Clinical Trial Featuring Nolvadex?

Currently, 930 active trials are investigating the potential of Nolvadex to manage Breast Cancer Radiation, Gynecomastia and Malignant Neoplasms.
Condition
Clinical Trials
Trial Phases
Breast Cancer Radiation
1 Actively Recruiting
Phase 2
Malignant Neoplasms
0 Actively Recruiting
Fibrous Dysplasia, Polyostotic
0 Actively Recruiting
Breast Cancer
26 Actively Recruiting
Phase 2, Phase 1, Not Applicable
Ovulation induction therapy
0 Actively Recruiting
Breast Surgery
0 Actively Recruiting
Estrogen Receptors
0 Actively Recruiting
Malignant Neoplasms
4 Actively Recruiting
Phase 2, Not Applicable
Breast
0 Actively Recruiting
Carcinoma, Intraductal, Noninfiltrating
0 Actively Recruiting
Sexual Precocity
0 Actively Recruiting
Gynecomastia
0 Actively Recruiting
Fibromatosis, Aggressive
2 Actively Recruiting
Phase 2, Phase 3
Ovarian Cancer
17 Actively Recruiting
Phase 1, Phase 2, Not Applicable
High Risk
1 Actively Recruiting
Phase 1

Nolvadex Reviews: What are patients saying about Nolvadex?

5Patient Review
11/6/2009
Nolvadex for Breast Cancer
4.7Patient Review
5/21/2013
Nolvadex for Breast Cancer
I was diagnosed with breast cancer at 40 and, after a lumpectomy and radiation, started taking Tamoxifen. I've been on it for 9 months now with zero adverse side effects. It doesn't bother my stomach whether I take it with food or not, which is great. Overall, anything that may help me beat this cancer and see my kids grow up is more than okay by me--especially if it comes without any negative drawbacks like other treatments!
4.7Patient Review
7/6/2010
Nolvadex for Breast Cancer
The hot flashes I've been experiencing are a fair trade-off to be cancer free.
3.7Patient Review
11/30/2011
Nolvadex for Breast Cancer
Nolvadex has been helping me for the past year, but I've started to experience some really severe side effects. Things like dry mouth, hot flashes, lower back pain and joint pains, forgetfulness, and dizziness. Do you know of any other medications that might be helpful alternatives?
2.3Patient Review
1/1/2013
Nolvadex for Breast Cancer
I took Tamoxofen for a little more than a year after having a lumpectomy, chemotherapy and radiation. The hot flashes were pretty miserable, but the bone and joint pain along with memory loss and extreme fatigue made me talk to my MD about quality of life issues. The side effects of the drugs made me decide to quit taking it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nolvadex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why would a man take Nolvadex?

"Tamoxifen, brand name Nolvadex, is a hormonal therapy used to treat men diagnosed with breast cancer."

Answered by AI

What is Nolvadex used for?

"Nolvadex is an antiestrogen used to treat breast cancer. It is used to treat metastatic breast cancer, breast cancer after surgery and radiation therapy, and to reduce the chances of breast cancer in high-risk patients."

Answered by AI

Is Nolvadex A estrogen blocker?

"Tamoxifen is a drug that is used to treat breast cancer. It is a selective estrogen receptor modulator (SERM) and is used to treat all stages of hormone receptor-positive breast cancer in women and men."

Answered by AI

What does Nolvadex do for PCT?

"Nolvadex is the best drug for reducing estrogen levels, which in turn increases testosterone levels. Phosphatidylserine and acetyl-l-carnitine are two supplements that can be used to lower cortisol levels."

Answered by AI

Clinical Trials for Nolvadex

Have you considered Nolvadex clinical trials? We made a collection of clinical trials featuring Nolvadex, we think they might fit your search criteria.
Have you considered Nolvadex clinical trials? We made a collection of clinical trials featuring Nolvadex, we think they might fit your search criteria.
Have you considered Nolvadex clinical trials? We made a collection of clinical trials featuring Nolvadex, we think they might fit your search criteria.
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